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Screening, assessment and management of type 2 diabetes mellitus in children and adolescents: Australasian Paediatric Endocrine Group guidelines

Alexia S Peña, Jacqueline A Curran, Michelle Fuery, Catherine George, Craig A Jefferies, Kristine Lobley, Karissa Ludwig, Ann M Maguire, Emily Papadimos, Aimee Peters, Fiona Sellars, Jane Speight, Angela Titmuss, Dyanne Wilson, Jencia Wong, Caroline Worth and Rachana Dahiya
Med J Aust 2020; 213 (1): . || doi: 10.5694/mja2.50666
Published online: 6 July 2020

Abstract

Introduction: The incidence of type 2 diabetes mellitus has increased in children and adolescents due largely to the obesity epidemic, particularly in high risk ethnic groups. β‐Cell function declines faster and diabetes complications develop earlier in paediatric type 2 diabetes compared with adult‐onset type 2 diabetes. There are no consensus guidelines in Australasia for assessment and management of type 2 diabetes in paediatric populations and health professionals have had to refer to adult guidelines. Recent international paediatric guidelines did not address adaptations to care for patients from Indigenous backgrounds.

Main recommendations: This guideline provides advice on paediatric type 2 diabetes in relation to screening, diagnosis, diabetes education, monitoring including targets, multicomponent healthy lifestyle, pharmacotherapy, assessment and management of complications and comorbidities, and transition. There is also a dedicated section on considerations of care for children and adolescents from Indigenous background in Australia and New Zealand.

Changes in management as a result of the guidelines: Published international guidelines currently exist, but the challenges and specifics to care for children and adolescents with type 2 diabetes which should apply to Australasia have not been addressed to date. These include:

  • recommendations regarding care of children and adolescents from Indigenous backgrounds in Australia and New Zealand including screening and management;
  • tighter diabetes targets (glycated haemoglobin, ≤ 48 mmol/mol [≤ 6.5%]) for all children and adolescents;
  • considering the use of newer medications approved for adults with type 2 diabetes under the guidance of a paediatric endocrinologist; and
  • the need to transition adolescents with type 2 diabetes to a diabetes multidisciplinary care team including an adult endocrinologist for their ongoing care.

  • 1 Robinson Research Institute, University of Adelaide, Adelaide, SA
  • 2 Women's and Children's Hospital, Adelaide, SA
  • 3 Perth Children's Hospital, Perth, WA
  • 4 Queensland Children's Hospital, Brisbane, QLD
  • 5 Starship Children's Health, Auckland, New Zealand
  • 6 Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Sydney, NSW
  • 7 Sydney Children's Hospital, Randwick, Sydney, NSW
  • 8 University of Sydney, Sydney, NSW
  • 9 Menzies School of Health Research, Darwin, NT
  • 10 Australian Centre for Behavioural Research in Diabetes, Diabetes Victoria, Melbourne, VIC
  • 11 Deakin University, Geelong, VIC
  • 12 Royal Darwin Hospital, Darwin, NT
  • 13 Cairns Hospital, Cairns, QLD
  • 14 Diabetes Centre, Royal Prince Alfred Hospital, Sydney, NSW
  • 15 University of Queensland, Brisbane, QLD


Correspondence: alexia.pena@adelaide.edu.au

Acknowledgements: 

We thank the Australasian Paediatric Endocrine Group (APEG) for facilitating the creation of the guideline‐developing group, teleconference and meetings required for producing this manuscript. We also thank APEG, the New Zealand Society for the Study of Diabetes, and the Australian Diabetes Educators Association for reviewing and providing comments to the manuscript before endorsement.

Competing interests:

No relevant disclosures.

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Hospital in the home: needed now more than ever

Hugh G Dickson
Med J Aust 2020; 213 (1): . || doi: 10.5694/mja2.50662
Published online: 6 July 2020

Changes in models of care elicited by COVID‐19 may improve the quality of at‐home care for patients

As the coronavirus disease 2019 (COVID‐19) epidemic continues, attention in Australian hospitals has rapidly become more focused on methods for safely caring for patients while avoiding, when possible, admitting them to hospital or having them visit a hospital outpatient clinic. Diversion from hospitals reduces the risks for both patients and staff of cross‐infection or new infection with the COVID‐19 virus (SARS‐CoV‐2). Telehealth1 and hospital in the home2 (HITH) are two approaches for removing or reducing the need to attend a hospital while maintaining access to its clinical services. Neither system of care is novel, but each is experiencing a predictable surge in activity as the epidemic advances, and the two methods can be combined.


  • Livepool Hospital, South Western Sydney Local Health District, Sydney, NSW



Competing interests:

No relevant disclosures.

  • 1. Vimalananda VG, Orlander JD, Afable MK, et al. Electronic consultations (E‐consults) and their outcomes: a systematic review. J Am Med Infor Assoc 2020; 27: 471–479.
  • 2. Shepperd S, Iliffe S, Doll HA, et al. Admission avoidance hospital at home. Cochrane Database Syst Rev 2016; 9: CD007491.
  • 3. NSW Health. COVID‐19 (Coronavirus) statistics. 27 March 2020. https://www.health.nsw.gov.au/news/Pages/20200327_00.aspx (viewed Apr 2020).
  • 4. Montalto M, Leff B. “Hospital in the home”: a lot's in a name. Med J Aust 2012; 197: 479–480. https://www.mja.com.au/journal/2012/197/9/hospital-home-lots-name.
  • 5. Montalto M, McElduff P, Hardy K. Home ward bound: features of hospital in the home use by major Australian hospitals, 2011–2017. Med J Aust 2020; 213: 22–27.
  • 6. Scott IA. Public hospital bed crisis: too few or too misused? Aust Health Rev 2010; 34: 317–324.
  • 7. Varney J, Weiland TJ, Jelinek G. Efficacy of hospital in the home services providing care for patients admitted from emergency departments: an integrative review. Int J Evid Based Healthc 2014; 12: 128–141.

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Critically ill Indigenous Australians and mortality: a complex story

Paul J Secombe, Alex Brown, Michael J Bailey and David Pilcher
Med J Aust 2020; 213 (1): . || doi: 10.5694/mja2.50661
Published online: 6 July 2020

For most patients, life continues beyond the intensive care unit, and this is where action is needed

Aboriginal and Torres Strait Islander (Indigenous Australian) cultures thrived for thousands of years before European colonisation.1 The colonists brought disease, and displaced and marginalised the first peoples, the consequences of which are now seen as inequalities in life expectancy, social determinants of health, and interrupted access to health care.2 Indigenous people fare worse than non‐Indigenous Australians on a range of measures.3 They are over‐represented in acute hospital admissions, particularly to intensive care.4,5,6,7,8 In the critical care literature a consistent story emerges: critically ill Indigenous Australian patients are typically younger and more likely to be mechanically ventilated than non‐Indigenous patients, but their in‐hospital mortality, after adjusting for illness severity, is similar.

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  • 1 Alice Springs Hospital, Alice Springs, NT
  • 2 Flinders University, Adelaide, SA
  • 3 Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC
  • 4 South Australian Health and Medical Research Institute, Adelaide, SA
  • 5 University of South Australia, Adelaide, SA
  • 6 Centre for Outcome and Resource Evaluation, Australian and New Zealand Intensive Care Society, Melbourne, VIC
  • 7 The Alfred Hospital, Melbourne, VIC


Correspondence: paul.secombe@nt.gov.au

Acknowledgements: 

We acknowledge the wisdom and careful proof reading of Greg McAnulty.

Competing interests:

No relevant disclosures.

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Reducing stillbirth safely in Australia

Roshan Selvaratnam, Mary‐Ann Davey and Euan M Wallace
Med J Aust 2020; 213 (1): . || doi: 10.5694/mja2.50658
Published online: 22 June 2020

Caution is needed so that population‐level reductions in the stillbirth rate are not offset by iatrogenic harm to healthy babies

The federal Minister for Health the Honourable Greg Hunt MP recently launched the Safer Baby Bundle — a national stillbirth program that aims to reduce stillbirth in Australia by 20% by 2023.1 The program is one of the responses to recommendations arising from the federal Senate's Select Committee on Stillbirth Research and Education.2 It draws from similar bundles of care in the United Kingdom that have been associated with successful reductions in stillbirth.3,4 Undoubtedly, these whole‐of‐population level programs are important and effective. However, because late pregnancy stillbirth can be prevented simply by delivering all babies early, they have the potential for harm.


  • 1 Monash University, Melbourne, VIC
  • 2 Safer Care Victoria, Melbourne, VIC


Correspondence: euan.wallace@monash.edu

Acknowledgements: 

Euan Wallace is the recipient of a National Health and Medical Research Council (NHMRC) Program Grant (APP1113902). Roshan Selvaratnam has been granted a PhD Scholarship Top‐up from the NHMRC Stillbirth Centre of Research Excellence (APP1116640).

Competing interests:

No relevant disclosures.

  • 1. Centre of Research Excellence Stillbirth. Safer Baby Bundle handbook and resource guide: working together to reduce stillbirth. Stillbirth CRE, 2019. https://resources.stillbirthcre.org.au/downloads/SBB+Handbook_Final.pdf (viewed Nov 2019).
  • 2. Parliament of Australia. Select Committee on Stillbirth Research and Education report. Canberra: Commonwealth of Australia, 2018. https://www.aph.gov.au/Parliamentary_Business/Committees/Senate/Stillbirth_Research_and_Education/Stillbirth/Report (viewed Nov 2019).
  • 3. NHS England. Saving Babies’ Lives: a care bundle for reducing stillbirth. London: NHS England, 2016. https://www.england.nhs.uk/wp-content/uploads/2016/03/saving-babies-lives-car-bundl.pdf (viewed Nov 2019).
  • 4. Healthcare Improvement Scotland. Scottish Patient Safety Programme Maternity and Children, end of phase report. Edinburgh: HIS, 2016. https://ihub.scot/media/2317/spsp-mc-eopr.pdf (viewed Nov 2019).
  • 5. Selvaratnam RJ, Davey MA, Anil S, et al. Does public reporting of the detection of fetal growth restriction improve clinical outcomes: a retrospective cohort study. BJOG 2019; 127: 581–589.
  • 6. Monier I, Blondel B, Ego A, et al. Poor effectiveness of antenatal detection of fetal growth restriction and consequences for obstetric management and neonatal outcomes: a French national study. BJOG 2015; 122: 518–527.
  • 7. Bentley JP, Roberts CL, Bowen JR, et al. Planned birth before 39 weeks and child development: a population‐based study. Pediatrics 2016; 138: e20162002.
  • 8. Stacey T, Thompson JMD, Mitchell EA, et al. Maternal perception of fetal activity and late stillbirth risk: findings from the Auckland Stillbirth study. Birth 2011; 38: 311–316.
  • 9. Grant A, Valentin L, Elbourne D, Alexander S. Routine formal fetal movement counting and risk of antepartum late death in normally formed singletons. Lancet 1989; 334: 345–349.
  • 10. Norman JE, Heazell AEP, Rodriguez A, et al. Awareness of fetal movements and care package to reduce fetal mortality (AFFIRM): a stepped wedge, cluster‐randomised trial. Lancet 2018; 392: 1629–1638.
  • 11. Heazell AEP, Weir CJ, Stock SJE, et al. Can promoting awareness of fetal movements and focussing interventions reduce fetal mortality? A stepped‐wedge cluster randomised trial (AFFIRM) protocol. BMJ Open 2017; 7: e014813.
  • 12. Shah A. Using data for improvement. BMJ 2019; 364: l189.
  • 13. Sovio U, Goulding N, McBride N, et al. A maternal serum metabolite ratio predicts fetal growth restriction at term. Nature Med 2020; 26: 348–353.
  • 14. Bradford BF, Cronin RS, McCowan LME, et al. Association between maternally perceived quality and pattern of fetal movements and late stillbirth. Sci Rep 2019; 9: 9815.

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Opening the lines of communication: towards shared decision making and improved end‐of‐life care in the Top End

Emma Spencer and Eswaran Waran
Med J Aust 2020; 213 (1): . || doi: 10.5694/mja2.50656
Published online: 22 June 2020

Meeting the need for culturally appropriate discussions regarding patient values and preferences at end of life

Advance care directives are pre‐emptive discussions that anticipate a future loss of ability to make or communicate decisions. There is no uniformity in advance care directives in Australia, with each state or territory having differing terminologies and requirements.1 The Northern Territory has the lowest population density but the highest proportion of Aboriginal people of any Australian jurisdiction.2 In the NT, an individual can make a common law or statutory advance care directive,3 referred to as an advance personal plan (APP).4 The NT APP enables documentation of legally binding directives in reference to resuscitation and life support, as well as the appointment of substitute decision maker(s).5 We have previously documented the utility of the NT APP for Aboriginal people but highlighted the need for a more culturally appropriate document.6

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  • Royal Darwin Hospital, Darwin, NT


Correspondence: emma.spencer@nt.gov.au

Acknowledgements: 

We thank the TEHS GOC committee and the Barwon Health/Deakin University iValidate Communications Training Team.

Competing interests:

No relevant disclosures.

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The deleterious effects of cannabis during pregnancy on neonatal outcomes

Luke E Grzeskowiak, Jessica A Grieger, Prabha Andraweera, Emma J Knight, Shalem Leemaqz, Lucilla Poston, Lesley McCowan, Louise Kenny, Jenny Myers, James J Walker, Gustaaf A Dekker and Claire T Roberts
Med J Aust 2020; 212 (11): . || doi: 10.5694/mja2.50624
Published online: 15 June 2020

Abstract

Objectives: To evaluate whether cannabis use during pregnancy is associated with adverse neonatal outcomes that are independent of cigarette smoking.

Design: Prospective cohort study.

Setting: Adelaide (Australia), Auckland (New Zealand), Cork (Ireland), and Leeds, London and Manchester (United Kingdom).

Participants: 5610 pregnant nulliparous women with low risk pregnancies recruited for the Screening for Pregnancy Endpoints (SCOPE) study, November 2004 – February 2011. At 14–16 weeks of pregnancy, women were grouped by self‐reported cannabis use.

Main outcome measures: Infant birthweight, head circumference, birth length, gestational age, and severe neonatal morbidity or mortality.

Results: 314 women (5.6%) reported using cannabis in the 3 months before or during their pregnancy; 97 (31%) stopped using it before and 157 (50%) during the first 15 weeks of pregnancy, while 60 (19%) were still using cannabis at 15 weeks. Compared with babies of mother who had never used cannabis, infants of those who still used it at 15 weeks had lower mean values for birthweight (adjusted mean difference [aMD], –127 g; 95% CI, –238 to –17 g), head circumference (aMD, –0.5 cm; 95% CI, –0.8 to –0.1 cm), birth length (aMD, –0.8 cm; 95% CI, –1.4 to –0.2 cm), and gestational age at birth (aMD, –8.1 days; 95% CI, –12.1 to –4.0 days). The differences for all outcomes except gestational age were greater for women who used cannabis more than once a week than for those who used it less frequently.

Conclusions: Continuing to use cannabis during pregnancy is an independent risk factor for poorer neonatal outcomes.

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  • 1 Robinson Research Institute, University of Adelaide, Adelaide, SA
  • 2 Adelaide Medical School, University of Adelaide, Adelaide, SA
  • 3 Women's Health Academic Centre and King's Health Partners, King's College London, London, United Kingdom
  • 4 Auckland University, Auckland, New Zealand
  • 5 University of Liverpool, Liverpool, United Kingdom
  • 6 Maternal and Fetal Health Research Centre, University of Manchester, Manchester, United Kingdom
  • 7 Institute of Biomedical and Clinical Sciences, University of Leeds, Leeds, United Kingdom



Acknowledgements: 

We thank all SCOPE participants and the SCOPE research midwives in each centre. The SCOPE database is provided and maintained by MedSciNet (medscinet.com). The Australian SCOPE study was funded by the Premier's Science and Research Fund (South Australian government). The New Zealand SCOPE study was funded by the New Enterprise Research Fund, the Foundation for Research Science and Technology, the Health Research Council (04/198), the Evelyn Bond Trust, and the Auckland District Health Board Charitable Trust. The Irish SCOPE study was funded by the Health Research Board of Ireland (CSA/2007/2). The United Kingdom SCOPE study was funded by a National Health Service NEAT grant (FSD025), the Biotechnology and Biological Sciences Research Council (GT084), University of Manchester Proof of Concept Funding, and the Guy's and St. Thomas’ Charity (King's College London), Tommy's Charity (King's College London and University of Manchester), and Cerebra UK (University of Leeds). Claire Roberts was supported by a National Health and Medical Research Council (NHMRC) Senior Research Fellowship (GNT1020749) and a Lloyd Cox Professorial Fellowship (University of Adelaide). Luke Grzeskowiak was supported by an NHMRC Early Career Fellowship (GNT1070421), a Robinson Research Institute Career Development Fellowship, and a Lloyd Cox Research Fellowship (University of Adelaide).

Competing interests:

No relevant disclosures.

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Will online symptom checkers improve health care in Australia?

Adam G Dunn
Med J Aust 2020; 212 (11): . || doi: 10.5694/mja2.50621
Published online: 15 June 2020

The available tools are largely unregulated, and do not reliably guide people to the right care at the right time

In times when health services are under increasing strain, digital health technologies such as online symptom checkers appear convenient and cost‐effective tools for reducing the burden on clinics, telemedicine services, and emergency departments. In practical terms, an online symptom checker is a smartphone app or web‐based form that can provide a diagnosis on the basis of a set of self‐reported symptoms. They can suggest diagnoses for a broad range of conditions with which people may present to a clinic or emergency department. When they work properly, symptom checkers should turn current practice guidelines into tools that can diagnose and triage patients at low cost.


  • The University of Sydney, Sydney, NSW


Correspondence: adam.dunn@sydney.edu.au

Competing interests:

No relevant disclosures.

  • 1. Hill MG, Sim M, Mills B. The quality of diagnosis and triage advice provided by free online symptom checkers and apps in Australia. Med J Aust 2020; 213: 514–519.
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  • 5. Meyer AND, Giardina TD, Spitzmueller C, et al. Patient perspectives on the usefulness of an artificial intelligence–assisted symptom checker: cross‐sectional survey study. J Med Internet Res 2020; 22: e14679.
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  • 10. Winn AN, Somai M, Fergestrom N, Crotty BH. Associations of use of online symptom checkers with patients’ plans for seeking care. JAMA Network Open 2019; 2: e1918561.

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The vitamin D testing rate is again rising, despite new MBS testing criteria

Louisa Gordon, Mary Waterhouse, Ian R Reid and Rachel E Neale
Med J Aust 2020; 213 (4): . || doi: 10.5694/mja2.50619
Published online: 8 June 2020

The number of tests for vitamin D deficiency in Australia rose steeply between 2000 and 2011, from 0.4 to 36.5 tests per 1000 population; the cost to Medicare increased from $1.1 million in 2000 to $95.6 million in 2010,1 and peaked at $151 million in 2012–13.2 Consequently, the Medical Benefits Schedule (MBS) items for testing (66608, 66609) were replaced in November 2014 by new items (66833–66837) with the aim of restricting testing to people at particular risk of vitamin D deficiency, including those with a history of osteomalacia or osteoporosis, elevated alkaline phosphatase levels, hyperparathyroidism, hypo‐ or hypercalcaemia, hypophosphataemia, malabsorption, chronic renal failure, deeply pigmented skin or chronic and severe lack of sun exposure, or a diagnosis of vitamin D deficiency, and people who used medications that reduce 25‐hydroxyvitamin D levels.3


  • 1 QIMR Berghofer Medical Research Institute, Brisbane, QLD
  • 2 Queensland University of Technology (QUT), Brisbane, QLD
  • 3 The University of Auckland, Auckland, New Zealand
  • 4 The University of Queensland, Brisbane, QLD



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No relevant disclosures.

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Assessing angiotensin‐converting enzyme (ACE) protein is more appropriate than ACE activity when investigating sarcoidosis

Carel J Pretorius and Jacobus PJ Ungerer
Med J Aust 2020; 213 (4): . || doi: 10.5694/mja2.50620
Published online: 8 June 2020

Elevated serum angiotensin‐converting enzyme (ACE) activity, a biomarker for epithelioid granuloma, has a supportive role in the diagnosis and management of sarcoidosis,1 although in population‐based studies its diagnostic usefulness is modest, with positive and negative predictive values of 25.4% and 89.9% respectively.2 Further, elevated ACE activity is non‐specific; it is also found in people with tuberculous and other infectious granulomata, liver disease, lymphoma, diabetes, or hyperthyroidism, and also as a benign familial condition. However, elevated ACE activity can facilitate some clinical decisions, including the diagnosis of Löfgren syndrome or adults with uveitis.1,3

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  • Pathology Queensland, Brisbane, QLD



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No relevant disclosures.

  • 1. Ahmadzai H, Huang S, Steinfort C, et al. Sarcoidosis: a state of the art review from the Thoracic Society of Australia and New Zealand. Med J Aust 2018; 208: 499–504. https://www.mja.com.au/journ​al/2018/208/11/sarco​idosis-state-art-review-thora​cic-socie​ty-austr​alia-and-new-zealand.
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  • 6. Singh H, Spitzmueller C, Petersen NJ, et al. Information overload and missed test results in electronic health record‐based settings. JAMA Intern Med 2013; 173: 702–703.

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Australian residential aged care is understaffed

Kathy Eagar, Anita Westera and Conrad Kobel
Med J Aust 2020; 212 (11): . || doi: 10.5694/mja2.50615
Published online: 1 June 2020

The existing system is failing to deliver the care that Australia expects

Australia's aged care has changed considerably in recent decades. In response to consumer demand, old institutional‐style nursing homes have been progressively phased out in favour of better facilities. Home‐like furnishings and decor and single bedrooms personalised with residents’ own belongings have increasingly become the norm. In the process, they have become residential aged care facilities (RACFs), and there is no longer a distinction between low and high care.1


  • Australian Health Services Research Institute, University of Wollongong, Wollongong, NSW


Correspondence: keagar@uow.edu.au

Acknowledgements: 

The research summarised in this article was funded by the Royal Commission into Aged Care Quality and Safety. This funding was paid to the university and not the authors. The Royal Commission into Aged Care Quality and Safety had no role in the research or in the preparation of the manuscript.

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None declared.

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