MJA
MJA

Preventing ovarian failure associated with chemotherapy

Wanyuan Cui, Catharyn Stern, Martha Hickey, Fiona Goldblatt, Antoinette Anazodo, William S Stevenson and Kelly-Anne Phillips
Med J Aust 2018; 209 (9): . || doi: 10.5694/mja18.00190
Published online: 5 November 2018

Summary

 

  • Alkylating chemotherapy is often used to treat pre-menopausal women for various malignancies and autoimmune diseases. Chemotherapy-associated ovarian failure is a potential consequence of this treatment which can cause infertility, and increases the risk of other long term adverse health sequelae.
  • Randomised trials, predominantly of women undergoing alkylating chemotherapy for breast cancer, have shown evidence for the efficacy of gonadotropin-releasing hormone agonists (GnRHa) in preventing chemotherapy-associated ovarian failure.
  • The European St Gallen and United States National Comprehensive Cancer Network guidelines recommend the use of concurrent GnRHa to reduce the risk of ovarian failure for pre-menopausal women undergoing chemotherapy for breast cancer.
  • The GnRHa goserelin, a monthly 3.6 mg depot subcutaneous injection, has recently been listed on the Australian Pharmaceutical Benefits Scheme to reduce risk of ovarian failure for pre-menopausal women receiving alkylating therapies for malignancy or autoimmune disease.
  • The first dose of goserelin should ideally be administered at least 1 week before commencement of alkylating treatment and continued 4-weekly during chemotherapy.
  • Concurrent goserelin use should now be considered for all pre-menopausal women due to commence alkylating chemotherapy (except those with incurable cancer), regardless of their childbearing status, in an effort to preserve their ovarian function. For women who have not completed childbearing, consideration of other fertility preservation options, such as cryopreservation of embryos or oocytes, is also important.

 

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Updated clinical practice guidelines on pregnancy care

Caroline SE Homer, Jeremy Oats, Philippa Middleton, Jenny Ramson and Samantha Diplock
Med J Aust 2018; 209 (9): . || doi: 10.5694/mja18.00286
Published online: 5 November 2018

Abstract

Introduction: The clinical practice guidelines on pregnancy care have been developed to provide reliable and standardised guidance for health professionals providing antenatal care in Australia. They were originally released as the Clinical Practice Guidelines: Antenatal Care in two separate editions (modules 1 and 2) in 2012 and 2014. These modules have now been combined and updated to form a single set of consolidated guidelines that were publicly released in February 2018 as the Clinical Practice Guidelines: Pregnancy Care. Eleven topics have been updated and new guidance on substance use in pregnancy has been added.

Main recommendations: The updated guidelines include the following key changes to practice:

  • recommend routine testing for hepatitis C at the first antenatal visit;
  • recommend against routine testing for vitamin D status in the absence of a specific indication;
  • recommend discussing weight change, diet and physical activity with all pregnant women; and
  • recommend offering pregnant women the opportunity to be weighed at every antenatal visit and encouraging women to self-monitor weight gain.

Changes in management as a result of the guidelines: The guidelines will enable pregnant women diagnosed with hepatitis C to be identified and thus avoid invasive procedures that increase the risk of mother-to-baby transmission. Women can be treated postpartum, reducing the risk of liver disease and removing the risk of perinatal infection for subsequent pregnancies. Routine testing of all pregnant women for vitamin D status and subsequent vitamin D supplementation is not supported by evidence and should cease as the benefits and harms of vitamin D supplementation remain unclear. The recommendation for health professionals to provide advice to pregnant women about weight, diet and physical activity, and the opportunity to be weighed will help women to make changes leading to better health outcomes for themselves and their babies.


  • 1 Centre for Midwifery, Child and Family Health, UTS Sydney, Sydney, NSW
  • 2 Burnet Institute, Melbourne, VIC
  • 3 Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC
  • 4 Robinson Research Institute, University of Adelaide, Adelaide, SA
  • 5 Ampersand Health Science Writing, Tanja, NSW
  • 6 Department of Health, Canberra, ACT


Correspondence: caroline.homer@uts.edu.au

Acknowledgements: 

The review of the guidelines was jointly funded by the Australian Government and the states and territories. The review was project managed by the Australian Government Department of Health. The authors acknowledge the engagement and support of the Australian College of Midwives, the Congress of Aboriginal and Torres Strait Islander Nurses and Midwives, the Royal Australian College of General Practitioners and the Royal Australian and New Zealand College of Obstetricians and Gynaecologists. EWG members who have supported the review of the guidelines: Professor Jeremy Oats, University of Melbourne (co-chair); Professor Caroline Homer, University of Technology Sydney and the Australian College of Midwives (co-chair); Associate Professor Philippa Middleton, South Australian Health and Medical Research Institute Adelaide; Dr Martin Byrne, Royal Australian College of General Practitioners; Ann Catchlove, consumer representative; Lisa Clements, migrant and refugee women representative; Dr Anthony Hobbs, Commonwealth Deputy Chief Medical Officer; Tracy Martin, WA Health; Professor Sue McDonald, La Trobe University; Dr Sarah Jane McEwan, Western Australian Country Hedland Service; Professor Michael Permezel, Royal Australian College of Obstetricians and Gynaecologists; Adjunct Professor Debra Thoms, Commonwealth Chief Nursing and Midwifery Officer; Louis Young, Department of Health (Secretariat); Samantha Diplock, Department of Health (Secretariat); Anita Soar, Department of Health (Secretariat); and Jenny Ramson, Ampersand Health Science Writing (technical writer).

Competing interests:

No relevant disclosures.

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Pre-conception care: an important yet underutilised preventive care strategy

Deborah J Bateson and Kirsten I Black
Med J Aust 2018; 209 (9): . || doi: 10.5694/mja18.00769
Published online: 5 November 2018

Parental health prior to conception is increasingly recognised as being important for the health of future generations

Pre-conception care is the provision of health recommendations to women of reproductive age with the goal of improving short and long term health outcomes for both the mothers and their children. It includes an assessment of medical conditions, vaccination status, and lifestyle factors.1 While pre-conception care will benefit any woman contemplating pregnancy, it is particularly important for women with medical conditions such as diabetes and obesity. Nevertheless, it is often underutilised.2 In this article, we describe strategies for overcoming challenges to providing pre-conception care and provide guidance for time-poor clinicians.


  • 1 Family Planning New South Wales, Sydney, NSW
  • 2 University of Sydney, Sydney, NSW
  • 3 Royal Prince Alfred Hospital, Sydney, NSW


Correspondence: deborahb@fpnsw.org.au

Competing interests:

No relevant disclosures.

  • 1. Royal Australian College of General Practitioners. Preventive activities prior to pregnancy. In: Guidelines for preventive activities in general practice. 9th edition. Melbourne: RACGP, 2017. https://www.racgp.org.au/clinical-resources/clinical-guidelines/key-racgp-guidelines/view-all-racgp-guidelines/red-book/preventive-activities-prior-to-pregnancy (viewed Sept 2018).
  • 2. McElduff A, Ross GP, Lagstrom JA, et al. Pregestational diabetes and pregnancy: an Australian experience. Diabetes Care 2005; 28: 1260-1261.
  • 3. Rassi A, Wattimena J, Black K. Pregnancy intention in an urban Australian antenatal population. Aust N Z J Public Health 2013; 37: 568-573.
  • 4. Mazza D, Chapman A, Michie S. Barriers to the implementation of preconception care guidelines as perceived by general practitioners: a qualitative study. BMC Health Serv Res 2013; 13: 36.
  • 5. Bellanca HK, Hunter MS. ONE KEY QUESTION: preventive reproductive health is part of high quality primary care. Contraception 2013; 88: 3-6.
  • 6. Tommy’s. Planning for pregnancy [website]. 2018. https://www.tommys.org/pregnancy-information/planning-pregnancy/planning-for-pregnancy-tool (viewed Sept 2018).
  • 7. De-Regil LM, Peña-Rosas JP, Férnandez-Gaxiola AC, Rayco-Solon P. Effects and safety of periconceptional oral folate supplementation for preventing birth defects. Cochrane Database Syst Rev 2015; (12): CD007950.
  • 8. Harding KB, Peña-Rosas JP, Webster AC, et al. Iodine supplementation for women during the preconception, pregnancy and postpartum period. Cochrane Database Syst Rev 2017; (3): CD011761.
  • 9. Schummers L, Hutcheon JA, Bodnar LM, et al. Risk of adverse pregnancy outcomes by prepregnancy body mass index: a population-based study to inform prepregnancy weight loss counseling. Obstet Gynecol 2015; 125: 133-143.
  • 10. Boggess KA, Edelstein BL. Oral health in women during preconception and pregnancy: implications for birth outcomes and infant oral health. Matern Child Health J 2006; 10: 169-174.
  • 11. Blatt K, Moore E, Chen A, et al. Association of reported trimester-specific smoking cessation with fetal growth restriction. Obstet Gynecol 2015; 125: 1452-1459.
  • 12. Lassi ZS, Imam AM, Dean SV, Bhutta ZA. Preconception care: caffeine, smoking, alcohol, drugs and other environmental chemical/radiation exposure. Reprod Health 2014; 11: S6.
  • 13. Conde-Agudelo A, Rosas-Bermúdez A, Kafury-Goeta AC. Birth spacing and risk of adverse perinatal outcomes: a meta-analysis. JAMA 2006; 295: 1809-1823.
  • 14. Hanley GE, Hutcheon JA, Kinniburgh BA, Lee L. Interpregnancy interval and adverse pregnancy outcomes: an analysis of successive pregnancies. Obstet Gynecol 2017; 129: 408-415.
  • 15. Guerin A, Nisenbaum R, Ray JG. Use of maternal GHb concentration to estimate the risk of congenital anomalies in the offspring of women with prepregnancy diabetes. Diabetes Care 2007; 30: 1920-1925.
  • 16. Lassi ZS, Imam AM, Dean SV, Bhutta ZA. Preconception care: screening and management of chronic disease and promoting psychological health. Reprod Health 2014; 11: S5.
  • 17. Australian Government Department of Health. Immunisation for pregnancy. https://beta.health.gov.au/health-topics/immunisation/immunisation-throughout-life/immunisation-for-pregnancy (viewed Sept 2018).
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  • 19. Oteng-Ntim E, Mononen S, Sawicki O, et al. Interpregnancy weight change and adverse pregnancy outcomes: a systematic review and meta-analysis. BMJ Open 2018; 8: e018778.
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Endemic unprofessional behaviour in health care: the mandate for a change in approach

Johanna Westbrook, Neroli Sunderland, Victoria Atkinson, Catherine Jones and Jeffrey Braithwaite
Med J Aust 2018; 209 (9): . || doi: 10.5694/mja17.01261
Published online: 5 November 2018

Pervasive bullying, discrimination and sexual harassment are increasingly hard to ignore, yet evidence of effective interventions is lacking

Unprofessional behaviour is sufficiently widespread in the Australian health care system that it could be considered endemic. The 2016 survey of the Victorian Public Sector Commission found that 25% of staff in health agencies experienced bullying,1 and in a 2014 survey of the Australian Nursing and Midwifery Federation, 40% of nurses reported bullying or harassment in the previous 12 months.2 In 2015, the Royal Australasian College of Surgeons surveyed 3516 surgical Fellows, trainees and international medical graduates and found that 49% had been subjected to discrimination, bullying, harassment or sexual harassment.3 The Australasian College for Emergency Medicine released in 2017 its survey results: 34% of respondents had experienced bullying, 21.7% discrimination, 16.1% harassment and 6.2% sexual harassment.4 Thus, unsurprisingly, the 2016 Senate inquiry into the medical complaints process concluded that bullying, discrimination and harassment levels remain disconcertingly high despite the apparent “zero tolerance” approach reported by medical administrators and colleges.5


  • 1 Australian Institute of Health Innovation, Macquarie University, Sydney, NSW
  • 2 St Vincent's Health Australia, Melbourne, VIC


Correspondence: johanna.westbrook@mq.edu.au

Acknowledgements: 

The authors are recipients of a National Health and Medical Research Council Partnership Project Grant (1134459) for this work.

Competing interests:

Victoria Atkinson and Catherine Jones are employees of St Vincent’s Health Australia.

  • 1. Victorian Auditor-General. Bullying and harassment in the health sector: Victorian Auditor-General’s report. Melbourne: Victorian Auditor General’s Office; 2016. https://www.audit.vic.gov.au/sites/default/files/20160323-Bullying.pdf (viewed Nov 2017).
  • 2. De Cieri H, Shea T, Sheehan C, et al. Leading indicators of OHS performance in the health services: a report on a survey of Australian Nursing and Midwifery Federation (Victorian Branch) members. Melbourne: Monash University; 2015.
  • 3. Royal Australasian College of Surgeons. Expert Advisory Group advising the Royal Australasian College of Surgeons: discrimination, bullying and sexual harassment prevalence survey. Melbourne: RACS, 2015. https://surgeons.org/media/22045682/PrevalenceSurvey_Summary-of-Facts_FINAL.pdf (viewed Nov 2017).
  • 4. Australasian College for Emergency Medicine. ACEM to tackle bullying and harassment. Melbourne: ACEM; 2017. https://acem.org.au/News/Aug-2017/ACEM-to-tackle-bullying-and-harassment (viewed Nov 2017).
  • 5. Senate Standing Committee on Community Affairs. Medical complaints process in Australia. Canberra: Parliament of Australia; 2016. http://www.aph.gov.au/Parliamentary_Business/Committees/Senate/Community_Affairs/Medical_Complaints (viewed Nov 2017).
  • 6. Hickson BG, Pichert WJ, Webb EL, Gabbe SG. A complementary approach to promoting professionalism: identifying, measuring, and addressing unprofessional behaviors. Acad Med 2007; 82: 1040-1048.
  • 7. Loerbroks A, Weigl M, Li J, et al. Workplace bullying and depressive symptoms: a prospective study among junior physicians in Germany. J Psychosom Res 2015; 78: 168-172.
  • 8. Reknes I, Pallesen S, Magerøy N, et al. Exposure to bullying behaviors as a predictor of mental health problems among Norwegian nurses: results from the prospective SUSSH-survey. Int J Nurs Stud 2014; 51: 479-487.
  • 9. Rosenstein A, O’Daniel M. A survey of the impact of disruptive behaviors and communication defects on patient safety. Jt Comm J Qual Patient Saf 2008; 34: 464-471.
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  • 11. Ortega A, Christensen KB, Hogh A, et al. One-year prospective study on the effect of workplace bullying on long-term sickness absence. J Nurs Manag 2011; 19: 752-759.
  • 12. Nielsen MB, Indregard AM, Øverland S. Workplace bullying and sickness absence: a systematic review and meta-analysis of the research literature. Scand J Work Environ Health 2016; 42: 359-370.
  • 13. Hickson GB, Federspiel CF, Pichert JW, et al. Patient complaints and malpractice risk. JAMA 2002; 287: 2951-2957.
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  • 15. Rawson JV, Thompson N, Sostre G, et al. The cost of disruptive and unprofessional behaviors in health care. Acad Radiol 2013; 20: 1074-1076.
  • 16. Riskin A, Erez A, Foulk TA, et al. The impact of rudeness on medical team performance: a randomized trial. Pediatrics 2015; 136: 487-495.
  • 17. Cooper WO, Guillamondegui O, Hines OJ, et al. Use of unsolicited patient observations to identify surgeons with increased risk for postoperative complications. JAMA Surg 2017; 152: 522-529.
  • 18. Cruess RL, Cruess SR, Steinert Y. Amending Miller’s pyramid to include professional identity formation. Acad Med 2016; 91: 180-185.
  • 19. Rees CE, Monrouxe LV. Who are you and who do you want to be? Key considerations in developing professional identities in medicine. Med J Aust 2018; 209: 202-203. <MJA full text>
  • 20. Foster K, Roberts C. The heroic and the villainous: a qualitative study characterising the role models that shaped senior doctors’ professional identity. BMC Med Educ 2016; 16: 206.
  • 21. Scott KM, Caldwell PH, Barnes EH, Barrett J. “Teaching by humiliation” and mistreatment of medical students in clinical rotations: a pilot study. Med J Aust 2015; 203: 185. <MJA full text>
  • 22. Gillen PA, Sinclair M, Kernohan WG, et al. Interventions for prevention of bullying in the workplace. Cochrane Database Syst Rev 2017; 1: CD009778.
  • 23. Leiter MP, Laschinger HKS, Day A, Oore DG. The impact of civility interventions on employee social behavior, distress, and attitudes. J Appl Psychol 2011; 96: 1258-1274.
  • 24. Osatuke K, Leiter M, Belton L, et al. Civility, Respect and Engagement at the Workplace (CREW): a national organization development program at the Department of Veterans Affairs. Journal of Management Policies and Practices 2013; 1: 25-34.
  • 25. Webb LE, Dmochowski RR, Moore IN, et al. Using coworker observations to promote accountability for disrespectful and unsafe behaviors by physicians and advanced practice professionals. Jt Comm J Qual Patient Saf 2016; 42: 149-164.
  • 26. Medew J. Royal Melbourne Hospital targets bullying with new Cognitive Institute program. The Age (Melbourne) 2016; 28 May. https://www.theage.com.au/national/victoria/royal-melbourne-hospital-targets-bullying-with-new-cognitive-institute-program-20160527-gp5377.html (viewed Apr 2018).
  • 27. Atkinson V, Jones, C. The St Vincent’s Ethos Program is “redefining normal” with a pragmatic approach to addressing unprofessional behaviour [unpublished presentation]. 34th International Society for Quality in Healthcare Conference. London (United Kingdom), 1-4 Oct 2017. https://www.isqua.org/research/resources.html?page=1&search=&types%5B3%5D=3&date_range_start=&date_range_end=&events%5B1%5D=1 (viewed Apr 2018).
  • 28. Montgomery A, Panagopoulou E, Kehoe I, Valkanos E. Connecting organisational culture and quality of care in the hospital: is job burnout the missing link? J Health Organ Manag 2011; 25: 108-123.
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A perfect storm: towards reducing the risk of suicide in the medical profession

Ann I McCormack
Med J Aust 2018; 209 (9): . || doi: 10.5694/mja18.00221
Published online: 5 November 2018

Helping doctors build resilience may be protective against burnout and suicide in times of personal hardship

Having successive generations of doctors in one family — a “medical pedigree” — was once a source of great pride. As the daughter of a doctor and now a mother, I am surprised to find myself hoping my own children do not follow in my footsteps. This is not because of my own career dissatisfaction. In fact, my work is immensely rewarding, but recently, I have been reflecting on the hardships a medical career entails: the gruelling training pathway, the complex medical culture and the constant battle to achieve a work–life balance. I have now witnessed the devastating personal consequences when the rocky road seems impossible to navigate. Over a matter of months, two female junior doctors committed suicide, and more recently, suicide entered my inner circle with the death of one my close male colleagues. Such stories are not unusual in our profession. I do not claim any expertise in this field, but what seems clear to me is that inherent traits in the individuals who choose a career in medicine, and often create excellent doctors, also set them up for high rates of distress. We have a medical workforce that has gone through rapid evolutionary change, and if we combine these factors with exposure to dysfunctional aspects of our medical culture or personal stressors, we have ingredients for a perfect storm.


  • 1 St Vincent's Hospital, Sydney, NSW
  • 2 Garvan Institute of Medical Research, Sydney, NSW


Correspondence: a.mccormack@garvan.org.au

Acknowledgements: 

I thank Yael Barnett for assistance in setting up Vinnies Women in Medicine and reviewing a draft of this manuscript.

Competing interests:

No relevant disclosures.

  • 1. Schernhammer ES, Colditz GA. Suicide rates among physicians: a quantitative and gender assessment (meta-analysis). Am J Psychiatry 2004; 161: 2295-2302.
  • 2. Collier R. Physician suicide too often “brushed under the rug”. CMAJ 2017; 189: E1240-E1241.
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  • 7. Halliday L, Walker A, Vig S, et al. Grit and burnout in UK doctors: a cross-sectional study across specialties and stages of training. Postgrad Med J 2017; 93: 389-394.
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  • 9. Beyondblue. National Mental Health Survey of Doctors and Medical Students, October 2013. beyondblue; 2013. https://www.beyondblue.org.au/docs/default-source/research-project-files/bl1132-report---nmhdmss-full-report_web (viewed Sept 2018).
  • 10. Guille C, Frank E, Zhao Z, et al. Work–family conflict and the sex difference in depression among training physicians. JAMA Intern Med 2017; 177: 1766-1772.
  • 11. Australian Medical Association. National Code of Practice — hours of work, shiftwork and rostering for hospital doctors. Kingston, ACT: AMA; 2016. https://ama.com.au/article/national-code-practice-hours-work-shiftwork-and-rostering-hospital-doctors (viewed Sept 2018).
  • 12. Parr JM, Pinto N, Hanson M, et al. Medical graduates, tertiary hospitals, and burnout: a longitudinal cohort study. Ochsner J 2016; 16: 22-26.
  • 13. Bismark MM, Spittal MJ, Morris JM, Studdert DM. Reporting of health practitioners by their treating practitioner under Australia’s national mandatory reporting law. Med J Aust 2016; 204: 24. <MJA full text>
  • 14. Chand SP, Chibnall JT, Slavin SJ. Cognitive behavioral therapy for maladaptive perfectionism in medical students: a preliminary investigation. Acad Psychiatry 2018; 42: 58-61.
  • 15. Lattie EG, Duffecy JL, Mohr DC, Kashima K. Development and evaluation of an online mental health program for medical students. Acad Psychiatry 2017; 41: 642-645.
  • 16. Shanafelt TD, Noseworthy JH. Executive leadership and physician well-being: nine organizational strategies to promote engagement and reduce burnout. Mayo Clin Proc 2017; 92: 129-146.
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The first published randomised controlled trial of laser treatment for vaginal atrophy raises serious questions

Melissa J Buttini and Christopher Maher
Med J Aust 2018; 209 (9): . || doi: 10.5694/mja18.00187
Published online: 5 November 2018

We still await well conducted RCTs of CO2 laser therapy for vaginal atrophy; in the meantime, topical oestrogen therapy remains the gold standard

Vaginal laser therapy has entered the global marketplace promising women relief from symptoms of genitourinary syndrome of menopause (GSM), formerly known as vulvovaginal atrophy.


  • 1 The Wesley Hospital, Brisbane, QLD
  • 2 University of Queensland, Brisbane, QLD


Correspondence: melissa.buttini0@gmail.com

Competing interests:

No relevant disclosures.

  • 1. American College of Obstetricians and Gynecologists: Fractional laser treatment of vulvovaginal atrophy and US Food and Drug Administration clearance: position statement. Washington, DC: ACOG, approved May 2016, reaffirmed July 2018. https://www.acog.org/Clinical-Guidance-and-Publications/Position-Statements/Fractional-Laser-Treatment-of-Vulvovaginal-Atrophy-and-US-Food-and-Drug-Administration-Clearance (viewed Sept 2018).
  • 2. Therapeutic Goods Administration. Public summary for ARTG entry: 106780 High Tech Laser Australia P/L. https://www.ebs.tga.gov.au/servlet/xmlmillr6?dbid=ebs/PublicHTML/pdfStore.nsf&docid=B5C3E89B35339C9ECA2577DD0001F0EB&agid=(PrintDetailsPublic)&actionid=1 (viewed Feb 2018).
  • 3. US Food and Drug Administration. Guidance for industry: estrogen and estrogen/progestin drug products to treat vasomotor symptoms and vulvar and vaginal atrophy symptoms – recommendations for clinical evaluation. Rockville, MD: FDA, 2003. https://www.fda.gov/downloads/Drugs/DrugSafety/informationbyDrugClass/UCM135338.pdf (viewed Feb 2018).
  • 4. Chollet JA. Efficacy and safety of ultra-low-dose Vagifem (10 mcg). Patient Prefer Adherence 2011; 5: 571-574.
  • 5. Wurz GT, Kao CJ, DeGregorio MW. Safety and efficacy of ospemifene for the treatment of dyspareunia associated with vulvar and vaginal atrophy due to menopause. Clin Interv Aging 2014; 9: 1939-1950.
  • 6. Salvatore S, Nappi RE, Zerbinati N, et al. A 12-week treatment with fractional CO2 laser for vulvovaginal atrophy: a pilot study. Climacteric 2014; 17: 363-369.
  • 7. Salvatore S, Nappi RE, Parma M, et al. Sexual function after fractional microablative CO2 laser in women with vulvovaginal atrophy. Climacteric 2015; 18: 219-225.
  • 8. Salvatore S, Leone Roberti Maggiore U, Athanasiou S, et al. Histological study on the effects of microablative fractional CO2 laser on atrophic vaginal tissue: an ex vivo study. Menopause 2015; 22: 845-849.
  • 9. Athanasiou S, Pitsouni E, Antonopoulou S, et al. The effect of microablative fractional CO2 laser on vaginal flora of postmenopausal women. Climacteric 2016; 19: 512-518.
  • 10. Pitsouni E, Grigoriadis T, Tsiveleka A, et al. Microablative fractional CO2 laser therapy and the genitourinary syndrome of menopause: an observational study. Maturitas 2016; 94: 131-136.
  • 11. Salvatore S, Pitsouni E, Del Deo F, et al. Sexual function in women suffering from genitourinary syndrome of menopause treated with fractionated CO2 laser. Sex Med Rev 2017; 5: 486-494.
  • 12. Athanasiou S, Pitsouni E, Falagas ME, et al. CO2 laser for the genitourinary syndrome of menopause. How many laser sessions? Maturitas 2017; 104: 24-28.
  • 13. Cruz VL, Steiner ML, Pompei LM, et al. Randomized, double-blind, placebo-controlled clinical trial for evaluating the efficacy of fractional CO2 laser compared with topical estriol in the treatment of vaginal atrophy in postmenopausal women. Menopause 2018; 25: 21-28.
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Revised Australian national guidelines for colorectal cancer screening: family history

Mark A Jenkins, Driss Ait Ouakrim, Alex Boussioutas, John L Hopper, Hooi C Ee, Jon D Emery, Finlay A Macrae, Albert Chetcuti, Laura Wuellner and D James B St John
Med J Aust 2018; 209 (10): . || doi: 10.5694/mja18.00142
Published online: 29 October 2018

Abstract

Introduction: Screening is an effective means for colorectal cancer prevention and early detection. Family history is strongly associated with colorectal cancer risk. We describe the rationale, evidence and recommendations for colorectal cancer screening by family history for people without a genetic syndrome, as reported in the 2017 revised Australian guidelines.

Main recommendations: Based on 10-year risks of colorectal cancer, people at near average risk due to no or weak family history (category 1) are recommended screening by immunochemical faecal occult blood test (iFOBT) every 2 years from age 50 to 74 years. Individuals with moderate risk due to their family history (category 2) are recommended biennial iFOBT from age 40 to 49 years, then colonoscopy every 5 years from age 50 to 74 years. People with a high risk due to their family history (category 3) are recommended biennial iFOBT from age 35 to 44 years, then colonoscopy every 5 years from age 45 to 74 years.

Changes in management as a result of the guidelines: By 2019, the National Bowel Cancer Screening Program will offer all Australians free biennial iFOBT screening from age 50 to 74 years, consistent with the recommendations in these guidelines for category 1. Compared with the 2005 guidelines, there are some minor changes in the family history inclusion criteria for categories 1 and 2; the genetic syndromes have been removed from category 3 and, as a consequence, colonoscopy screening is now every 5 years; and for categories 2 and 3, screening begins with iFOBT for people aged 40 and 35 years, respectively, before transitioning to colonoscopy after 10 years.


  • 1 University of Melbourne, Melbourne, VIC
  • 2 Royal Melbourne Hospital, Melbourne, VIC
  • 3 Sir Charles Gardiner Hospital, Perth, WA
  • 4 Cancer Council Australia, Sydney, NSW
  • 5 Agency for Clinical Innovation, Sydney, NSW
  • 6 Cancer Council Victoria, Melbourne, VIC


Correspondence: m.jenkins@unimelb.edu.au

Acknowledgements: 

Mark Jenkins has a Research Fellowship from the NHMRC.

Competing interests:

Albert Chetcuti and Laura Wuellner are employed by Cancer Council Australia to assist in the preparation of these guidelines — Cancer Council Australia received financial support from both Cancer Council Australia and the Australian Government Department of Health. Mark Jenkins, Jon Emery, Finlay Macrae and James St. John received travel support from Cancer Council Australia to attend meetings for development of the guidelines. Mark Jenkins, Jon Emery, Finlay Macrae and James St. John are members of the Clinical Advisory Group of the National Bowel Cancer Screening Program and received travel support and sitting fees.

  • 1. Australian Institute of Health and Welfare 2017. Cancer in Australia 2017 (AIHW Cat. No. CAN 100; Cancer Series No. 101). Canberra: AIHW; 2017. https://www.aihw.gov.au/getmedia/3da1f3c2-30f0-4475-8aed-1f19f8e16d48/20066-cancer-2017.pdf.aspx?inline=true (viewed Aug 2018).
  • 2. Cancer Council Australia; Colorectal Cancer Guidelines Working Party. Clinical practice guidelines for the prevention, early detection and management of colorectal cancer. Sydney: Cancer Council Australia; 2017. https://wiki.cancer.org.au/australiawiki/index.php?oldid=173168 (viewed Jan 2018).
  • 3. Johns LE, Houlston RS. A systematic review and meta-analysis of familial colorectal cancer risk. Am J Gastroenterol 2001; 96: 2992-3003.
  • 4. Lynch HT, Lanspa S, Shaw T, et al. Phenotypic and genotypic heterogeneity of Lynch syndrome: a complex diagnostic challenge. Fam Cancer 2018; 17: 403-414.
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Redefining the physician’s role in the era of online health information

Susan Ieraci
Med J Aust 2018; 209 (8): . || doi: 10.5694/mja18.00652
Published online: 15 October 2018

Clinicians are no longer gatekeepers to privileged information, but rather interpreters, problem solvers, and advisers

Many readers will be accessing the MJA via the internet: on computers, laptops, phones, or tablets. It is therefore essential that we discuss and understand how the internet and social media are used by patients to find health information, as well as the influence that the medical profession might have on such online information.


  • Emergency medicine consultant, Sydney


Correspondence: sieraci@ozemail.com.au

Competing interests:

I am an executive member of Friends of Science in Medicine.

  • 1. Cocco AM, Zordan R, Taylor DM, et al. Dr Google in the ED: searching for online health information by adult emergency department patients. Med J Aust 2018; 209: 342-347.
  • 2. Thompson A. Hippocrates and the smart phone: the evolving parent and doctor relationship. J Paediatr Child Health 2016; 52: 366-369.
  • 3. Hartzband P, Groopman J. Untangling the web — patients, doctors, and the Internet. N Engl J Med 2010; 362: 1063-1066.
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Subclavian vein thrombosis with internal jugular vein extension in an Australian rules football player

John WP Wong, Fiona WY Lai and Ian Wilson
Med J Aust 2018; 209 (8): . || doi: 10.5694/mja18.00335
Published online: 15 October 2018

Clinical record


  • 1 Royal Melbourne Hospital, Melbourne, VIC
  • 2 Northeast Health Wangaratta, Wangaratta, VIC
  • 3 Rural Health, University of Melbourne, Shepparton, VIC


Correspondence: johnwpwong@gmail.com

Competing interests:

No relevant disclosures.

  • 1. Esmon CT. Basic mechanisms and pathogenesis of venous thrombosis. Blood Rev 2009; 23: 225-229.
  • 2. Bernardi E, Pesavento R, Prandoni P. Upper extremity deep venous thrombosis. Semin Thromb Hemost 2006; 32: 729-736.
  • 3. Lindblad B, Tengborn L, Bergqvist D. Deep vein thrombosis of the axillary-subclavian veins: epidemiologic data, effects of different types of treatment and late sequelae. Eur J Vasc Surg 1998; 2: 161-165.
  • 4. Alla VM, Natarajan N, Kaushik M, et al. Paget–Schroetter syndrome: review of pathogenesis and treatment of effort thrombosis. West J Emerg Med 2010; 11: 358-362.
  • 5. Héron E, Lozinguez O, Alhenc-Gelas M, et al. Hypercoaguable states in primary upper-extremity deep vein thrombosis. Arch Intern Med 2000; 160: 382-386.
  • 6. Elman EE, Kahn SR. The post-thrombotic syndrome after upper extremity deep venous thrombosis in adults: a systematic review. Thromb Res 2006; 117: 609-614.
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Australia is responding to the complex challenge of overdiagnosis

Ray Moynihan, Alexandra L Barratt, Rachelle Buchbinder, Stacy M Carter, Thomas Dakin, Jan Donovan, Adam G Elshaug, Paul P Glasziou, Christopher G Maher, Kirsten J McCaffery and Ian A Scott
Med J Aust 2018; 209 (8): . || doi: 10.5694/mja17.01138
Published online: 15 October 2018

An Australian alliance of clinical, consumer, research and public organisations is emerging to tackle overdiagnosis

Overdiagnosis is now a health challenge recognised across many nations.1 Debates about its definition continue, but in short, overdiagnosis happens when health systems routinely diagnose people in ways that do not benefit them or that even do more harm than good.2 Overdiagnosis is unwarranted diagnosis, leading to harms from unnecessary labels and treatments and to the waste of health care resources that could be better spent dealing with genuine needs. To manage overdiagnosis and the sustainability of the health system more broadly, reversing the harm of too much medicine is becoming a health care priority, demanding effective responses in policy and practice. In Australia, a new alliance is developing a national plan to deal with this problem.


  • 1 Centre for Research in Evidence-Based Practice, Bond University, Gold Coast, QLD
  • 2 University of Sydney, Sydney, NSW
  • 3 Cabrini Institute, Melbourne, VIC
  • 4 Monash University, Melbourne, VIC
  • 5 University of Wollongong, Wollongong, NSW
  • 6 Consumers Health Forum of Australia, Canberra, ACT
  • 7 Menzies Centre for Health Policy, University of Sydney, Sydney, NSW
  • 8 George Institute for Global Health, University of Sydney, Sydney, NSW
  • 9 Princess Alexandra Hospital, Brisbane, QLD
  • 10 University of Queensland, Brisbane, QLD


Correspondence: RayMoynihan@bond.edu.au

Competing interests:

All authors were involved in planning the 2017 National Summit on Overdiagnosis.

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