MJA
MJA

Licence to swill: James Bond’s drinking over six decades

Nick Wilson, Anne Tucker, Deborah Heath and Peter Scarborough
Med J Aust 2018; 209 (11): . || doi: 10.5694/mja18.00947
Published online: 10 December 2018

Abstract

Objectives: To describe the patterns of alcohol use in James Bond movies over six decades.

Design: Film content analysis.

Setting: Wide range of international locations in 24 James Bond movies (Eon Productions series, 1962–2015).

Main outcome measures: Drinking episodes for Bond and major female characters; alcohol product placement in films; peak estimated blood alcohol concentrations; features relevant to DSM-5 criteria for alcohol use disorder.

Results: Bond has drunk heavily and consistently across six decades (109 drinking events; mean, 4.5 events per movie). His peak blood alcohol level was estimated to have been 0.36 g/dL, sufficient to kill some people. We classified him as having severe alcohol use disorder, as he satisfied six of 11 DSM-5 criteria for this condition. Chronic risks for Bond include frequently drinking prior to fights, driving vehicles (including in chases), high stakes gambling, operating complex machinery or devices, contact with dangerous animals, extreme athletic performance, and sex with enemies, sometimes with guns or knives in the bed. Notable trends during the study period included a decline in using alcohol as a weapon (P = 0.023) and an increase in the number of alcohol products in his environment (for alcohol-related product placement: P < 0.001), but his martini consumption has been steady. Drinking by lead female characters and a random selection of 30 of his sexual partners was fairly stable over time, but also occasionally involved binges.

Conclusions: James Bond has a severe chronic alcohol problem. He should consider seeking professional help and find other strategies for managing on-the-job stress.

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The emergence and characteristics of the Australian Mamil

Adrian E Bauman, Katrina Blazek, Lindsey Reece and William Bellew
Med J Aust 2018; 209 (11): . || doi: 10.5694/mja18.00841
Published online: 10 December 2018

Abstract

Background: The Mamil (middle-aged man in Lycra) appears to be an emergent cycling-focused species.

Objectives: To explore the nature and distribution of the Mamilian species; to determine whether rates of cycling by middle-aged men in Australia have changed since the pre-Mamilian era.

Setting: Secondary analysis of representative population-based datasets. National sport participation data from the Exercise, Recreation and Sport (2002–2004, 2008–2010) and Ausplay surveys (2016) were analysed to assess trends in recreational and exercise-related cycling, including by middle-aged men (45–64 years of age). Data from New South Wales Population Health Surveys (2006, 2010, 2014) and Australian censuses (2006, 2011, 2014) were analysed to assess trends in cycling to work.

Main outcome measures: Cycling participation rates (at least once or at least once a week in the past 12 months); rates of cycling to work.

Results: The proportion of middle-aged men who cycled for exercise or recreational purposes at least once a week during the previous year increased from 6.2% (95% CI, 5.5–7.0%) during 2002–2004 to 13.2% (95% CI, 11.9–14.6%) in 2016. The prevalence of Mamils in the most affluent residential areas has more than doubled since 2002–2004, and is twice as high as in the least advantaged locations. Media reports of “Mamils” corroborate these temporal trends.

Discussion: Mamils in Australia are socially graded, and also grade themselves according to bicycle-related expenditure and hill gradients overcome. They often form cohesive and supportive groups, but may not reflect a population-wide social movement to increase physical activity among adult Australians.

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  • 1 University of Sydney, Sydney, NSW
  • 2 New South Wales Ministry of Health, Sydney, NSW


Correspondence: adrian.bauman@sydney.edu.au

Acknowledgements: 

This work was completed while Katrina Blazek was employed as a trainee in the NSW Biostatistics Training Program funded by the NSW Ministry of Health. She undertook this work while based at the Prevention Research Collaboration, Charles Perkins Centre at the School of Public Health, the University of Sydney. We thank several (medically) “specialised” Mamils who provided anonymous source material.

Competing interests:

Between us, we own up to having four functional bicycles, with a total value of no more than $1200, substantially less than that of a single set of the Mavic Aksium wheels often seen on Mamilian bicycles.

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Adding kindness at handover to improve our collegiality: the K-ISBAR tool

David J Brewster and Bruce P Waxman
Med J Aust 2018; 209 (11): . || doi: 10.5694/mja18.00755
Published online: 10 December 2018

Much has been written recently about the mental health of the Australian medical workforce, with doctors being burned out, bullied, harassed and mentally unwell.1,2 Why are doctors so unkind to each other? What has happened to collegiality? While we are from different medical backgrounds, we are united in the belief that it is time for change; time for a united response from the Australian medical profession focusing on collegiality, using kindness and understanding as the catalyst and clinical handover as the opportunity.


  • 1 Cabrini Clinical School, Monash University, Melbourne, VIC
  • 2 Cabrini Health, Melbourne, VIC
  • 3 School of Clinical Sciences at Monash Health, Monash University, Melbourne, VIC


Correspondence: dbrewster@cabrini.com.au

Acknowledgements: 

We thank Dr Malcolm Clark for his contribution to an earlier draft of this article.

Competing interests:

No relevant disclosures.

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From the curious case of Patient K to TOP GEAR and Bond

Nicholas J Talley AC
Med J Aust 2018; 209 (11): . || doi: 10.5694/mja18.01086
Published online: 10 December 2018

Celebrating a great year for the MJA with our 2018 holiday issue

Welcome to the traditional summer edition of the MJA! In place of all the ground-breaking research, expert reviews, meta-analyses, and penetrating perspectives we publish throughout the year, we present a fascinating potpourri of the amusing and interesting articles and commentaries we have received as entries for our annual Christmas competition, before reviewing the best research we published during 2018.

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  • Editor-in-Chief, the Medical Journal of Australia, on behalf of the MJA Editorial team


Correspondence: ntalley@mja.com.au

Competing interests:

No relevant disclosures for this article. A complete list of my conflict of interest disclosures is found at

  • 1. Wilson N, Tucker D, Heath D, Scarborough P. License to swill: James Bond’s drinking over six decades. Med J Aust 2018; 209: 495-500.
  • 2. Ellis M, Sun M, Wood M, Chan WO. The Observational Physician and surGEon Automobile Response (TOP GEAR) survey. Med J Aust 2018; 209: 503-505.
  • 3. Teo SS, Manivel V. C-ABC: cash before care in a private emergency department? Med J Aust 2018; 209: 509-510.
  • 4. Bauman AE, Blazek K, Reece L, Bellew W. The emergence and characteristics of the Australian Mamil. Med J Aust 2018; 209; 490-494.
  • 5. Elisha R. The curious case of patient K. Med J Aust 2018; 209: 501-502.
  • 6. Cairns R, Brown JA, Dawson AH, et al. Carols by glow sticks: a retrospective analysis of Poisons Information Centre data. Med J Aust 2018; 209: 505-508.
  • 7. Prince SA. The Christmas e-list (an ode to big data). Med J Aust 2018; 209: 510.
  • 8. Tong EY, Roman CP, Mitra B, et al. Reducing medication errors in hospital discharge summaries: a randomised controlled trial. Med J Aust 2017; 206: 36-39. <MJA full text>
  • 9. Chanchlani S, Chang D, Ong JSL, Anwar A. The value of peer mentoring for the psychosocial wellbeing of junior doctors: a randomised controlled study. Med J Aust 2018; 209: 401-405. <MJA full text>
  • 10. Khan E, Brieger D, Amerena J, et al. Differences in management and outcomes for men and women with ST-elevation myocardial infarction. Med J Aust 2018; 209: 118-123. <MJA full text>
  • 11. Huynh Q, Negishi K, De Pasquale C, et al. Effects of post-discharge management on rates of early re-admission and death after hospitalisation for heart failure. Med J Aust 2018; 208: 485-491. <MJA full text>
  • 12. Davis K, Remenyi B, Draper ADK, et al. Rheumatic heart disease in Timor-Leste school students: an echocardiography-based prevalence study. Med J Aust 2018; 208: 303-307. <MJA full text>
  • 13. Zbrojkiewicz D, Vertullo C, Grayson JE. Increasing rates of anterior cruciate ligament reconstruction in young Australians, 2000–2015. Med J Aust 2018; 208: 354-358. <MJA full text>
  • 14. Cheney K, Farber R, Barratt AL, et al. Population attributable fractions of perinatal outcomes for nulliparous women associated with overweight and obesity, 1990–2014. Med J Aust 2018; 208: 119-125. <MJA full text>
  • 15. Davies SJ, Lum JAG, Skouteris H, et al. Cognitive impairment during pregnancy: a meta-analysis. Med J Aust 2018; 208: 35-40. <MJA full text>
  • 16. Hong TP, Gow PJ, Fink M, et al. Surveillance improves survival of patients with hepatocellular carcinoma: a prospective population-based study. Med J Aust 2018; 209: 348-354. <MJA full text>
  • 17. Evans MA, Millar JL, Earnest A, et al. Active surveillance of men with low risk prostate cancer: evidence from the Prostate Cancer Outcomes Registry–Victoria. Med J Aust 2018; 208: 439-443. <MJA full text>
  • 18. Curchin DJ, Harris VR, McCormack CJ, Smith SD. Changing trends in the incidence of invasive melanoma in Victoria, 1985–2015. Med J Aust 2018; 208: 265-269. <MJA full text>
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Methods of melanoma detection and of skin monitoring for individuals at high risk of melanoma: new Australian clinical practice guidelines

Nikki R Adler, John W Kelly, Pascale Guitera, Scott W Menzies, Alex J Chamberlain, Paul Fishburn, Alison E Button‐Sloan, Clinton Heal, H Peter Soyer and John F Thompson
Med J Aust 2019; 210 (1): . || doi: 10.5694/mja2.12033
Published online: 2 December 2018

Abstract

Introduction: The evidence‐based national clinical practice guidelines for the management of cutaneous melanoma published in 2008 are currently being updated. This article summarises the findings from multiple chapters of the guidelines on different methods of melanoma detection and of monitoring the skin for patients at high risk of melanoma. Early detection of melanoma is critical, as thinner tumours are associated with enhanced survival; therefore, strategies to improve early detection are important to reduce melanoma‐related mortality.

Main recommendations:

  • Clinicians who perform skin examinations for the purpose of detecting skin cancer should be trained in and use dermoscopy.
  • The use of short term sequential digital dermoscopy imaging to detect melanomas that lack dermoscopic features of melanoma is recommended to assess individual melanocytic lesions of concern.
  • The use of long term sequential digital dermoscopy imaging to detect melanomas that lack dermoscopic features of melanoma is recommended to assess individual or multiple melanocytic lesions for routine surveillance of high risk patients.
  • The use of total body photography should be considered in managing patients at increased risk for melanoma, particularly those with high naevus counts and dysplastic naevi.
  • There is insufficient evidence to recommend the routine use of automated instruments for the clinical diagnosis of primary melanoma.

 

Management overview: Determining the relative indications for each diagnostic method and how each method should be introduced into the surveillance of a patient requires careful consideration and an individualised approach.


  • 1 Victorian Melanoma Service, Alfred Hospital, Melbourne, VIC
  • 2 Armadale Dermatology, Melbourne, VIC
  • 3 Melanoma Institute Australia, Sydney, NSW
  • 4 University of Sydney, Sydney, NSW
  • 5 Royal Prince Alfred Hospital, Sydney, NSW
  • 6 Sydney Melanoma Diagnostic Centre, University of Sydney, Sydney, NSW
  • 7 Victorian Melanoma Service, Alfred Health, Melbourne, VIC
  • 8 Glenferrie Dermatology, Melbourne, VIC
  • 9 Norwest Skin Cancer Centre, Sydney, NSW
  • 10 Melanoma Patients Australia, Brisbane, QLD
  • 11 MelanomaWA, Perth, WA
  • 12 Dermatology Research Centre, Diamantina Institute, University of Queensland, Brisbane, QLD
  • 13 Princess Alexandra Hospital, Brisbane, QLD


Correspondence: nikki.adler@monash.edu

Acknowledgements: 

The development of the new Australian clinical practice guidelines for the diagnosis and management of melanoma was funded by Cancer Council Australia and the Melanoma Institute Australia, with additional support from the Skin Cancer College Australasia and the Australasian College of Dermatologists. Nikki Adler is supported by a Research Training Program stipend scholarship, Monash University. H Peter Soyer has an NHMRC Practitioner Fellowship. John Thompson is supported by the Melanoma Foundation at the University of Sydney.

Competing interests:

No relevant disclosures.

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Forty years of “Waltzing Matilda”: the history of the multichannel cochlear implant

Joyce PK Ho, Hannah North and Narinder P Singh
Med J Aust 2018; 209 (11): . || doi: 10.5694/mja18.00365
Published online: 3 December 2018

The fascinating history of the multichannel cochlear implant and its inventor, Professor Graeme Clark

A cochlear implant is a surgically implanted device for converting sounds into an electrical current that directly stimulates the cochlear nerve.1 It consists of external (microphone, speech processor, transmitter) and internal components (receiver/stimulator, electrode array in the cochlea) and can be implanted in both children and adults.


  • 1 Westmead Hospital, Sydney, NSW
  • 2 Westmead Clinical School, University of Sydney, Sydney, NSW
  • 3 Ear Nose & Throat Sydney, Sydney, NSW



Acknowledgements: 

All images provided courtesy of Cochlear Limited.

Competing interests:

No relevant disclosures.

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  • 8. Clark GM. Responses of cells in the superior olivary complex of the cat to electrical stimulation of the auditory nerve. Exp Neurol 1969; 24: 124-136.
  • 9. Clark GM, Hallwoeth RJ, Zdanius K. A cochlear implant electrode. J Laryngol Otol 1975; 89: 787-792.
  • 10. Clark GM. Personal reflections on the multichannel cochlear implant and a view of the future. J Rehabil Res Dev 2008; 45: 651-693.
  • 11. Clark GM, Pyman, BC, Bailey QR. The surgery for multiple-electrode cochlear implantations. J Laryngol Otol 1979; 93: 215-223.
  • 12. Tong YC, Black RC, Clark GM, et al. A preliminary report on a multiple-channel cochlear implant operation. J Laryngol Otol 1979; 93: 679-695.
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The MJA–Lancet Countdown on health and climate change: Australian policy inaction threatens lives

Ying Zhang, Paul J Beggs, Hilary Bambrick, Helen L Berry, Martina K Linnenluecke, Stefan Trueck, Robyn Alders, Peng Bi, Sinead M Boylan, Donna Green, Yuming Guo, Ivan C Hanigan, Elizabeth G Hanna, Arunima Malik, Geoffrey G Morgan, Mark Stevenson, Shilu Tong, Nick Watts and Anthony G Capon
Med J Aust 2018; 209 (11): . || doi: 10.5694/mja18.00789
Published online: 29 November 2018

Summary

 

  • Climate plays an important role in human health and it is well established that climate change can have very significant impacts in this regard. In partnership with The Lancet and the MJA, we present the inaugural Australian Countdown assessment of progress on climate change and health.
  • This comprehensive assessment examines 41 indicators across five broad sections: climate change impacts, exposures and vulnerability; adaptation, planning and resilience for health; mitigation actions and health co-benefits; economics and finance; and public and political engagement.
  • These indicators and the methods used for each are largely consistent with those of the Lancet Countdown global assessment published in October 2017, but with an Australian focus. Significant developments include the addition of a new indicator on mental health.
  • Overall, we find that Australia is vulnerable to the impacts of climate change on health, and that policy inaction in this regard threatens Australian lives. In a number of respects, Australia has gone backwards and now lags behind other high income countries such as Germany and the United Kingdom. Examples include the persistence of a very high carbon-intensive energy system in Australia, and its slow transition to renewables and low carbon electricity generation. However, we also find some examples of good progress, such as heatwave response planning.
  • Given the overall poor state of progress on climate change and health in Australia, this country now has an enormous opportunity to take action and protect human health and lives. Australia has the technical knowhow and intellect to do this, and our annual updates of this assessment will track Australia’s engagement with and progress on this vitally important issue.

 

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  • 1 School of Public Health, University of Sydney, Sydney, NSW
  • 2 Department of Environmental Sciences, Macquarie University, Sydney, NSW
  • 3 School of Public Health and Social Work, Queensland University of Technology, Brisbane, QLD
  • 4 Department of Applied Finance, Macquarie University, Sydney, NSW
  • 5 International Rural Poultry Centre, Kyeema Foundation, Brisbane, QLD
  • 6 Centre for Global Health Security, Chatham House, London, UK
  • 7 School of Public Health, University of Adelaide, Adelaide, SA
  • 8 Climate Change Research Centre, ARC Centre of Excellence for Climate Extremes, University of New South Wales, Sydney, NSW
  • 9 Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC
  • 10 University Centre for Rural Health, University of Sydney, Sydney, NSW
  • 11 Climate Change Institute, Australian National University, Canberra, ACT
  • 12 School of Physics, University of Sydney, Sydney, NSW
  • 13 University Centre for Rural Health, University of Sydney, Lismore, NSW
  • 14 Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC
  • 15 Department of Clinical Epidemiology and Biostatistics, Shanghai Jiao Tong University, Shanghai, China
  • 16 Institute of Environment and Population Health, Anhui Medical University, Hefei, China
  • 17 Institute of Global Health, University College London, London, UK


Correspondence: ying.zhang@sydney.edu.au

Acknowledgements: 

We thank Dr Elizabeth Ebert (Australian Bureau of Meteorology) for contributing indicator 2.4 (Climate information services for health). We also thank Dr Luke Knibbs (University of Queensland) who provided assistance with the PM monitor data for indicator 3.5.1 (Exposure to air pollution in cities). Indicator 3.9 (Health care sector emissions) builds on Malik et al ( 2018; 2: e27–e35) and we would like to acknowledge the co-authors of that publication: Prof Manfred Lenzen, Dr Forbes McGain and Scott McAlister. We would also like to acknowledge Fabiola Barba Ponce (Macquarie University).

Competing interests:

Anthony Capon directs the human health and social impacts research node of the NSW Adaptation Research Hub.

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Reducing cardiovascular risk in people with diabetes and kidney disease

Brendon L Neuen and Vlado Perkovic
Med J Aust 2018; 209 (10): . || doi: 10.5694/mja18.00929
Published online: 19 November 2018

We need to move beyond managing end organ complications to reducing cardio-renal risk across the spectrum of kidney function

Type 2 diabetes mellitus is one of the greatest challenges facing the Australian health care system. The number of Australians living with diabetes has tripled over the past 25 years, and by 2025 it is expected that 3 million adults will have been diagnosed with the disease, one of the most rapid rises for any chronic condition in Australia.1


  • The George Institute for Global Health, Sydney, NSW



Acknowledgements: 

Brendon Neuen is funded by a John Chalmers PhD Scholarship from the George Institute for Global Health and a University Postgraduate Award from UNSW Sydney. Vlado Perkovic receives research support from the National Health and Medical Research Council (Senior Research Fellowship and Program Grant).

Competing interests:

The George Institute for Global Health provides contract research services to Janssen for trials of sodium/glucose cotransporter 2 (SGLT2) inhibitors. Brendon Neuen receives travel support from Janssen. Vlado Perkovic is the chair of a steering committee for a renal outcome study of an SGLT2 inhibitor (canagliflozin), serves on steering committees for AbbVie, Boehringer Ingelheim, GlaxoSmithKline, Janssen and Pfizer, and serves on advisory boards or speaks at scientific meetings for AbbVie, Astellas, AstraZeneca, Bayer, Baxter, Bristol-Myers Squibb, Boehringer Ingelheim, Durect, Eli Lilly, Gilead, GlaxoSmithKline, Janssen, Merck, Novartis, Novo Nordisk, Pfizer, Pharmalink, Relypsa, Roche, Sanofi, Servier and Vitae; all honoraria for these activities are paid to the George Institute for Global Health.


  • 1. Baker IDI Heart and Diabetes Institute, Diabetes Australia, Juvenile Diabetes Research Foundation. Diabetes: the silent pandemic and its impact on Australia. 2012. https://baker.edu.au/-/media/documents/impact/diabetes-the-silent-pandemic.ashx?la=en (viewed Sept 2018).
  • 2. Thomas MC, Cooper ME, Zimmet P. Changing epidemiology of type 2 diabetes mellitus and associated chronic kidney disease. Nat Rev Nephrol 2016; 12: 73-81.
  • 3. Kidney Health Australia. The economic impact of end-stage kidney disease in Australia: projections to 2020. 2010. https://kidney.org.au/cms_uploads/docs/kha-economic-impact-of-eskd-in-australia-projections-2020.pdf (viewed Sept 2018).
  • 4. Lim WH, Johnson DW, Hawley C, et al. Type 2 diabetes in patients with end-stage kidney disease: influence on cardiovascular disease-related mortality risk. Med J Aust 2018; 209: 440-446.
  • 5. Lascar N, Brown J, Pattison H, et al. Type 2 diabetes in adolescents and young adults. Lancet Diabetes Endocrinol 2018; 6: 69-80.
  • 6. Wanner C, Tonelli M. KDIGO clinical practice guideline for lipid management in CKD: summary of recommendation statements and clinical approach to the patient. Kidney Int 2014; 85: 1303-1309.
  • 7. Heerspink HJL, Ninomiya T, Zoungas S, et al. Effect of lowering blood pressure on cardiovascular events and mortality in patients on dialysis: a systematic review and meta-analysis of randomised controlled trials. Lancet 2009; 373: 1009-1015.
  • 8. Palmer SC, Di Micco L, Razavian M, et al. Effects of antiplatelet therapy on mortality and cardiovascular and bleeding outcomes in persons with chronic kidney disease: a systematic review and meta-analysis. Ann Intern Med 2012; 156: 445-459.
  • 9. O’Lone E, Viecelli AK, Craig JC, et al. Cardiovascular outcomes reported in hemodialysis trials. J Am Coll Cardiol 2018; 71: 2802-2810.
  • 10. Tong A, Manns B, Hemmelgarn B, et al. Establishing core outcome domains in hemodialysis: report of the Standardized Outcomes in Nephrology–Hemodialysis (SONG-HD) consensus workshop. Am J Kidney Dis 2017; 69: 97-107.
  • 11. American Diabetes Association. Pharmacologic approaches to glycemic treatment: standards of medical care in diabetes — 2018. Diabetes Care 2018; 41: S73-S85.
  • 12. Diabetes Canada Clinical Practice Guidelines Expert Committee; Lipscombe L, Booth G, Butalia S, et al. Pharmacologic glycemic management of type 2 diabetes in adults. Can J Diabetes 2018; 42: S88-S103.
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Deprescribing proton pump inhibitors: why, when and how

Peter Bytzer
Med J Aust 2018; 209 (10): . || doi: 10.5694/mja18.00674
Published online: 12 November 2018

The focus should primarily be on avoiding unnecessary long term prescribing of PPIs

For more than 25 years, proton pump inhibitors (PPIs) have been the mainstay of therapy for acid-related disorders, particularly peptic ulcer disease and gastro-oesophageal reflux disease (GORD). In recent decades, prescribing of PPIs has increased considerably around the world. According to a recent national drug utilisation study, prescribing of PPIs increased fourfold in Denmark between 2002 and 2014, with the increase particularly marked among older patients; 7% of all adults and 14% of adults over 60 were covered by PPI prescriptions.1 The increased prescribing of PPIs is driven primarily by the accumulation of existing users rather than by new users; inappropriate prescribing and long term use, rather than genuine clinical need for ulcer prophylaxis, appear to underlie the high prevalence of PPI prescribing.2 Changes to public subsidisation of PPI costs and interventions for improving adherence to guidelines and promoting the rational use of PPIs have not had a substantial influence on prescribing patterns.


  • University of Copenhagen, Køge, Denmark


Correspondence: pmby@regionsjaelland.dk

Competing interests:

No relevant disclosures.

  • 1. Pottegård A, Broe A, Hallas J, et al. Use of proton-pump inhibitors among adults: a Danish nationwide drug utilization study. Therap Adv Gastroenterol 2016; 9: 671-678.
  • 2. Batuwitage BT, Kingham JG, Morgan NE, Bartlett RL. Inappropriate prescribing of proton pump inhibitors in primary care. Postgrad Med J 2007; 83: 66-68.
  • 3. Vaezi, MF, Yang YX, Howden CW. Complications of proton pump inhibitor therapy. Gastroenterology 2017; 153: 35-48.
  • 4. Reimer C. Safety of long-term PPI therapy. Best Pract Res Clin Gastroenterol 2013; 27: 443-454.
  • 5. Lødrup AB, Reimer C, Bytzer P. Systematic review: symptoms of rebound acid hypersecretion following proton pump inhibitor treatment. Scand J Gastroenterol 2013; 48: 515-522.
  • 6. Haastrup P, Paulsen MS, Begtrup LM, et al. Strategies for discontinuation of proton pump inhibitors: a systematic review. Fam Pract 2014; 31: 625-630.
  • 7. Reimer C, Bytzer P. Discontinuation of long-term proton pump inhibitor therapy in primary care patients: a randomized placebo-controlled trial in patients with symptom relapse. Eur J Gastroenterol Hepatol 2010; 22: 1182-1188.
  • 8. Murie J, Allen J, Simmonds R, de Wet C. Glad you brought it up: a patient-centred programme to reduce proton-pump inhibitor prescribing in general medical practice. Qual Prim Care 2012; 20: 141-148.
  • 9. Björnsson E, Abrahamsson H, Simrén M, et al. Discontinuation of proton pump inhibitors in patients on long-term therapy: a double-blind, placebo-controlled trial. Aliment Pharmacol Ther 2006; 24: 945-954.
  • 10. Inadomi, JM, Jamal R, Murata GH, et al. Step-down management of gastroesophageal reflux disease. Gastroenterology 2001; 121: 1095-1100.
  • 11. National Prescribing Service. Reviewing PPIs for GORD. June 2018. https://cdn0.scrvt.com/08ab3606b0b7a8ea53fd0b40b1c44f86/c052d66150fd152a/df9dd3c72fab/Reviewing-PPIs-for-GORD-algorithm-June-2018.pdf (viewed July 2018).
  • 12. Bytzer P. Goals of therapy and guidelines for treatment success in symptomatic gastroesophageal reflux disease patients. Am J Gastroenterol 2003; 98(3 Suppl): S31-S39.
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Gluten in “gluten-free” manufactured foods in Australia: a cross-sectional study

Emma P Halmos, Dean Clarke, Catherine Pizzey and Jason A Tye-Din
Med J Aust 2018; 209 (10): . || doi: 10.5694/mja18.00457
Published online: 12 November 2018

Patients with coeliac disease must strictly adhere to a gluten-free diet. Two potential sources of inadvertent gluten exposure are meals provided when dining out and manufactured “gluten-free” foods. A recent study1 found that 9% of gluten-free food samples from Melbourne food businesses failed to meet the national standard of “no detectable gluten”2. As no data on gluten levels in manufactured “gluten-free” foods in Australia have been published, we measured the gluten content of a broad sample of these foods.

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  • 1 Royal Melbourne Hospital, Melbourne, VIC
  • 2 Monash University Central Clinical School, Melbourne, VIC
  • 3 National Measurement Institute, Melbourne, VIC
  • 4 Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC


Correspondence: tyedin@wehi.edu.au

Acknowledgements: 

Emma Halmos was funded by a research grant from Coeliac Australia. We thank the Nielsen Company for their data on the most commonly purchased foods; and Martina Koeberl, Jasmit Khangurha and Rasika Wijerathne (National Measurement Institute) for conducting the food analyses.

Competing interests:

Jason Tye-Din is a co-inventor on patents pertaining to applications of gluten peptides in therapeutics, diagnostics, and non-toxic gluten; he is a shareholder in Nexpep and a consultant to ImmusanT (USA).

  • 1. Halmos EP, Di Bella CA, Webster R, et al. Gluten in “gluten-free” food from food outlets in Melbourne: a cross-sectional study. Med J Aust 2018; 209: 42-43. <MJA full text>
  • 2. Food Standards Australia New Zealand. Standard 1.2.7. Nutrition, health and related claims. Nov 2017. https://www.legislation.gov.au/Details/F2017C01048 (viewed Apr 2018).
  • 3. Forbes GM, Dods K. Gluten content of imported gluten-free foods: national and international implications. Med J Aust 2016; 205: 316. <MJA full text>
  • 4. Catassi C, Fabiani E, Iacono G, et al. A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease. Am J Clin Nutr 2007; 85: 160-166.
  • 5. Zurzolo GA, Peters RL, Koplin JJ, et al. The practice and perception of precautionary allergen labelling by the Australasian food manufacturing industry. Clin Exp Allergy 2017; 47: 961-968.
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