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Symptoms of depression and anxiety during the COVID‐19 pandemic: implications for mental health

Helen Herrman and Christian Kieling
Med J Aust 2021; 214 (10): . || doi: 10.5694/mja2.51080
Published online: 7 June 2021

People with existing mental health problems or living in difficult circumstances may be at particular risk

The short and longer term adverse effects of the coronavirus disease 2019 (COVID‐19) pandemic and its economic consequences on the mental health of individuals and communities are under intense scrutiny.1,2 Governments and scientists are anxious about the adequacy of mental health services and the possibility of increased suicide rates.3,4

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  • 1 Orygen, Melbourne, VIC
  • 2 Centre for Youth Mental Health, the University of Melbourne, Melbourne, VIC
  • 3 Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
  • 4 Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil


Correspondence: h.herrman@unimelb.edu.au

Competing interests:

No relevant disclosures.

  • 1. United Nations COVID‐19 and the need for action on mental health [policy brief]. May 2020. https://unsdg.un.org/sites/default/files/2020-05/UN-Policy-Brief-COVID-19-and-mental-health.pdf (viewed Apr 2021).
  • 2. Pfefferbaum B, North CS. Mental health and the Covid‐19 pandemic. N Engl J Med 2020; 383: 510–512.
  • 3. Atkinson JA, Skinner A, Lawson K, et al; Brain and Mind Centre, University of Sydney. Road to recovery: restoring Australia’s mental wealth. 27 July 2020 https://www.sydney.edu.au/content/dam/corporate/documents/brain-and-mind-centre/youthe/road-to-recovery-v2.pdf (viewed Mar 2021).
  • 4. Tanaka T, Okamoto S. Increase in suicide following an initial decline during the COVID‐19 pandemic in Japan. Nat Hum Behav 2021; 5: 229–238.
  • 5. Prati G, Mancini AD. The psychological impact of COVID‐19 pandemic lockdowns: a review and meta‐analysis of longitudinal studies and natural experiments. Psychol Med 2021; 51: 201–211.
  • 6. Robinson E, Sutin AR, Daly M, Jones A. A systematic review and meta‐analysis of longitudinal cohort studies comparing mental health before versus during the COVID‐19 pandemic [preprint]. medRxiv 8 Mar 2021; https://doi.org/10.1101/2021.03.04.21252921 (viewed Mar 2021).
  • 7. Beyond Blue. Bushfires and mental health [web page]. 2020. https://www.beyondblue.org.au/the-facts/bushfires-and-mental-health (viewed Mar 2021).
  • 8. Batterham PJ, Calear AL, McCallum SM, et al. Trajectories of depression and anxiety symptoms during the COVID‐19 pandemic in a representative Australian adult cohort. Med J Aust 2021; 214: 462–468.
  • 9. Daly M, Sutin AR, Robinson E. Longitudinal changes in mental health and the COVID‐19 pandemic: evidence from the UK Household Longitudinal Study. Psychol Med 2020; 13: 1–10.
  • 10. Pan KY, Kok AAL, Eikelenboom M, et al. The mental health impact of the COVID‐19 pandemic on people with and without depressive, anxiety, or obsessive‐compulsive disorders: a longitudinal study of three Dutch case–control cohorts. Lancet Psychiatry 2021; 8: 121–129.
  • 11. Patel V, Burns JK, Dhingra M, et al. Income inequality and depression: a systematic review and meta‐analysis of the association and a scoping review of mechanisms. World Psychiatry 2018; 17: 76–89.
  • 12. Courtin E, Knapp M. Social isolation, loneliness and health in old age: a scoping review. Health Soc Care Community 2017; 25: 799–812.
  • 13. Herrman H, Stewart DE, Diaz‐Granados N, et al. What is resilience? Can J Psychiatry 2011; 56: 258–265.
  • 14. Australian Department of Health. What we’re doing about suicide prevention. Updated 19 Apr 2021. https://www.health.gov.au/health-topics/mental-health-and-suicide-prevention/what-were-doing-about-suicide-prevention#strategies-and-plans (viewed Apr 2021).
  • 15. Leucht S, Cipriani A, Furukawa TA, et al. A living meta‐ecological study of the consequences of the COVID‐19 pandemic on mental health. Eur Arch Psychiatry Clin Neurosci 2021; 271: 219–221.
  • 16. Novins DK, Stoddard J, Althoff RR, et al. Research priorities in child and adolescent mental health emerging from the COVID‐19 pandemic. J Am Acad Child Adolesc Psychiatry 2021; 17: S0890–8567(21)00153–2 [online ahead of print.].

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Improving recruitment to clinical trials for regional and rural cancer patients through a regionally based clinical trials network

Arun Muthusamy, Donna Long and Craig R Underhill
Med J Aust 2021; 214 (10): . || doi: 10.5694/mja2.51078
Published online: 7 June 2021

A new clinical trials network aims to bridge the gap in cancer outcomes between rural and metropolitan cancer patients in Victoria

In general, regional and rural patients have poorer cancer outcomes compared with their city counterparts.1 Although one‐third of the Australian population live in rural and regional areas, there is ongoing inequity in access to care among regional Australians.2 Over the decade to 2010, the disparity in cancer outcomes between rural and urban patients remained unchanged with 7% excess mortality (equating to about 9000 additional rural deaths).3,4 Until recently, clinical trials were almost exclusively conducted in metropolitan health institutions. Although a gateway to new treatments that can result in improved survival, clinical trials may be out of reach for many regional and rural cancer patients owing to distance.2,5,6,7,8,9,10 In 2016, the rate of cancer trial participation was 6.7% in metropolitan Melbourne, but only 1.2% in regional Victoria.4 In that year, a total of 443 patients from regional Victoria accessed clinical cancer trials, but 343 of those regional patients travelled to Melbourne to access a trial.4 We postulate that low rates of trial participation may be a contributing factor to lower cancer 5‐year survival in regional Victoria (66% compared with 70% in metropolitan Melbourne).4


  • 1 Border Medical Oncology, Albury, NSW
  • 2 Regional Trials Network Victoria, Albury, NSW
  • 3 Rural Clinical School, UNSW, Albury, NSW



Acknowledgements: 

The authors and the RTNV thank the Victorian Cancer Council and Victorian Cancer Agency for funding this project. The funding sources played no part in the planning, writing or publication of the work. We also acknowledge and thank colleagues from the RTNV sites, Cancer Trials Australia and others who contributed to this project, VCCC colleagues for collaboration on the teletrials component, and the patients and their carers who gave their consent to enrol in a clinical trial.

Competing interests:

Donna Long is employed under the grant from the funders acknowledged above.

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Artificial intelligence and medical imaging: applications, challenges and solutions

Meng Law, Jarrel Seah and George Shih
Med J Aust 2021; 214 (10): . || doi: 10.5694/mja2.51077
Published online: 7 June 2021

AI‐based tools can help with image acquisition, reconstruction and quality; interpretation, diagnosis and decision support; and manual tasks

Artificial intelligence (AI) is having a disruptive impact in many areas, including health care. In medicine, machine learning (ML) techniques have existed for decades but were mostly not adopted. New deep learning techniques, along with copious medical imaging and digital health data, now provide standardised, reproducible, dependable and accurate diagnostic reports. These can only improve patient care and safety, enhancing the practice of clinical medicine. However, a number of challenges have arisen, hindering progress and more widespread application. In this article, we describe current AI/ML tools in medical imaging, discuss the major challenges facing the field, and offer some potential solutions.


  • 1 Alfred Health, Melbourne, VIC
  • 2 Monash University, Melbourne, VIC
  • 3 Alfred Hospital, Melbourne, VIC
  • 4 Weill Cornell Medicine, New York, NY, USA


Correspondence: meng.law@alfred.org.au

Competing interests:

No relevant disclosures.

  • 1. Elshafeey N, Kotrotsou A, Hassan A, et al. Multicenter study demonstrates radiomic features derived from magnetic resonance perfusion images identify pseudoprogression in glioblastoma. Nat Commun 2019; 10: 3170.
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National Heart Foundation of Australia: position statement on coronary artery calcium scoring for the primary prevention of cardiovascular disease in Australia

Garry LR Jennings, Ralph Audehm, Warrick Bishop, Clara K Chow, Siaw-Teng Liaw, Danny Liew and Sara M Linton
Med J Aust 2021; 214 (9): . || doi: 10.5694/mja2.51039
Published online: 17 May 2021

Abstract

Introduction: This position statement considers the evolving evidence on the use of coronary artery calcium scoring (CAC) for defining cardiovascular risk in the context of Australian practice and provides advice to health professionals regarding the use of CAC scoring in primary prevention of cardiovascular disease in Australia.

Main recommendations:

  • CAC scoring could be considered for selected people with moderate absolute cardiovascular risk, as assessed by the National Vascular Disease Prevention Alliance (NVDPA) absolute cardiovascular risk algorithm, and for whom the findings are likely to influence the intensity of risk management. (GRADE evidence certainty: Low. GRADE recommendation strength: Conditional.)
  • CAC scoring could be considered for selected people with low absolute cardiovascular risk, as assessed by the NVDPA absolute cardiovascular risk algorithm, and who have additional risk-enhancing factors that may result in the underestimation of risk. (GRADE evidence certainty: Low. GRADE recommendation strength: Conditional.)
  • If CAC scoring is undertaken, a CAC score of 0 AU could reclassify a person to a low absolute cardiovascular risk status, with subsequent management to be informed by patient–clinician discussion and follow contemporary recommendations for low absolute cardiovascular risk. (GRADE evidence certainty: Very low. GRADE recommendation strength: Conditional.)
  • If CAC scoring is undertaken, a CAC score > 99 AU or ≥ 75th percentile for age and sex could reclassify a person to a high absolute cardiovascular risk status, with subsequent management to be informed by patient–clinician discussion and follow contemporary recommendations for high absolute cardiovascular risk. (GRADE evidence certainty: Very low. GRADE recommendation strength: Conditional.)

Changes in management as a result of this statement: CAC scoring can have a role in reclassification of absolute cardiovascular risk for selected patients in Australia, in conjunction with traditional absolute risk assessment and as part of a shared decision‐making approach that considers the preferences and values of individual patients.

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  • 1 University of Sydney, Sydney, NSW
  • 2 National Heart Foundation of Australia, Melbourne, VIC
  • 3 General Practice and Primary Health Care Academic Centre, University of Melbourne, Melbourne, VIC
  • 4 Calvary Health Care Tasmania Lenah Valley Campus, Hobart, TAS
  • 5 Westmead Hospital, Sydney, NSW
  • 6 UNSW Sydney, Sydney, NSW
  • 7 Ingham Institute of Applied Medical Research, Sydney, NSW
  • 8 Monash University, Melbourne, VIC
  • 9 Royal Melbourne Hospital, Melbourne, VIC



Acknowledgements: 

Funding and coordination were provided by the National Heart Foundation of Australia. Expert reference group members contributed to the technical content on an advisory basis. The position statement manuscript and GRADE evidence appraisal were prepared by the National Heart Foundation of Australia.

Competing interests:

Warrick Bishop receives consultancy fees to report on coronary artery calcium scoring test results, and has written a book on the subject. He is paid membership fees for his website, which provides information about heart attack prevention. Clara Chow receives consultancy fees to report on coronary artery calcium scoring test results. Danny Liew receives honoraria to conduct cost‐effective analyses for pharmaceutical companies.

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Lessons from the United Kingdom’s COVID‐19 vaccination strategy

Anthony Harnden and Andrew Earnshaw
Med J Aust 2021; 214 (9): . || doi: 10.5694/mja2.51042
Published online: 17 May 2021

The predominantly age‐based structure of the British vaccination program has enabled a rapid delivery with high vaccine uptake

The United Kingdom has been profoundly affected by the coronavirus disease 2019 (COVID‐19) pandemic. In our population of over 66 million, to date we have had over 4.3 million confirmed infections with over 127 000 deaths (10 April 2021).1 Vaccination has provided an opportunity to limit the impact of COVID‐19 on our population and hopefully reduce the risk of significant mortality in any third wave.

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  • 1 University of Oxford, Oxford, UK
  • 2 United Kingdom Joint Committee on Vaccination and Immunisation, National Immunization Technical Advisory Groups, London, UK



Competing interests:

Anthony Harnden is Deputy Chair and Andrew Earnshaw is Head of the UK Joint Committee on Vaccination and Immunisation.

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The challenges of managing both chronic pain and opioid use in general practice

Hester Wilson
Med J Aust 2021; 214 (9): . || doi: 10.5694/mja2.51041
Published online: 17 May 2021

The safety and value of reducing opioid use are recognised, but difficult conversations and less accessible alternatives are barriers

Chronic pain affects about 20% of adults in Australia and New Zealand,1,2 and opioids have been enthusiastically embraced for treating it. Unfortunately, this has led to significant harm,3,4,5 and evidence of the long term effectiveness of opioids for relieving chronic pain is limited.3,6


  • 1 The Langton Centre, Sydney, NSW
  • 2 University of New South Wales, Sydney, NSW
  • 3 Alice St General Practice, Sydney, NSW



Competing interests:

I have no connections with the tobacco, alcohol or gaming industries. I have received funding for consultancies or for serving on expert advisory panels from Indivior, Lundbeck, Seqirus, Mundipharma, and Pfizer.

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Introducing general practice enrolment in Australia: the devil is in the detail

Michael Wright and Roald Versteeg
Med J Aust 2021; 214 (9): . || doi: 10.5694/mja2.51027
Published online: 17 May 2021

Enrolment may strengthen the link between patients and their preferred primary care providers and needs to support flexible provision of high quality care

In the 2019–20 federal budget, $448 million was allocated to introduce a system of voluntary general practice enrolment for Indigenous people over 50 years of age and all Australians over 70 years of age from July 2020.1 Enrolment, also known as nomination or empanelment, allows patients to register with a specified general practitioner at their preferred general practice. At the end of June 2020, the federal government announced that the introduction of voluntary general practice enrolment would be delayed and that models to support universal enrolment would be explored as part of the development of a 10‐year primary health care plan.2 The exploration of population‐wide enrolment was prompted by Australia’s coronavirus disease 2019 (COVID‐19) response, most notably the introduction of Medicare‐funded telehealth (both telephone and video consultations) — a long‐advocated reform currently available until 30 June 2021. In this article, we outline Australian and international experience with enrolment and suggest ways for Australia to introduce a system that benefits patients, health system funders and providers of comprehensive holistic general practice care.


  • 1 Centre for Health Economics Research and Evaluation, University of Technology, Sydney, NSW
  • 2 Royal Australian College of General Practitioners, Melbourne, VIC



Competing interests:

Michael Wright chairs the Royal Australian College of General Practitioners (RACGP) Expert Committee on Funding and Health System Reform, chairs the Board of the Central and Eastern Sydney Primary Health Network, was a member of the Primary Health Care Advisory Group and has advisory roles with the Australian Institute of Health and Welfare. Roald Versteeg is employed by the RACGP.

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  • 3. Wright M, Hall J, van Gool K, et al. How common is multiple general practice attendance? Aust J Gen Pract 2018; 47: 289–296.
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  • 5. Medicare Benefits Schedule Review Taskforce. Taskforce findings: General Practice and Primary Care Clinical Committee Report. Canberra: Commonwealth of Australia, 2020. https://www.health.gov.au/resources/publications/taskforce-findings-general-practice-and-primary-care-clinical-committee-report (viewed Apr 2021).
  • 6. Australian Government Department of Health. Evaluation report of the Diabetes Care Project. Canberra: Commonwealth of Australia, 2015. https://www.health.gov.au/sites/default/files/documents/2019/09/evaluation-of-the-diabetes-care-project-evaluation-report-of-the-diabetes-care-project.pdf (viewed Apr 2021).
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  • 8. Kalucy L, Katterl R, Jackson‐Bowers E, et al. Models of patient enrolment (PHC RIS Policy Issue Review). Adelaide: Primary Health Care Research and Information Service, 2009. https://dspace2.flinders.edu.au/xmlui/bitstream/handle/2328/26593/PIR%20May%2009.pdf?sequence=1&isAllowed=y (viewed Mar 2021).
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  • 10. van Walraven C, Oake N, Jennings A, Forster AJ. The association between continuity of care and outcomes: a systematic and critical review. J Eval Clin Pract 2010; 16: 947–956.
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  • 23. Tammes P, Payne RA, Salisbury C, et al. The impact of a named GP scheme on continuity of care and emergency hospital admission: a cohort study among older patients in England, 2012–2016. BMJ Open 2019; 9: e029103.

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Health for all by 2030 is within our grasp: we must act now

Sandro Demaio
Med J Aust 2021; 214 (8): . || doi: 10.5694/mja2.51018
Published online: 3 May 2021

Australia has a once‐in‐a-lifetime opportunity to create a healthy, sustainable, equitable and prosperous future by taking bold action to build back better, fairer and greener after the coronavirus pandemic

Australia is considered a coronavirus disease 2019 (COVID‐19) success story by international standards,1 notwithstanding the significant health and economic impacts experienced across the country. The level of pandemic‐induced disruption has been profound, with COVID‐19 catapulting us all, as individuals and communities, into new ways of being.

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  • 1 Victorian Health Promotion Foundation, Melbourne
  • 2 University of Melbourne, Melbourne



Competing interests:

No relevant disclosures.

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The increasing burden of inflammatory bowel disease

Edward V Loftus
Med J Aust 2021; 214 (8): . || doi: 10.5694/mja2.51001
Published online: 3 May 2021

Until we reach “prevalence equilibrium”, even small increases in incidence eventually result in higher prevalence

When I attended medical school in the 1980s, we were taught that ulcerative colitis and Crohn disease were conditions seen in white people in highly developed regions such as northern Europe, the United Kingdom and some Commonwealth nations, and North America. Over the past four decades, the incidence of inflammatory bowel disease (IBD) across geographic regions and ethnic groups has risen sharply.1 The global burden of IBD, which can substantially reduce quality of life, is clearly increasing.2 Patients with IBD often require expensive medications or procedures,3 have higher rates of anxiety and depression,4 and are more likely to have disabilities.5


  • Mayo Clinic, Rochester, MN, United States of America


Correspondence: loftus.edward@mayo.edu

Competing interests:

I have provided consultation services to AbbVie, Amgen, Allergan, Boehringer Ingelheim, Bristol‐Myers Squibb, Celgene, Celltrion Healthcare, Eli Lilly, Genentech, Gilead, Iterative Scopes, Janssen, Ono Pharma, Pfizer, Takeda, and UCB. I have received research support from AbbVie, Amgen, Bristol‐Myers Squibb, Celgene, Genentech, Gilead, Janssen, Pfizer, Receptos, Robarts Clinical Trials, Takeda, and UCB. I am a shareholder in Exact Sciences.

  • 1. Ng SC, Shi HY, Hamidi N, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet 2017; 390: 2769–2778.
  • 2. GBD 2017 Inflammatory Bowel Disease Collaborators. The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol Hepatol 2020; 5: 17-30.
  • 3. Park KT, Ehrlich OG, Allen JI, et al. The cost of inflammatory bowel disease: an initiative from the Crohn’s & Colitis Foundation. Inflamm Bowel Dis 2020; 26: 1–10.
  • 4. Szigethy EM, Allen JI, Reiss M, et al. White paper AGA: the impact of mental and psychosocial factors on the care of patients with inflammatory bowel disease. Clin Gastroenterol Hepatol 2017; 15: 986–997.
  • 5. Lo B, Prosberg MV, Gluud LL, et al. Systematic review and meta-analysis: assessment of factors affecting disability in inflammatory bowel disease and the reliability of the inflammatory bowel disease disability index. Aliment Pharmacol Ther 2018; 47: 6–15.
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  • 7. Shivashankar R, Tremaine WJ, Harmsen WS, Loftus EV. Incidence and prevalence of Crohn’s disease and ulcerative colitis in Olmsted County, Minnesota from 1970 through 2010. Clin Gastroenterol Hepatol 2017; 15: 857–863.
  • 8. Aniwan S, Harmsen WS, Tremaine WJ, et al. Overall and cause-specific mortality of inflammatory bowel disease in Olmsted County, Minnesota, from 1970 through 2016. Mayo Clin Proc 2018; 93: 1415–1422.
  • 9. Kaplan GG. The global burden of IBD: from 2015 to 2025. Nat Rev Gastroenterol Hepatol 2015; 12: 720–727.
  • 10. Kaplan GG, Bernstein CN, Coward S, et al. The impact of inflammatory bowel disease in Canada 2018: epidemiology. J Can Assoc Gastroenterol 2019; 2(Suppl 1): S6–S16.
  • 11. Jones GR, Lyons M, Plevris N, et al. IBD prevalence in Lothian, Scotland, derived by capture-recapture methodology. Gut 2019; 68: 1953–1960.
  • 12. Pudipeddi A, Liu J, Kariyawasam V, et al. High prevalence of Crohn disease and ulcerative colitis among older people in Sydney. Med J Aust 2021; 214: 365–370.
  • 13. Mahid SS, Minor KS, Soto RE, et al. Smoking and inflammatory bowel disease: a meta-analysis. Mayo Clin Proc 2006; 81: 1462–1471.
  • 14. Peppercorn MA. The overlap of inflammatory bowel disease and diverticular disease. J Clin Gastroenterol 2004; 38(Suppl 1): S8–S10.
  • 15. Thia KT, Loftus EV, Sandborn WJ, Yang SK. An update on the epidemiology of inflammatory bowel disease in Asia. Am J Gastroenterol 2008; 103: 3167–3182.
  • 16. Ng SC, Tang W, Ching JY, et al. Incidence and phenotype of inflammatory bowel disease based on results from the Asia-Pacific Crohn’s and Colitis Epidemiology Study. Gastroenterology 2013; 145: 158–165.
  • 17. Charpentier C, Salleron J, Savoye G, et al. Natural history of elderly-onset of inflammatory bowel disease: a population-based cohort study. Gut 2014; 63: 423–432.
  • 18. Piovani D, Danese S, Peyrin-Biroulet L, et al. Systematic review with meta-analysis: biologics and risk of infection or cancer in elderly patients with inflammatory bowel disease. Aliment Pharmacol Ther 2020; 51: 820–830.
  • 19. Nguyen GC, Targownik LE, Singh H, et al. The impact of inflammatory bowel disease in Canada 2018: IBD in seniors. J Can Assoc Gastroenterol 2109; 2(Suppl 1): S68-S72.
  • 20. Kochar B, Cai W, Cagan A, Ananthakrishnan AN. Pretreatment frailty is independently associated with increased risk of infections after immunosuppression in patients with inflammatory bowel diseases. Gastroenterology 2020; 158: 2104–2111.
  • 21. Qian AS, Nguyen NH, Elia J, et al. Frailty is independently associated with mortality and readmission in hospitalized patients with inflammatory bowel diseases. Clin Gastroenterol Hepatol 2020; https://doi.org/10.1016/j.cgh.2020.08.010 [online ahead of print].
  • 22. Kaplan GG, Windsor JW. The four epidemiological stages of the global evolution of inflammatory bowel disease. Nat Rev Gastroenterol Hepatol 2021; 18: 56–66.

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Lack of efficacy of cannabidiol for relieving back pain: time to re‐set expectations?

Chris Hayes and Jennifer H Martin
Med J Aust 2021; 214 (8): . || doi: 10.5694/mja2.51025
Published online: 3 May 2021

In the absence of evidence of benefit for acute low back pain, its over‐the‐counter availability should be reconsidered

Decades of opioid overuse can teach us valuable lessons about how we should handle medicinal cannabinoids, including cannabidiol (CBD). One major lesson is that access to medicines should not move ahead of scientific evidence. Over time, evidence that context is critical has accumulated: using opioids to treat acute pain and cancer pain, in the management of opioid dependency, and in palliative care can be justified. However, the indication creep from acute to chronic non‐cancer pain was unwarranted. Consequently, clinicians are sensitive to new pain medicines being made available without evidence of benefit, and the motivations for accelerated access have been questioned.1


  • 1 Hunter Integrated Pain Service, Hunter New England Local Health Districts, Newcastle, NSW
  • 2 Centre for Drug Repuposing and Medicines Research, University of Newcastle, Newcastle, NSW



Competing interests:

Jennifer Martin has a relative who is the chief medical officer of CannaPacific, a company licensed to grow cannabis; she herself has no financial or administrative involvement with the company.

  • 1. Bell RF, Kalso EA. Cannabinoids for pain or profit? Pain 2020; https://doi.org/10.1097/j.pain.0000000000001930 [online ahead of print].
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  • 4. Stockings E, Campbell G, Hall W, et al. Cannabis and cannabinoids for the treatment of people with chronic noncancer pain conditions: a systematic review and meta‐analysis of controlled and observational studies. Pain 2018; 159: 1932–1954.
  • 5. McCartney D, Benson MJ, Desbrow B, et al. Cannabidiol and sports performance: a narrative review of relevant evidence and recommendations for future research. Sports Med Open 2020; 6: 27.
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  • 10. Therapeutic Goods Administration. Over-the‐counter access to low dose cannabidiol [media release]. 15 Dec 2020. https://www.tga.gov.au/media-release/over-counter-access-low-dose-cannabidiol (viewed Mar 2021).
  • 11. Millar SA, Stone NL, Bellman ZD, et al. A systematic review of cannabidiol dosing in clinical populations. Br J Clin Pharmacol 2019; 85: 1888–1900.
  • 12. Kocis PT, Vrana KE. Delta‐9-tetrahydrocannabinol and cannabidiol drug–drug interactions. Med Cannabis Cannabinoids 2020; 3: 61–73.
  • 13. Bebee B, Taylor DM, Bourke E, et al. The CANBACK trial: a randomised, controlled clinical trial of oral cannabidiol for people presenting to the emergency department with acute low back pain. Med J Aust 2021; 214: 370–375.
  • 14. Manini AF, Yiannoulos G, Bergamaschi MM, et al. Safety and pharmacokinetics of oral cannabidiol when administered concomitantly with intravenous fentanyl in humans. J Addict Med 2015; 9: 204–210.

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