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The deleterious effects of cannabis during pregnancy on neonatal outcomes

Luke E Grzeskowiak, Jessica A Grieger, Prabha Andraweera, Emma J Knight, Shalem Leemaqz, Lucilla Poston, Lesley McCowan, Louise Kenny, Jenny Myers, James J Walker, Gustaaf A Dekker and Claire T Roberts
Med J Aust 2020; 212 (11): . || doi: 10.5694/mja2.50624
Published online: 15 June 2020

Abstract

Objectives: To evaluate whether cannabis use during pregnancy is associated with adverse neonatal outcomes that are independent of cigarette smoking.

Design: Prospective cohort study.

Setting: Adelaide (Australia), Auckland (New Zealand), Cork (Ireland), and Leeds, London and Manchester (United Kingdom).

Participants: 5610 pregnant nulliparous women with low risk pregnancies recruited for the Screening for Pregnancy Endpoints (SCOPE) study, November 2004 – February 2011. At 14–16 weeks of pregnancy, women were grouped by self‐reported cannabis use.

Main outcome measures: Infant birthweight, head circumference, birth length, gestational age, and severe neonatal morbidity or mortality.

Results: 314 women (5.6%) reported using cannabis in the 3 months before or during their pregnancy; 97 (31%) stopped using it before and 157 (50%) during the first 15 weeks of pregnancy, while 60 (19%) were still using cannabis at 15 weeks. Compared with babies of mother who had never used cannabis, infants of those who still used it at 15 weeks had lower mean values for birthweight (adjusted mean difference [aMD], –127 g; 95% CI, –238 to –17 g), head circumference (aMD, –0.5 cm; 95% CI, –0.8 to –0.1 cm), birth length (aMD, –0.8 cm; 95% CI, –1.4 to –0.2 cm), and gestational age at birth (aMD, –8.1 days; 95% CI, –12.1 to –4.0 days). The differences for all outcomes except gestational age were greater for women who used cannabis more than once a week than for those who used it less frequently.

Conclusions: Continuing to use cannabis during pregnancy is an independent risk factor for poorer neonatal outcomes.

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Will online symptom checkers improve health care in Australia?

Adam G Dunn
Med J Aust 2020; 212 (11): . || doi: 10.5694/mja2.50621
Published online: 15 June 2020

The available tools are largely unregulated, and do not reliably guide people to the right care at the right time

In times when health services are under increasing strain, digital health technologies such as online symptom checkers appear convenient and cost‐effective tools for reducing the burden on clinics, telemedicine services, and emergency departments. In practical terms, an online symptom checker is a smartphone app or web‐based form that can provide a diagnosis on the basis of a set of self‐reported symptoms. They can suggest diagnoses for a broad range of conditions with which people may present to a clinic or emergency department. When they work properly, symptom checkers should turn current practice guidelines into tools that can diagnose and triage patients at low cost.


  • The University of Sydney, Sydney, NSW


Correspondence: adam.dunn@sydney.edu.au

Competing interests:

No relevant disclosures.

  • 1. Hill MG, Sim M, Mills B. The quality of diagnosis and triage advice provided by free online symptom checkers and apps in Australia. Med J Aust 2020; 213: 514–519.
  • 2. Fraser H, Coiera E, Wong D. Safety of patient‐facing digital symptom checkers. Lancet 2018; 392: 2263–2264.
  • 3. Razzaki S, Baker A, Perov Y, et al. A comparative study of artificial intelligence and human doctors for the purpose of triage and diagnosis [preprint]. 27 June 2018. https://arxiv.org/abs/1806.10698v1 (viewed Apr 2020).
  • 4. McGrath P, Blumer C, Story Carter J. Medical appointment booking app HealthEngine sharing clients’ personal information with lawyers. ABC News [online]. 24 June 2018. https://www.abc.net.au/news/2018-06-25/healthengine-sharing-patients-information-with-lawyers/9894114 (viewed Apr 2020).
  • 5. Meyer AND, Giardina TD, Spitzmueller C, et al. Patient perspectives on the usefulness of an artificial intelligence–assisted symptom checker: cross‐sectional survey study. J Med Internet Res 2020; 22: e14679.
  • 6. Iacobucci G. Row over Babylon's chatbot shows lack of regulation. BMJ 2020; 368: m815.
  • 7. Shuren J, Patel B, Gottlieb S. FDA regulation of mobile medical apps. JAMA 2018; 320: 337–338.
  • 8. Semigran HL, Linder JA, Gidengil C, Mehrotra A. Evaluation of symptom checkers for self diagnosis and triage: audit study. BMJ 2015; 351: h3480.
  • 9. Chambers D, Cantrell AJ, Johnson M, et al. Digital and online symptom checkers and health assessment/triage services for urgent health problems: systematic review. BMJ Open 2019; 9: e027743.
  • 10. Winn AN, Somai M, Fergestrom N, Crotty BH. Associations of use of online symptom checkers with patients’ plans for seeking care. JAMA Network Open 2019; 2: e1918561.
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The vitamin D testing rate is again rising, despite new MBS testing criteria

Louisa Gordon, Mary Waterhouse, Ian R Reid and Rachel E Neale
Med J Aust 2020; 213 (4): . || doi: 10.5694/mja2.50619
Published online: 8 June 2020

The number of tests for vitamin D deficiency in Australia rose steeply between 2000 and 2011, from 0.4 to 36.5 tests per 1000 population; the cost to Medicare increased from $1.1 million in 2000 to $95.6 million in 2010,1 and peaked at $151 million in 2012–13.2 Consequently, the Medical Benefits Schedule (MBS) items for testing (66608, 66609) were replaced in November 2014 by new items (66833–66837) with the aim of restricting testing to people at particular risk of vitamin D deficiency, including those with a history of osteomalacia or osteoporosis, elevated alkaline phosphatase levels, hyperparathyroidism, hypo‐ or hypercalcaemia, hypophosphataemia, malabsorption, chronic renal failure, deeply pigmented skin or chronic and severe lack of sun exposure, or a diagnosis of vitamin D deficiency, and people who used medications that reduce 25‐hydroxyvitamin D levels.3


  • 1 QIMR Berghofer Medical Research Institute, Brisbane, QLD
  • 2 Queensland University of Technology (QUT), Brisbane, QLD
  • 3 The University of Auckland, Auckland, New Zealand
  • 4 The University of Queensland, Brisbane, QLD



Competing interests:

No relevant disclosures.

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Assessing angiotensin‐converting enzyme (ACE) protein is more appropriate than ACE activity when investigating sarcoidosis

Carel J Pretorius and Jacobus PJ Ungerer
Med J Aust 2020; 213 (4): . || doi: 10.5694/mja2.50620
Published online: 8 June 2020

Elevated serum angiotensin‐converting enzyme (ACE) activity, a biomarker for epithelioid granuloma, has a supportive role in the diagnosis and management of sarcoidosis,1 although in population‐based studies its diagnostic usefulness is modest, with positive and negative predictive values of 25.4% and 89.9% respectively.2 Further, elevated ACE activity is non‐specific; it is also found in people with tuberculous and other infectious granulomata, liver disease, lymphoma, diabetes, or hyperthyroidism, and also as a benign familial condition. However, elevated ACE activity can facilitate some clinical decisions, including the diagnosis of Löfgren syndrome or adults with uveitis.1,3

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  • Pathology Queensland, Brisbane, QLD



Competing interests:

No relevant disclosures.

  • 1. Ahmadzai H, Huang S, Steinfort C, et al. Sarcoidosis: a state of the art review from the Thoracic Society of Australia and New Zealand. Med J Aust 2018; 208: 499–504. https://www.mja.com.au/journ​al/2018/208/11/sarco​idosis-state-art-review-thora​cic-socie​ty-austr​alia-and-new-zealand.
  • 2. Ungprasert P, Carmona EM, Crowson CS, Matteson EL. Diagnostic utility of angiotensin‐converting enzyme in sarcoidosis: a population‐based study. Lung 2016; 194: 91–95.
  • 3. Niederer RL, Al‐Janabi A, Lightman SL, Tomkins‐Netzer O. Serum angiotensin‐converting enzyme has a high negative predictive value in the investigation for systemic sarcoidosis. Am J Opthtalmol 2018; 194: 82–87.
  • 4. Lieberman J, Zakria F. Effect of captopril and enalapril medication on the serum ACE test for sarcoidosis. Sarcoidosis 1989; 6: 118–123.
  • 5. Struthers AD, Anderson G, MacFadyen RJ, et al. Non‐adherence with ACE‐inhibitor treatment is common in heart failure and can be detected by routine serum ACE activity assays. Heart 1999; 82: 584–588.
  • 6. Singh H, Spitzmueller C, Petersen NJ, et al. Information overload and missed test results in electronic health record‐based settings. JAMA Intern Med 2013; 173: 702–703.
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Australian residential aged care is understaffed

Kathy Eagar, Anita Westera and Conrad Kobel
Med J Aust 2020; 212 (11): . || doi: 10.5694/mja2.50615
Published online: 1 June 2020

The existing system is failing to deliver the care that Australia expects

Australia's aged care has changed considerably in recent decades. In response to consumer demand, old institutional‐style nursing homes have been progressively phased out in favour of better facilities. Home‐like furnishings and decor and single bedrooms personalised with residents’ own belongings have increasingly become the norm. In the process, they have become residential aged care facilities (RACFs), and there is no longer a distinction between low and high care.1


  • Australian Health Services Research Institute, University of Wollongong, Wollongong, NSW


Correspondence: keagar@uow.edu.au

Acknowledgements: 

The research summarised in this article was funded by the Royal Commission into Aged Care Quality and Safety. This funding was paid to the university and not the authors. The Royal Commission into Aged Care Quality and Safety had no role in the research or in the preparation of the manuscript.

Competing interests:

None declared.

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The challenges of establishing adequate capacity for SARS‐CoV‐2 testing

David W Smith
Med J Aust 2020; 212 (10): . || doi: 10.5694/mja2.50610
Published online: 1 June 2020

The response to COVID‐19 in Australia has been impressive, but our laboratory capacity must be used wisely

Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the virus that causes coronavirus disease 2019 (COVID‐19), has spread rapidly throughout the world from its origins in China in late 2019; the COVID‐19 outbreak was declared a pandemic by the World Health Organization on 11 March 2020.1 It is the seventh coronavirus known to have crossed from animals to humans, and may become the fifth to persist as an endemic human coronavirus.2

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  • 1 University of Western Australia, Perth, WA
  • 2 PathWest Laboratory Medicine WA, Perth, WA



Competing interests:

No relevant disclosures.

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Transfusion support in mass casualty events: lessons for hospital and pathology preparedness from the Bourke Street Mall incident

Linda Saravanan and Amanda Ormerod
Med J Aust 2020; 212 (11): . || doi: 10.5694/mja2.50611
Published online: 25 May 2020

An integrated approach that includes a central role for pathology laboratories is necessary

Mass casualty events (MCEs) are defined as events or other circumstances “where the normal major incident response of one or several health organisations must be augmented by extraordinary measures to maintain an efficient, suitable and sustainable response”.1 Haemorrhage is a leading cause of mortality in MCEs, accounting for almost 50% of deaths in the first 24 hours,2,3 and transfusion emergency preparedness is increasingly recognised as a critical element of an integrated approach to MCEs,4 with timely availability and appropriate delivery of blood components being an essential part of management.


  • 1 Melbourne Pathology, Melbourne, VIC
  • 2 Latrobe Regional Hospital, Traralgon, VIC
  • 3 Dorevitch Pathology, Traralgon, VIC


Correspondence: linda.saravanan@mps.com.au

Competing interests:

No relevant disclosures.

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Presentations to emergency departments by children and young people with food allergy are increasing

Rachel O'Loughlin and Harriet Hiscock
Med J Aust 2020; 213 (1): . || doi: 10.5694/mja2.50604
Published online: 25 May 2020

The prevalence of food allergy among Victorian children is rising.1 In Victoria, children with suspected food allergies can be on hospital outpatient clinic waiting lists for months before being assessed.2 This may lead families to consider alternative avenues, which can lead to poor allergy management and the need for emergency care. Increasing numbers of Victorian children are presenting to emergency departments,3 but we do not know whether the number visiting with food allergy is also rising.

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  • 1 Royal Children's Hospital Melbourne, Melbourne, VIC
  • 2 Murdoch Children's Research Institute, Melbourne, VIC


Correspondence: harriet.hiscock@rch.org.au

Acknowledgements: 

Harriet Hiscock is supported by a National Health and Medical Research Council Practitioner Fellowship (1136222). The Health Services Research Unit is funded by the Royal Children's Hospital Foundation. The Murdoch Children's Research Institute is supported by the Victorian Government Operational Infrastructure Support Program.

Competing interests:

No relevant disclosures.

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Beyond skin deep: addressing comorbidities in psoriasis

Tom Kovitwanichkanont, Alvin H Chong and Peter Foley
Med J Aust 2020; 212 (11): . || doi: 10.5694/mja2.50591
Published online: 11 May 2020

Summary

  • Psoriasis is a chronic inflammatory disease that is commonly encountered in primary care and is associated with significant morbidity that extends beyond the skin manifestations.
  • Psoriasis is associated with an elevated risk of psoriatic arthritis, cardiovascular disease, obesity, insulin resistance, mental health disorders, certain types of malignancy, inflammatory bowel disease and other immune‐related disorders, and hepatic and renal disease.
  • Enhanced recognition of these comorbidities may lead to earlier diagnosis and potentially better overall health outcomes.
  • Psoriatic nail involvement, severe skin disease and obesity are associated with a greater risk of psoriatic arthritis. Individuals with psoriasis should be routinely screened for psoriatic arthritis to allow for early intervention to improve long term prognosis.
  • Life expectancy is reduced in people with psoriasis due to a variety of causes, with cardiovascular disease and malignancy being the most common aetiologies.
  • Psoriasis affects several factors that contribute to worsened quality of life and increased risk of depression and anxiety. Effective therapies are now available that have been shown to concurrently improve skin disease, quality of life and psychiatric symptoms.
  • As the concordance between psychosocial impact and objective disease severity does not always correlate, it is essential to tailor management strategies specifically to the needs of each individual.
  • Cigarette smoking and excess alcohol consumption are among the most important modifiable risk factors that increase the likelihood of psoriasis development and severity of skin disease. This provides a compelling rationale for smoking cessation and limiting alcohol intake in people with psoriasis beyond their traditional harmful health consequences.

  • 1 Skin Health Institute, Melbourne, VIC
  • 2 St Vincent's Hospital, Melbourne, VIC



Competing interests:

Peter Foley is a consultant, investigator, speaker and/or advisor for, and/or received travel grants from 3M/iNova/Valeant, Abbott/AbbVie, Amgen, Biogen, Bristol Myers Squibb, Boehringer Ingelheim, Celgene, Celtaxsys, Cutanea, Dermira, Eli Lilly, Galderma, GSK/Stiefel, Janssen, LEO Pharma/Peplin, Novartis, Regeneron Pharmaceuticals, Roche, Sanofi Genzyme, Schering‐Plough/MSD, Sun Pharma, UCB and Wyeth/Pfizer.

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Marked variation in out‐of‐pocket costs for cancer care in Western Australia

Neli S Slavova‐Azmanova, Jade C Newton and Christobel M Saunders
Med J Aust 2020; 212 (11): . || doi: 10.5694/mja2.50590
Published online: 4 May 2020

Out‐of‐pocket expenses for cancer care are of growing concern for patients, clinicians, service providers, non‐governmental organisations, private insurers, and politicians. Contrary to popular belief, there is no direct link between the cost and quality of care. Out‐of‐pocket expenses are a particular problem for patients who live further from treatment centres, are younger, or have later stage disease.1

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  • The University of Western Australia, Perth, WA



Acknowledgements: 

Our investigation was funded by the Cancer Council of Western Australia and the WA Cancer and Palliative Care Network.

Competing interests:

No relevant disclosures.

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