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Learning from the past to prepare for the future

Douglas Johnson and Megan Anne Rees
Med J Aust 2023; 218 (1): . || doi: 10.5694/mja2.51800
Published online: 16 January 2023

Lessons from the COVID‐19 experience can minimise the morbidity, mortality and social disruption of future pandemics

Our society and health care systems have experienced significant challenges and undergone major changes as a consequence of the coronavirus disease 2019 (COVID‐19) pandemic: from the dramatic early days, with high rates of morbidity and mortality overseas,1,2 and the long, difficult lockdowns in several Australian states to incredible advances in medical knowledge in terms of both vaccination and treatment.

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  • 1 The University of Melbourne, Melbourne, VIC
  • 2 The Royal Melbourne Hospital, Melbourne, VIC


Correspondence: douglas.f.johnson@mh.org.au

Competing interests:

No relevant disclosures.

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Welcoming the new MJA Editor‐in‐Chief, and the top ten original research articles in the MJA in 2022

Nicholas J Talley
Med J Aust 2023; 218 (1): . || doi: 10.5694/mja2.51801
Published online: 16 January 2023

It has been a privilege to lead the Journal through challenging times, but it is time to pass the baton

From 23 January 2023, I hand over responsibility for the MJA to the new Editor‐in‐Chief, Professor Virginia (Ginny) Barbour. Professor Barbour is eminently qualified to lead the MJA, having been a Senior Editor at The Lancet and one of the founding editors and the first Chief Editor of PLOS Medicine. She completed her undergraduate immunology and medical degrees at Cambridge University, trained in haematology in the United Kingdom (including at University College London and the Royal Free Hospital), and was awarded her DPhil degree by Oxford University for her investigation of human α‐globin gene regulation. Open access for all medical journals is the future, and Professor Barbour is an internationally recognised expert in innovative scholarly communication, open access, and research integrity. In 2021, she was an expert advisor with the Australian delegation to the intergovernmental meeting of experts on the UNESCO Open Science Recommendation, and she has been involved in many international initiatives, including as vice‐chair of the Declaration on Research Assessment (DORA) steering committee and as a Plan S ambassador. Professor Barbour is based at the Queensland University of Technology, where she is co‐lead of the Office for Scholarly Communication and director of Open Access Australasia; she is also a member of the NHMRC Research Quality Steering Committee, and during the COVID‐19 pandemic was an editorial advisor to the medRxiv preprint server. I congratulate Professor Barbour on her appointment and wish her and the entire MJA team every success in the years to come. I know the Journal will be in very good hands!

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  • Editor‐in‐Chief, the Medical Journal of Australia


Correspondence: ntalley@mja.com.au


Competing interests:

A complete list of disclosures is available at https://www.mja.com.au/journal/staff/editor‐chief‐professor‐nick‐talley.

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The Paediatric Aussie Chocolate Poo Scale

Guy D Eslick and Eloise G Eslick
Med J Aust 2022; 217 (11): . || doi: 10.5694/mja2.51779
Published online: 12 December 2022

The Bristol Stool Scale (BSS) was developed 30 years ago, with the aim of determining the range of bowel habits including stool types in the adult population.1 We conducted a PubMed search (All Fields), which identified more than 600 published papers associated with the BSS. The BSS is currently the gold standard to classify stool consistency in adults. In its present form, it has been useful in assessing intestinal transit time;2 the longer the time, the lower the stool number (eg, type 1 has the slowest transit time [constipation]; type 7 has the fastest transit time [diarrhoea]) (Box 1). The form of the stool strongly influences the act of defecation. The need to strain increases as the type number goes down, and the feeling of urgency increases as the type number rises.1 Feelings of incomplete evacuation occur quite often in normal individuals if their stool is at either end of the scale, but rarely if the stool is type 3 or 4.

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  • 1 Centre for Research Excellence in Digestive Health, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW
  • 2 Clued (Clinical Links using Evidence‐based Data), Sydney, NSW


Correspondence: guy.eslick@sydney.edu.au

Competing interests:

No relevant disclosures.

  • 1. Heaton KW, Radvan J, Cripps H, et al. Defecation frequency and timing, and stool form in the general population: a prospective study. Gut 1992; 33: 818‐824.
  • 2. Lewis SJ, Heaton KW. Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol 1997; 32: 920‐924.
  • 3. Jadrešin O, Hojsak I, Mišak Z, et al. Lactobacillus reuteri DSM 17938 in the treatment of functional abdominal pain in children: RCT study. J Pediatr Gastroenterol Nutr 2017; 64: 925‐929.
  • 4. Bekkali N, Hamers SL, Reitsma JB, et al. Infant stool form scale: development and results. J Pediatr 2009; 154: 521‐526.
  • 5. Velasco‐Benitez CA, Llanos‐Chea A, Saps M. Utility of the Brussels Infant and Toddler Stool Scale (BITSS) and Bristol Stool Scale in non‐toilet‐trained children: a large comparative study. Neurogastroenterol Motil 2021; 33: e14015.

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Clinical staging of clinicians

Gordon B Parker
Med J Aust 2022; 217 (11): . || doi: 10.5694/mja2.51780
Published online: 12 December 2022

Medical practice weights clinical staging models, so why not a staging model for medical practitioners themselves?

Clinical staging models are relevant to managing many medical conditions and have the potential to determine prognosis and phase‐specific interventions. Reflecting this age of personalised medicine, a staging model for personalising clinicians (henceforth, personalised to “you”) is now offered.

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  • University of New South Wales, Sydney, NSW


Correspondence: g.parker@unsw.edu.au


Open access

Open access publishing facilitated by University of New South Wales, as part of the Wiley – University of New South Wales agreement via the Council of Australian University Librarians.


Competing interests:

No relevant disclosures.

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From meals, movies and microbes to a new chocolate yuk scale, mortality among wizards, and medical career staging: season's greetings!

Nicholas J Talley
Med J Aust 2022; 217 (11): . || doi: 10.5694/mja2.51783
Published online: 12 December 2022

Time to celebrate another successful year in difficult times, but we are mindful of the challenges that remain

Welcome to the final MJA issue of 2022! As most Australians take well earned Christmas–New Year breaks, many health professionals across Australia continue to serve their communities, staff our hospitals and clinics, and provide outstanding health care 24 hours a day. We at the MJA thank everyone working in health and medicine for all you do every day, during the holiday season and throughout the year, and hope that you too will find time for a break.

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  • Editor‐in‐Chief, the Medical Journal of Australia


Correspondence: ntalley@mja.com.au

Acknowledgements: 

I thank the tireless efforts of the editorial team throughout 2022, without which the quality and timely publication of our Journal would be impossible: deputy editors Alisha Dorrigan, Francis Geronimo, Robyn Godding, Tania Janusic, Wendy Morgan, Aajuli Shukla, Elizabeth Zuccala, and Maria Inacio; our scientific and structural editors, Paul Foley, Graeme Prince, and Laura Teruel; our consultant biostatistician, Elmer Villanueva; our news and online editor, Cate Swannell; our graphic designer, Leilani Widya; our head of publishing content, Ben Dawe; and our senior publishing coordinator, Kerrie Harding.

Competing interests:

Guy Eslick, the winner of the Christmas competition, is employed part time by the University of Newcastle, and works with the author. A complete list of disclosures is available at https://www.mja.com.au/journal/staff/editor‐chief‐professor‐nick‐talley

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Reducing the burden of group A streptococcal disease in the Northern Territory: the role of chemoprophylaxis for those at greatest risk

Katherine Gibney and Andrew Steer
Med J Aust 2022; 217 (10): . || doi: 10.5694/mja2.51766
Published online: 21 November 2022

The unacceptably high prevalence among Indigenous people and people who need dialysis warrants a clinical trial of prophylactic antibiotics

Relatively little is known about the epidemiology of invasive group A streptococcal (iGAS) disease in Australia. In this issue of the MJA, Birrell and colleagues report that the iGAS disease burden in the Northern Territory continues to fall largely on Indigenous Australians and people undergoing haemodialysis.1 This raises the question of whether antibiotic prophylaxis should be provided to those at greatest risk. Their report is timely, as national public health guidelines are being developed following the listing of iGAS disease as nationally notifiable in July 2021.2


  • 1 Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC
  • 2 Murdoch Children's Research Institute, Melbourne, VIC
  • 3 Royal Children's Hospital Melbourne, Melbourne, VIC



Acknowledgements: 

Katherine Gibney receives salary support from a Medical Research Future Fund (MRFF) fellowship awarded in 2020.

Competing interests:

No relevant disclosures.

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Where should we offer mass drug administration for trachoma?

Jaki Adams, Sung Hye Kim and Anthony W Solomon
Med J Aust 2022; 217 (10): . || doi: 10.5694/mja2.51752
Published online: 21 November 2022

Elimination programs should be guided by the prevalence of markers of infection, not of disease

Trachomatous trichiasis can be devastating: it deforms the eyelid, scars the cornea, and blinds the eye.1 It disables the individual and impoverishes their family; quality of life is severely impaired.2 As restoring sight to a dry eye with a vascularised cornea using keratoplasty is difficult, these effects are generally irreversible. Most people blinded by trachomatous trichiasis live in poor, remote communities without the visual rehabilitation and support services available in major cities.

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  • 1 The Fred Hollows Foundation, Darwin, NT
  • 2 World Health Organization Regional Office for the Western Pacific, Manila, Philippines
  • 3 Hanyang University, Seoul, Republic of Korea
  • 4 World Health Organization, Geneva, Switzerland


Correspondence: solomona@who.int

Competing interests:

Sung Hye Kim and Anthony W Solomon are staff members of the World Health Organization. The authors alone are responsible for the views expressed in this article and they do not necessarily represent the views, decisions, or policies of the institutions with which they are affiliated.

  • 1. Palmer SL, Winskell K, Patterson AE, et al. “A living death”: a qualitative assessment of quality of life among women with trichiasis in rural Niger. Int Health 2014; 6: 291‐297.
  • 2. Habtamu E, Wondie T, Aweke S, et al. The impact of trachomatous trichiasis on quality of life: a case control study. PLoS Negl Trop Dis 2015; 9: e0004254.
  • 3. Solomon AW, Burton MJ, Gower EW, et al. Trachoma. Nat Rev Dis Primers 2022; 8: 32.
  • 4. Gambhir M, Basáñez MG, Burton MJ, et al. The development of an age‐structured model for trachoma transmission dynamics, pathogenesis and control. PLoS Negl Trop Dis 2009; 3: e462.
  • 5. Solomon AW, Holland MJ, Burton MJ, et al. Strategies for control of trachoma: observational study with quantitative PCR. Lancet 2003; 362: 198‐204.
  • 6. Solomon AW, Peeling RW, Foster A, Mabey DC. Diagnosis and assessment of trachoma. Clin Microbiol Rev 2004; 17: 982‐1011.
  • 7. World Health Organization. WHO Alliance for the Global Elimination of Trachoma: progress report on elimination of trachoma, 2021. Wkly Epidemiol Rec 2022; 97: 353‐364. https://www.who.int/publications/i/item/who‐wer9731‐353‐364 (viewed Sept 2022).
  • 8. Kirby Institute. Australian trachoma surveillance report 2019. Sydney: UNSW, 2020. https://kirby.unsw.edu.au/report/australian‐trachoma‐surveillance‐report‐2019 (viewed Sept 2022).
  • 9. Ramadhani AM, Derrick T, Macleod D, et al. The relationship between active trachoma and ocular Chlamydia trachomatis infection before and after mass antibiotic treatment. PLoS Negl Trop Dis 2016; 10: e0005080.
  • 10. World Health Organization Regional Office for the Western Pacific. Expert consultation on the elimination of trachoma in the Pacific: Melbourne, Australia, 17–19 January 2018 [meeting report]. https://apps.who.int/iris/handle/10665/325940 (viewed Sept 2022).
  • 11. O'Brien KS, Emerson P, Hooper PJ, et al. Antimicrobial resistance following mass azithromycin distribution for trachoma: a systematic review. Lancet Infect Dis 2019; 19: e14‐e25.
  • 12. Lynch K, Morotti W, Brian G, et al. Clinical signs of trachoma and laboratory evidence of ocular Chlamydia trachomatis infection in a remote Queensland community: a serial cross‐sectional study. Med J Aust 2022; 217: 538‐543.
  • 13. World Health Organization. Validation of elimination of trachoma as a public health problem (WHO/HTM/NTD/2016.8). Geneva: World Health Organization, 2016. https://apps.who.int/iris/handle/10665/208901 (viewed Sept 2022).
  • 14. World Health Organization. Vanuatu leads the way for Pacific elimination of trachoma: the world's biggest infectious cause of blindness. Manila: World Health Organization, 2022. https://www.who.int/westernpacific/about/how‐we‐work/pacific‐support/news/detail/12‐08‐2022‐vanuatu‐leads‐the‐way‐for‐pacific‐elimination‐of‐trachoma‐‐‐the‐world‐s‐biggest‐infectious‐cause‐of‐blindness (viewed Aug 2022).
  • 15. Butcher R, Handley B, Garae M, et al. Ocular Chlamydia trachomatis infection, anti‐Pgp3 antibodies and conjunctival scarring in Vanuatu and Tarawa, Kiribati before antibiotic treatment for trachoma. J Infect 2020; 80: 454‐461.
  • 16. Butcher R, Tagabasoe J, Manemaka J, et al. Conjunctival scarring, corneal pannus and Herbert's pits in adolescent children in trachoma‐endemic populations of the Solomon Islands and Vanuatu. Clin Infect Dis 2021; 73: e2773–e2780.

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The long term implications of fertility therapy for the health of women

Robert J Norman
Med J Aust 2022; 217 (10): . || doi: 10.5694/mja2.51760
Published online: 21 November 2022

Cardiovascular disease mortality is not increased in women undergoing IVF, but vigilant surveillance is nonetheless required

Since the first birth facilitated by in vitro fertilisation (IVF) in 1978, the use of IVF has spread across the world and more than eight million babies have been born.1 The use of medically assisted reproduction, including IVF, currently accounts for about 7% of all births in Australia, and the annual number of births involving assisted reproductive technology has increased by 55% over the past ten years.2 IVF is a recognised medical technology with a reasonable success rate in younger women, partially funded by Medicare, widely available across Australia, and well accepted by the Australian community.


  • The Robinson Research Institute, the University of Adelaide, Adelaide, SA



Competing interests:

No relevant disclosures.

  • 1. European Society of Human Reproduction and Embryology. Eight million IVF babies since the birth of the world’s first in 1978 [media release]. 4 July 2018. https://www.focusonreproduction.eu/article/ESHRE‐News‐GlobalIVF18 (viewed Oct 2022).
  • 2. Choi SKY, Venetis C, Ledger W, et al. Population‐wide contribution of medically assisted reproductive technologies to overall births in Australia: temporal trends and parental characteristics. Hum Reprod 2022; 37: 1047‐1058.
  • 3. Venn A, Hemminki E, Watson L, et al. Mortality in a cohort of IVF patients. Hum Reprod 2001; 16: 2691‐2696.
  • 4. Venn A, Watson L, Lumley J, et al. Breast and ovarian cancer incidence after infertility and in vitro fertilisation. Lancet 1995; 346: 995‐1000.
  • 5. Yiallourou S, Magliano D, Haregu TN, et al. Long term all‐cause and cardiovascular disease mortality among women who undergo fertility treatment. Med J Aust 2022; 217: 532‐537.
  • 6. Sergentanis TN, Diamantaras AA, Perlepe C, et al. IVF and breast cancer: a systematic review and meta‐analysis. Hum Reprod Update 2014; 20: 106‐123.
  • 7. Spaan M, van den Belt‐Dusebout AW, Lambalk CB, et al. Long‐term risk of ovarian cancer and borderline tumors after assisted reproductive technology. J Natl Cancer Inst 2021; 113: 699‐709.
  • 8. Joham AE, Norman RJ, Stener‐Victorin E, et al. Polycystic ovary syndrome. Lancet Diabetes Endocrinol 2022; 10: 668‐680.
  • 9. Moran LJ, Norman RJ, Teede HJ. Metabolic risk in PCOS: phenotype and adiposity impact. Trends Endocrinol Metab 2015; 26: 136‐143.
  • 10. Wang R, Li W, Bordewijk EM, et al. Reproductive Medicine Network; International Ovulation Induction IPDMA Collaboration. First‐line ovulation induction for polycystic ovary syndrome: an individual participant data meta‐analysis. Hum Reprod Update 2019; 25: 717‐732.
  • 11. Gomes JMD, VanHise K, Stachenfeld N, et al. Subclinical cardiovascular disease and polycystic ovary syndrome. Fert Steril 2022; 117: 912‐923.
  • 12. Saito K, Kuwahara A, Ishikawa T, et al. Endometrial preparation methods for frozen‐thawed embryo transfer are associated with altered risks of hypertensive disorders of pregnancy, placenta accrete and gestational diabetes. Hum Reprod 2019; 34: 1567‐1575.
  • 13. Luke B, Brown MB, Eisenberg M, et al. In vitro fertilization and risk for hypertensive disorders of pregnancy: associations with treatment parameters. Am J Obstet Gynecol 2020; 222: 350.e1‐350. e13.

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Reducing the burden of anaemia for people undergoing major surgery

Philip Crispin
Med J Aust 2022; 217 (9): . || doi: 10.5694/mja2.51748
Published online: 7 November 2022

Pathways and a culture that view blood as disposable must yield to approaches that value patients’ own blood

The often predictable haemostatic challenge of surgery includes the possibility of anaemia increasing procedure‐induced stress and consequently the burden on the patient during the operation and their recuperation. Peri‐operative anaemia has often been managed by transfusion. Blood was regarded as disposable, and the ready supply of donor blood has enabled higher risk invasive procedures in the knowledge that blood can be replaced even in the event of excessive loss. Despite considerable advances in the safety of transfusion, blood remains a biological product with residual risks, including infection and immunological effects. Further, each unnecessarily transfused unit of blood increases the burden on donations.


  • 1 Canberra Hospital, Canberra, ACT
  • 2 Australian National University, Canberra, ACT


Correspondence: philip.crispin@act.gov.au

Competing interests:

I have received funding for my institution from the Australian Commission for Safety and Quality in Healthcare for the National Patient Blood Management Collaborative.

  • 1. Spence RK, Erhard J. History of patient blood management. Best Pract Res Clin Anaesthesiol 2013; 27: 11‐15.
  • 2. Australian National Blood Authority. Patient blood management guidelines, module 2: perioperative. 2012. https://www.blood.gov.au/pbm‐module‐2 (viewed Sept 2022).
  • 3. Muñoz M, Acheson AG, Auerbach M, et al. International consensus statement on the peri‐operative management of anaemia and iron deficiency. Anaesthesia 2017; 72: 233‐247.
  • 4. POSTVenTT Study Collaborative. The management of peri‐operative anaemia in patients undergoing major abdominal surgery in Australia and New Zealand: a prospective cohort study. Med J Aust 2022; 217: 487‐493.
  • 5. Anker SD, Comin Colet J, Filippatos G, et al; FAIR‐HF Trial Investigators. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med 2009; 361: 2436‐2448.
  • 6. Richards T, Baikady RR, Clevenger B, et al. Preoperative intravenous iron to treat anaemia before major abdominal surgery (PREVENTT): a randomised, double‐blind, controlled trial. Lancet 2020; 396: 1353‐1361.
  • 7. Australian Commission on Safety and Quality in Health Care. Resources for improved patient blood management. Nov 2017. https://www.safetyandquality.gov.au/sites/default/files/migrated/National‐Patient‐Blood‐Management‐Collaborative‐NPBMC‐Resource‐Booklet‐November‐2017.pdf (viewed Sept 2022).
  • 8. Cancer Council Victoria; Department of Heath Victoria. Optimal care pathway for people with colorectal cancer. Second edition. https://www.cancer.org.au/assets/pdf/colorectal‐cancer‐optimal‐cancer‐care‐pathway (viewed Sept 2022).

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The Future Healthy Countdown 2030: holding Australia to account for the health and wellbeing of future generations

Sandro Demaio, Sharon R Goldfeld, Anne Hollonds, George C Patton, Fiona J Stanley, Rosemary Calder, Kate Lycett and Zuleika Arashiro
Med J Aust 2022; 217 (9): . || doi: 10.5694/mja2.51746
Published online: 7 November 2022

It is time to reimagine wellbeing and place the future of our children and young people at the centre of public action

As we approach World Children’s Day and the 2022 United Nations Climate Change Conference (COP27), we are once again reminded of how lack of leadership and coordinated action is threatening the future of humankind and, particularly, that of our children, young people and generations to come.1 Although climate change had already affected how younger generations and their parents imagine a healthy future, the onset of the global coronavirus disease 2019 (COVID‐19) pandemic has only served to heighten their concerns.2 Research from around the world indicates that children and young people have been disproportionately burdened by the changes and challenges of the past 3 years. The sudden disruptions and high uncertainty at critical points of their development, along with the mental health and financial impacts on their parents, have placed a heavy toll on their wellbeing.3 However, even before the pandemic, there were growing concerns that, for the first time, the current generation of children would be less healthy than their parents.4

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  • 1 Victorian Health Promotion Foundation, VicHealth, Melbourne, VIC
  • 2 Centre for Community Child Health, Royal Children’s Hospital, Melbourne, VIC
  • 3 Australian Human Rights Commission, Sydney, NSW
  • 4 University of Melbourne, Melbourne, VIC
  • 5 Centre for Adolescent Health, Murdoch Children’s Research Institute, Melbourne, VIC
  • 6 Telethon Kids Institute, Perth, WA
  • 7 University of Western Australia, Perth, WA
  • 8 Mitchell Institute, Victoria University, Melbourne, VIC
  • 9 Centre for Social and Early Emotional Development, Deakin University, Geelong, VIC
  • 10 Murdoch Children’s Research Institute, Melbourne, VIC



Competing interests:

No relevant disclosures.

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