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The 2021 report of the MJALancet Countdown on health and climate change: Australia increasingly out on a limb

Paul J Beggs, Ying Zhang, Alice McGushin, Stefan Trueck, Martina K Linnenluecke, Hilary Bambrick, Helen L Berry, Ollie Jay, Lucie Rychetnik, Ivan C Hanigan, Geoffrey G Morgan, Yuming Guo, Arunima Malik, Mark Stevenson, Donna Green, Fay H Johnston, Celia McMichael, Ian Hamilton and Anthony G Capon
Med J Aust 2021; 215 (9): . || doi: 10.5694/mja2.51302
Published online: 21 October 2021

Summary

  • The MJALancet Countdown on health and climate change in Australia was established in 2017, and produced its first national assessment in 2018, its first annual update in 2019, and its second annual update in 2020. It examines indicators across five broad domains: climate change impacts, exposures and vulnerability; adaptation, planning and resilience for health; mitigation actions and health co‐benefits; economics and finance; and public and political engagement.
  • Our special report in 2020 focused on the unprecedented and catastrophic 2019–20 Australian bushfire season, highlighting indicators that explore the relationships between health, climate change and bushfires. For 2021, we return to reporting on the full suite of indicators across each of the five domains and have added some new indicators.
  • We find that Australians are increasingly exposed to and vulnerable to excess heat and that this is already limiting our way of life, increasing the risk of heat stress during outdoor sports, and decreasing work productivity across a range of sectors. Other weather extremes are also on the rise, resulting in escalating social, economic and health impacts. Climate change disproportionately threatens Indigenous Australians’ wellbeing in multiple and complex ways.
  • In response to these threats, we find positive action at the individual, local, state and territory levels, with growing uptake of rooftop solar and electric vehicles, and the beginnings of appropriate adaptation planning. However, this is severely undermined by national policies and actions that are contrary and increasingly place Australia out on a limb. Australia has responded well to the COVID‐19 public health crisis (while still emerging from the bushfire crisis that preceded it) and it now needs to respond to and prepare for the health crises resulting from climate change.

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  • 1 Macquarie University, Sydney, NSW
  • 2 University of Sydney, Sydney, NSW
  • 3 Institute for Global Health, University College London, London, UK
  • 4 Queensland University of Technology, Brisbane, QLD
  • 5 Australian Institute of Health Innovation, Macquarie University, Sydney, NSW
  • 6 University Centre for Rural Health, University of Sydney, Sydney, NSW
  • 7 University Centre for Rural Health, University of Sydney, Lismore, NSW
  • 8 Monash University, Melbourne, VIC
  • 9 Integrated Sustainability Analysis, University of Sydney, Sydney, NSW
  • 10 University of Melbourne, Parkville, VIC
  • 11 Climate Change Research Centre and ARC Centre of Excellence for Climate Extremes, University of New South Wales, Sydney, NSW
  • 12 Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS
  • 13 UCL Energy Institute, University College London, London, UK
  • 14 Monash Sustainable Development Institute, Monash University, Melbourne, VIC


Correspondence: paul.beggs@mq.edu.au

Acknowledgements: 

We thank Katie Quail for assistance with indicator 1.2 Indigenous health and climate change. We thank Robert Fawcett, John Nairn (retired), Elizabeth Ebert and Bronwyn Brown (all from the Australian Bureau of Meteorology) for indicators 1.3 Health effects of heatwaves and 2.4 Climate information services for health. We thank Nathan Morris for assistance with the analysis for indicator 1.4 Heat impact on physical and sporting activities. We thank Tord Kjellstrom and Matthias Otto for providing the results for indicator 1.5 Change in labour capacity. The Bushfires indicator was generated with support from NASA Applied Sciences Program (grant no. 80NSSC21K0507) and we thank Yang Liu, Bryan Vu and Liuhua Shi (all from Emory University) for the Australian data used for this indicator (1.7), and Nicolas Borchers Arriagada (Menzies Institute for Medical Research, University of Tasmania) for assistance with analysis. Shouro Dasgupta conducted the sea level rise‐related data analysis for indicator 1.9 Migration, displacement, and environmental change. He is an author on the Lancet Countdown global report, and contributor to the sea level rise indicator. The global version of this indicator was developed in collaboration also with Ilan Kelman and Sonja Ayeb‐Karlsson. We thank Kerry Nice (University of Melbourne) who worked on indicator 2.6 Urban green space. The assistance of Zahra Borghei Ghomi (Macquarie University) in compiling the data for indicators 3.1 Carbon intensity of the energy system, 3.2 Coal phase‐out, 3.3 Zero carbon emission electricity, and 3.4 Clean household energy is acknowledged. We thank Marco Springman from the Lancet Countdown for providing the results for indicator 3.9 Diet and health co‐benefits. We thank Maddie Heenan for searching and data compilation for indicator 5.3 Government engagement in health and climate change in Australia. We thank the NHMRC for providing the data for indicator 5.4 Health and climate change research funding.

Competing interests:

No relevant disclosures.

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Towards risk‐stratified population breast cancer screening: more than mammographic density

John L Hopper and Tuong Linh Nguyen
Med J Aust 2021; 215 (8): . || doi: 10.5694/mja2.51268
Published online: 18 October 2021

Powerful new automated tools are being developed to identify the women most likely to have an existing or future cancer

The article by Noguchi and colleagues in this issue of the MJA1 is timely and motivated by an important aim: to improve breast screening for both women and its funders. The authors conducted a comprehensive analysis of routinely collected data for all screening mammograms by BreastScreen WA over the ten years from July 2007. Although they studied screening episodes rather than individual women, they found evidence that key performance indicators — screen‐detected and interval cancer rates — differed by age, family history, hormone replacement therapy use, benign breast disease, and breast density. Importantly, the strengths of the relationships between some factors and performance varied by age group.1


  • Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC


Correspondence: j.hopper@unimelb.edu.au

Acknowledgements: 

We acknowledge the generous support for our work in this area over many years from the National Breast Cancer Foundation, the Cancer Council Victoria, Cancer Australia, the National Health and Medical Research Council, and the National Institutes of Health (USA).

Competing interests:

No relevant disclosures.

  • 1. Noguchi N, Marinovich ML, Wylie EJ, et al. Screening outcomes by risk factor and age: evidence from BreastScreen WA for discussions of risk‐stratified population screening. Med J Aust 2021; 215: 359–365.
  • 2. Allweis TM, Hermann N, Bernstein‐Molho R, Guindy M. Personalized screening for breast cancer: rationale, present practices, and future directions. Ann Surg Oncol 2021; 28: 4306–4317.
  • 3. Eklund M, Broglio K, Yau C, Connor JT, et al. The WISDOM personalized breast cancer screening trial: simulation study to assess potential bias and analytic approaches. JNCI Cancer Spectr 2018; 2: pky067.
  • 4. Hopper JL, Nguyen TL, Schmidt DF, et al. Going beyond conventional mammographic density to discover novel mammogram‐based predictors of breast cancer risk. J Clin Med 2020; 9: 627.
  • 5. Boyd NF, Guo H, Martin LJ, Sun L, et al. Mammographic density and the risk and detection of breast cancer. N Engl J Med 2007; 3563: 227–236.
  • 6. Cappello NM, Richetelli D, Lee CI. The impact of breast density reporting laws on women’s awareness of density‐associated risks and conversations regarding supplemental screening with providers. J Am Coll Radiol 2019; 16: 139–146.
  • 7. Nguyen TL, Aung YK, Evans CF, et al. Mammographic density defined by higher than conventional brightness thresholds better predicts breast cancer risk. Int J Epidemiol 2017; 46: 652–661.
  • 8. Schmidt DF, Makalic E, Goudey B, et al. Cirrus: an automated mammography‐based measure of breast cancer risk based on textural features. JNCI Cancer Spectr 2018; 2: pky057.
  • 9. Nguyen TL, Schmidt DF, Makalic E, et al. Novel mammogram‐based measures improve breast cancer risk prediction beyond an established mammographic density measure. Int J Cancer 2021; 148: 2193–2202.
  • 10. Hopper JL. Genetics for population and public health. Int J Epidemiol 2017; 46: 8–11.
  • 11. Freeman K, Geppert J, Stinton C, et al. Use of artificial intelligence for image analysis in breast cancer screening programmes: systematic review of test accuracy. BMJ 2021; 374: n1872.

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Abortion care in the 21st century

Caroline M Costa and Kirsten I Black
Med J Aust 2021; 215 (8): . || doi: 10.5694/mja2.51274
Published online: 18 October 2021

Identifying inequity of access and assessing the effectiveness of interventions is difficult without systematic abortion data collection

The past two decades have seen major changes in both abortion law and abortion provision across Australia. Safe legal abortion is now available to all Australian women, and is accessible to many. Decriminalisation in all states and territories and legislated safety zones around abortion services have led to wider discussion of abortion in Australian society and softening of the attached stigma.1


  • 1 The Cairns Institute, James Cook University, Cairns, QLD
  • 2 The University of Sydney, Sydney, NSW
  • 3 Royal Prince Alfred Hospital, Sydney, NSW


Correspondence: caroline.decosta@jcu.edu.au

Competing interests:

No relevant disclosures.

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Self‐collection for HPV screening: a game changer in the elimination of cervical cancer

Karen Canfell, Megan A Smith and Deborah J Bateson
Med J Aust 2021; 215 (8): . || doi: 10.5694/mja2.51262
Published online: 18 October 2021

Self‐collection will facilitate new community‐led, co‐designed delivery models that could greatly increase the acceptability and uptake of screening

In December 2017, the Australian National Cervical Screening Program (NCSP) underwent a major renewal, transitioning from two‐yearly cytology screening for people with a cervix (“women”) aged 18‒20 to 69 years, to five‐yearly primary human papillomavirus (HPV) screening for women aged 25‒74 years. The NCSP renewal was driven by accumulated international evidence for the very high effectiveness of primary HPV screening for predicting current and future risk of pre‐cancerous lesions and invasive cancer.1 It was also prompted by the Australian HPV vaccination program that commenced in 2007, which has resulted in rapid population‐level reductions in the incidence of pre‐cancerous lesions in young women.2

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  • 1 The Daffodil Centre at the University of Sydney (Cancer Council NSW/University of Sydney), Sydney, NSW
  • 2 Family Planning New South Wales, Sydney, NSW
  • 3 The University of Sydney, Sydney, NSW


Correspondence: karen.canfell@nswcc.org.au

Acknowledgements: 

Karen Canfell receives salary support from the National Health and Medical Research Council (NHMRC; APP1194679). Megan Smith receives salary support from the NHMRC (APP1159491) and the Cancer Institute NSW (ECF181561).

Competing interests:

Karen Canfell is co‐principal investigator in an unrelated investigator‐initiated trial of cervical screening in Australia (Compass; ACTRN12613001207707 and NCT02328872), conducted and funded by the VCS Foundation, a Victorian government‐funded health promotion charity. The VCS Foundation has received equipment and a funding contribution from Roche Molecular Systems USA. Neither Karen Canfell nor her institution on her behalf (Cancer Council NSW) receives direct funding from industry for this trial or any other project.

  • 1. Ronco G, Dillner J, Elfström KM, et al; International HPV screening working group. Efficacy of HPV‐based screening for prevention of invasive cervical cancer: follow‐up of four European randomised controlled trials. Lancet 2014; 383: 524–532.
  • 2. Australian Institute of Health and Welfare. Cervical screening in Australia 2019 (Cat. no. CAN 124). May 2019. https://www.aihw.gov.au/reports/cancer‐screening/cervical‐screening‐in‐australia‐2019/summary 2019 (viewed Aug 2021).
  • 3. Lew JB, Simms KT, Smith MA, et al. Primary HPV testing versus cytology‐based cervical screening in women in Australia vaccinated for HPV and unvaccinated: effectiveness and economic assessment for the National Cervical Screening Program. Lancet Public Health 2017; 2: e96–e107.
  • 4. Creagh NS, Zammit C, Brotherton JML, et al. Self‐collection cervical screening in the renewed National Cervical Screening Program: a qualitative study. Med J Aust 2021; 215: 354–358.
  • 5. Medical Services Advisory Committee. MSAC outcomes application no. 1276. Renewal of the National Cervical Screening Program. Apr 2014. http://www.msac.gov.au/internet/msac/publishing.nsf/Content/D924E2F768B13C4BCA25801000123B9E/$File/1276%20‐%20Final%20MSAC%20PSD%20‐%20NCSP%20Renewal.pdf (viewed Aug 2021).
  • 6. Arbyn M, Smith SB, Temin S, et al; Collaboration on Self‐Sampling and HPV Testing. Detecting cervical precancer and reaching underscreened women by using HPV testing on self samples: updated meta‐analyses. BMJ 2018; 363: k4823.
  • 7. Smith MA, Hall MT, Saville M, et al. Could HPV testing on self‐collected samples be routinely used in an organized cervical screening program? A modeled analysis. Cancer Epidemiol Biomarkers Prev 2021; 30: 268–77.
  • 8. Medical Services Advisory Committee. MSAC application no. 1664 (public summary document). Apr 2021. http://www.msac.gov.au/internet/msac/publishing.nsf/Content/69F7A5B132EA653ECA258646001B5CD5/$File/1664%20Final%20PSD%20‐%20Mar‐Apr%202021.pdf (viewed Aug 2021).
  • 9. Davies‐Oliveira JC, Smith MA, Grover S, et al. Eliminating cervical cancer: progress and challenges for high‐income countries. J Clin Oncol (R Coll Radiol) 2021; 33: 550–559.
  • 10. Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018; 68: 394–424.
  • 11. World Health Organization. Global strategy to accelerate the elimination of cervical cancer as a public health problem (Report no. 9789240014107). Nov 2020. https://www.who.int/publications/i/item/9789240014107 (viewed Aug 2021).
  • 12. Hall MT, Simms KT, Lew JB, et al. The projected timeframe until cervical cancer elimination in Australia: a modelling study. Lancet Public Health 2019; 4: e19–e27.
  • 13. NHMRC Centre of Research Excellence in Cervical Cancer Control. Cervical cancer elimination progress report: Australia’s progress towards the elimination of cervical cancer as a public health problem. Mar 2021. https://www.cervicalcancercontrol.org.au/wp‐content/uploads/2021/03/2021‐C4‐CRE‐Elim‐Report.pdf (viewed Aug 2021).
  • 14. Whop LJ, Smith MA, Butler TL, et al. Achieving cervical cancer elimination among Indigenous women. Prev Med 2021; 144: 106314.

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Treatment of alcohol problems: current status and future directions

Paul S Haber, Benjamin C Riordan and Kirsten C Morley
Med J Aust 2021; 215 (7): . || doi: 10.5694/mja2.51265
Published online: 4 October 2021

Scaling up the treatment of alcohol problems will lead to considerable health benefit across the nation

Alcohol is Australia’s most widely used drug, consumed by nearly 80% of the adult population.1 We lack recent prevalence data for alcohol use disorder in Australia but previous estimates vary from about 800 0002 to over a million.3 With such large numbers, it is quite a paradox that we are not better equipped to manage those who develop problems related to its use.

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  • 1 Central Clinical School, University of Sydney, Sydney, NSW
  • 2 Edith Collins Centre (Translational Research Centre in Alcohol Drugs and Toxicology), Sydney, NSW
  • 3 Drug Health Services, Royal Prince Alfred Hospital, Sydney, NSW
  • 4 Centre for Alcohol Policy Research, Melbourne, VIC


Correspondence: paul.haber@sydney.edu.au

Competing interests:

Paul Haber has been funded by the Lambert Initiative for Cannabinoid Therapeutics at the University of Sydney to undertake clinical trials of cannabinoid treatment for alcohol withdrawal syndrome; has served on industry advisory boards for Indivior, AbbVie and Gilead; and has been an investigator on clinical trials supported by Camurus. He has also served on international and Australian advisory boards for Lundbeck in relation to nalmefene (2013–2015 and 2014, respectively).

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Screening for post‐stroke depression: who, when and how?

Katherine Sewell, Tamara Tse, Geoffrey A Donnan and Leeanne M Carey
Med J Aust 2021; 215 (7): . || doi: 10.5694/mja2.51256
Published online: 4 October 2021

What Australia can learn from overseas guidelines

Depression is a common sequela of stroke, with about 30% of stroke survivors developing depression.1 The Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM‐5) recognises post‐stroke depression within the category “Depressive disorder due to another medical condition”.2 Post‐stroke depression significantly hinders patients’ ability to participate in rehabilitation and is associated with poor health outcomes. Despite its high prevalence and negative impact, post‐stroke depression is vastly underdiagnosed.3 One estimate suggested that only 5% of stroke survivors are diagnosed with and treated for depression in routine clinical practice.4 Diagnosis of depression can be challenging in stroke survivors, especially in those who have residual communication and cognitive impairments.


  • 1 La Trobe University, Melbourne, VIC
  • 2 Florey Institute of Neuroscience and Mental Health, Melbourne, VIC
  • 3 St Vincent's Hospital, Melbourne, VIC
  • 4 Melbourne Brain Centre at The Royal Melbourne Hospital, Melbourne, VIC



Acknowledgements: 

Katherine Sewell is the recipient of a La Trobe University postgraduate scholarship for undertaking a PhD, which supported her during the writing of this article.

Competing interests:

No relevant disclosures.

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Reforming our health care system: time to rip off the band‐aid?

Claire L Jackson and Diana O’Halloran
Med J Aust 2021; 215 (7): . || doi: 10.5694/mja2.51261
Published online: 4 October 2021

The health reform imperative is clear; it now requires national courage and leadership to implement it

While Australia has traditionally delivered some of the best health care outcomes in the world,1 there are increasing signs that our strained health care system is pushing the stress performance curve into the red. Benchmarks of hospital activity demonstrate ongoing difficulty;2 Local Hospital Networks scramble to meet demand despite annual federal government funding increases of 6.5%; and the grey literature attests to the unfolding human impact behind the figures.3 Patients deteriorate waiting for specialist assessment,4 and junior doctors find themselves trapped in increasingly overstretched, dysfunctional work environments. The much‐reviewed experience of Yumiko Kadota is not an isolated incident, with similar experiences documented regularly by doctors‐in‐training nationwide.5


  • 1 University of Queensland, Brisbane, QLD
  • 2 MRI‐UQ Centre for Health System Reform and Integration, University of Queensland, Brisbane, QLD
  • 3 University of Western Sydney, Sydney, NSW


Correspondence: c.jackson@uq.edu.au

Competing interests:

No relevant disclosures.

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Adding saliva testing to oropharyngeal and deep nasal swab testing increases PCR detection of SARS‐CoV‐2 in primary care and children

Jane Oliver, Shidan Tosif, Lai‐yang Lee, Anna‐Maria Costa, Chelsea Bartel, Katherine Last, Vanessa Clifford, Andrew Daley, Nicole Allard, Catherine Orr, Ashley Nind, Karyn Alexander, Niamh Meagher, Michelle Sait, Susan A Ballard, Eloise Williams, Katherine Bond, Deborah A Williamson, Nigel W Crawford and Katherine B Gibney
Med J Aust 2021; 215 (6): . || doi: 10.5694/mja2.51188
Published online: 20 September 2021

Abstract

Objective: To compare the concordance and acceptability of saliva testing with standard‐of‐care oropharyngeal and bilateral deep nasal swab testing for severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) in children and in general practice.

Design: Prospective multicentre diagnostic validation study.

Setting: Royal Children’s Hospital, and two general practices (cohealth, West Melbourne; Cirqit Health, Altona North) in Melbourne, July–October 2020.

Participants: 1050 people who provided paired saliva and oropharyngeal‐nasal swabs for SARS‐CoV‐2 testing.

Main outcome measures: Numbers of cases in which SARS‐CoV‐2 was detected in either specimen type by real‐time polymerase chain reaction; concordance of results for paired specimens; positive percent agreement (PPA) for virus detection, by specimen type.

Results: SARS‐CoV‐2 was detected in 54 of 1050 people with assessable specimens (5%), including 19 cases (35%) in which both specimens were positive. The overall PPA was 72% (95% CI, 58–84%) for saliva and 63% (95% CI, 49–76%) for oropharyngeal‐nasal swabs. For the 35 positive specimens from people aged 10 years or more, PPA was 86% (95% CI, 70–95%) for saliva and 63% (95% CI, 45–79%) for oropharyngeal‐nasal swabs. Adding saliva testing to standard‐of‐care oropharyngeal‐nasal swab testing increased overall case detection by 59% (95% CI, 29–95%). Providing saliva was preferred to an oropharyngeal‐nasal swab by most participants (75%), including 141 of 153 children under 10 years of age (92%).

Conclusion: In children over 10 years of age and adults, saliva testing alone may be suitable for SARS‐CoV‐2 detection, while for children under 10, saliva testing may be suitable as an adjunct to oropharyngeal‐nasal swab testing for increasing case detection.

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  • 1 The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC
  • 2 The Royal Children’s Hospital, Melbourne, VIC
  • 3 Melbourne Medical School, University of Melbourne, Melbourne, VIC
  • 4 The Royal Women’s Hospital, Melbourne, VIC
  • 5 cohealth, Melbourne, VIC
  • 6 Cirqit Health, Melbourne, VIC
  • 7 The University of Melbourne, Melbourne, VIC
  • 8 Public Health Laboratory, University of Melbourne, Melbourne, VIC
  • 9 Royal Melbourne Hospital, Melbourne, VIC
  • 10 Victorian Infectious Diseases Reference Laboratory, Melbourne Health, Melbourne, VIC
  • 11 Melbourne Health, Melbourne, VIC
  • 12 Surveillance of Adverse Events Following Vaccination in the Community (SAEFVIC), Murdoch Children’s Research Institute, Melbourne, VIC


Correspondence: jane.oliver@unimelb.edu.au

Acknowledgements: 

Our study was supported by a donation from the Isabel and John Gilbertson Charitable Trust. We acknowledge all participants, and the clinical, administrative and laboratory staff who assisted our study at the Royal Children’s Hospital Melbourne, cohealth, Cirqit Health, the Microbiological Diagnostic Unit Public Health Laboratory, Golden Messenger, the Royal Melbourne Hospital, and the University of Melbourne.

Competing interests:

No relevant disclosures.

  • 1. Public Health Laboratory Network. PHLN guidance on laboratory testing for SARS‐CoV‐2 (the virus that causes COVID‐19), version 1.16. Updated Feb 2021. https://www.health.gov.au/resources/publications/phln-guidance-on-laboratory-testing-for-sars-cov-2-the-virus-that-causes-covid-19 (viewed May 2021).
  • 2. Fernandes LL, Pacheco VB, Borges L, et al. Saliva in the diagnosis of COVID‐19: a review and new research directions. J Dent Res 2020; 99: 1435–1443.
  • 3. Kivelä JM, Jarva H, Lappalainen M, Kurkela S. Saliva‐based testing for diagnosis of SARS‐CoV‐2 infection: a meta‐analysis. J Med Virol 2021; 93: 1256–1258.
  • 4. Khiabani K, Amirzade‐Iranaq MH. Are saliva and deep throat sputum as reliable as common respiratory specimens for SARS‐CoV‐2 detection? A systematic review and meta‐analysis. Am J Infect Control 2021; https://doi.org/10.1016/j.ajic.2021.03.008 [online ahead of print].
  • 5. Buban JM, Villanueva PN, Gregorio GEV. Should RT‐PCR of saliva samples be used for diagnosis of COVID‐19? (Philippine COVID‐19 Living Clinical Practice Guidelines). Updated 15 Mar 2021. https://www.psmid.org/wp-content/uploads/2021/05/SALIVA-RT-PCR-CPG-FINAL_031521_MMA.pdf (viewed May 2021).
  • 6. Tsang NNY, So HC, Ng KY, et al. Diagnostic performance of different sampling approaches for SARS‐CoV‐2 RT‐PCR testing: a systematic review and meta‐analysis. Lancet Infect Dis 2021; https://doi.org/10.1016/S1473-3099(21)00146-8 [online ahead of print].
  • 7. Zhu J, Guo J, Xu Y, Chen X. Viral dynamics of SARS‐CoV‐2 in saliva from infected patients. J Infect 2020; 81: e48–e50.
  • 8. Ruggiero A, Sanguinetti M, Gatto A, et al. Diagnosis of COVID‐19 infection in children: less nasopharyngeal swabs, more saliva. Acta Paediatr 2020; 109: 1913–1914.
  • 9. Chong CY, Kam KQ, Li J, et al. Saliva is not a useful diagnostic specimen in children with coronavirus disease 2019 [letter]. Clin Infect Dis 2020; https://doi.org/10.1093/cid/ciaa1376 [online ahead of print].
  • 10. Han MS, Seong MW, Kim N, et al. Viral RNA load in mildly symptomatic and asymptomatic children with COVID‐19, Seoul, South Korea. Emerg Infect Dis 2020; 26: 2497–2499.
  • 11. Yee R, Truong TT, Pannaraj PS, et al. Saliva is a promising alternative specimen for the detection of SARS‐CoV‐2 in children and adults. J Clin Microbiol 2021; 59: e02686–20.
  • 12. Huber M, Schreiber PW, Scheier T, et al. High efficacy of saliva in detecting SARS‐CoV‐2 by RT‐PCR in adults and children. Microorganisms 2021; 9: 642.
  • 13. Fougère Y, Schwob JM, Miauton A, et al. Performance of RT‐PCR on saliva specimens compared to nasopharyngeal swabs for the detection of SARS‐CoV‐2 in children: a prospective comparative clinical trial [preprint]. medRxiv , 1 Mar 2021. https://doi.org/10.1101/2021.02.27.21252571 (viewed May 2021).
  • 14. Felix AC, De Paula AV, Ribeiro AC, et al. Saliva as a reliable sample for COVID‐19 diagnosis in paediatric patients [preprint]. medRxiv , 31 Mar 2021. https://doi.org/10.1101/2021.03.29.21254566 (viewed May 2021).
  • 15. Al Suwaidi H, Senok A, Varghese R, et al. Saliva for molecular detection of SARS‐CoV‐2 in school‐age children. Clin Microbiol Infect 2021; https://doi.org/10.1016/j.cmi.2021.02.009 [online ahead of print].
  • 16. Department of Health and Human Services (Victoria). Assessment and testing criteria for coronavirus (COVID‐19). Updated 9 Apr 2021. https://www.dhhs.vic.gov.au/assessment-and-testing-criteria-coronavirus-covid-19 (viewed May 2021).
  • 17. Department of Health and Human Services (Victoria). Coronavirus (COVID‐19). https://www.dhhs.vic.gov.au/coronavirus (viewed May 2021).
  • 18. Cohen JF, Korevaar DA, Altman DG, et al. STARD 2015 guidelines for reporting diagnostic accuracy studies: explanation and elaboration. BMJ Open 2016; 6: e012799.
  • 19. Williams E, Bond K, Zhang B, et al. Saliva as a noninvasive specimen for detection of SARS‐CoV‐2. J Clin Microbiol 2020; 58: e00776–20.
  • 20. Ku CW, Shivani D, Kwan JQT, et al. Validation of self‐collected buccal swab and saliva as a diagnostic tool for COVID‐19. Int J Infect Dis 2021; 104: 255–261.
  • 21. Zimba R, Kulkarni S, Berry A, et al; the CHASING COVID Cohort Study Team. Testing, testing: what SARS‐CoV‐2 testing services do adults in the United States actually want? [preprint]. medRxiv, 18 Sept 2020. https://doi.org/10.1101/2020.09.15.20195180 (viewed May 2021).
  • 22. Communicable Diseases Network Australia. Coronavirus disease 2019 (COVID‐19): CDNA national guidelines for public health units; version 3.1. Updated 4 June 2020. https://www1.health.gov.au/internet/main/publishing.nsf/Content/cdna-song-novel-coronavirus.htm (viewed May 2021).
  • 23. Caulley L, Corsten M, Eapen L, et al. Salivary detection of COVID‐19. Ann Intern Med 2021; 174: 131–133.
  • 24. Byrne RL, Kay GA, Kontogianni K, et al. Saliva offers a sensitive, specific and non‐invasive alternative to upper respiratory swabs for SARS‐CoV‐2 diagnosis [pre‐print]. medRxiv, 11 July 2020. https://doi.org/10.1101/2020.07.09.20149534 (viewed May 2021).
  • 25. Landry ML, Criscuolo J, Peaper DR. Challenges in use of saliva for detection of SARS CoV‐2 RNA in symptomatic outpatients. J Clin Virol 2020; 130: 104567.
  • 26. Vogels CBF, Watkins AE, Harden CA, et al. SalivaDirect: a simplified and flexible platform to enhance SARS‐CoV‐2 testing capacity. Med (NY) 2021; 2: 263–280.
  • 27. Ceron JJ, Lamy E, Martinez‐Subiela S,et al. Use of saliva for diagnosis and monitoring the SARS‐CoV‐2: a general perspective. J Clin Med 2020; 9: 1491.

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Drug‐induced liver injury caused by herbal and dietary supplements: where to next?

Elliot Freeman and Stuart K Roberts
Med J Aust 2021; 215 (6): . || doi: 10.5694/mja2.51223
Published online: 20 September 2021

Collaboration and education are critical to understanding and managing this mounting public health problem

Drug‐induced liver injury (DILI) is a major cause of acute liver failure, leading to liver transplantation and death,1 and it is one of the most frequent safety‐related causes of drug marketing withdrawals.2 DILI poses a growing challenge for clinicians, researchers, and regulatory bodies, with a vast array of new medications and herbal and dietary supplements constantly becoming available. Despite decades of experience with drug hepatotoxicity and the relatively recent development of clinical guidelines, registries, and other collaborative resources, much is still to be learned in this important field of medicine.


  • 1 The Alfred Hospital, Melbourne, VIC
  • 2 Monash University, Melbourne, VIC


Correspondence: S.Roberts@alfred.org.au

Competing interests:

No relevant disclosures.

  • 1. Russo MW, Galanko JA, Shrestha R, et al. Liver transplantation for acute liver failure from drug induced liver injury in the United States. Liver Transplant 2004; 10: 1018–1023.
  • 2. US Department of Health and Human Services, Food and Drug Administration. Guidance for industry. Drug‐induced liver injury: premarketing clinical evaluation. July 2009. https://www.fda.gov/media/116737/download (viewed June 2021).
  • 3. Larrey D. Epidemiology and individual susceptibility to adverse drug reactions affecting the liver. Semin Liver Dis 2002; 22: 145–155.
  • 4. Nash E, Sabih AH, Chetwood J, et al. Drug‐induced liver injury in Australia, 2009–2020: the increasing proportion of non‐paracetamol cases linked with herbal and dietary supplements. Med J Aust 2021; 215: 261–268.
  • 5. Barnes J, McLachlan AJ, Sherwin CM, Enioutina EY. Herbal medicines: challenges in the modern world. Part 1. Australia and New Zealand. Expert Rev Clin Pharmacol 2016; 9: 905–915.
  • 6. Navarro VJ, Khan I, Björnsson E, et al. Liver injury from herbal and dietary supplements. Hepatology 2017; 65: 363–373.
  • 7. Luber RP, Rentsch C, Lontos S, et al. Turmeric induced liver injury: a report of two cases. Case Reports Hepatol 2019; 2019: 1–4.
  • 8. Therapeutic Goods Administration. An overview of the regulation of complementary medicines in Australia. Mar 2013. https://www.tga.gov.au/overview‐regulation‐complementary‐medicines‐australia (viewed June 2021).
  • 9. Benesic A, Leitl A, Gerbes AL. Monocyte‐derived hepatocyte‐like cells for causality assessment of idiosyncratic drug‐induced liver injury. Gut 2016; 65: 1555.
  • 10. Fontana RJ, Watkins PB, Bonkovsky HL, et al; DILIN Study Group. Drug‐Induced Liver Injury Network (DILIN) prospective study: rationale, design and conduct. Drug Safety 2009; 32: 55–68.
  • 11. National Institute of Diabetes and Digestive and Kidney Diseases. LiverTox: Clinical and research information on drug‐induced liver injury. Bethesda (MD): NIDDKD, 2012 (updated June 2021). https://www.ncbi.nlm.nih.gov/books/NBK547852 (viewed June 2021).
  • 12. Assis DN, Navarro VJ. Human drug hepatotoxicity: a contemporary clinical perspective. Expert Opin Drug Metab Toxicol 2009; 5: 463–473.

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Australian and New Zealand approach to diagnosis and management of vaccine‐induced immune thrombosis and thrombocytopenia

Vivien M Chen, Jennifer L Curnow, Huyen A Tran and Philip Y‐I Choi
Med J Aust 2021; 215 (6): . || doi: 10.5694/mja2.51229
Published online: 20 September 2021
Correction(s) for this article: Erratum | Published online: 15 November 2021
Erratum | Published online: 15 November 2021

VITT is a potential complication of ChAdOx1‐nCov‐19 vaccination — early recognition is key to improved outcomes

A syndrome of thrombosis and thrombocytopenia has been described in a small proportion of patients vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). The thrombosis can be severe and, on occasion, fatal. The syndrome has been described in patients receiving adenovirus vector ChAdOx1 nCov‐19 (AstraZeneca) or Ad26.COV2.S (Johnson & Johnson–Janssen) encoding SARS‐CoV‐2 spike protein.1,2,3,4

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  • 1 Concord Hospital, Sydney, NSW
  • 2 ANZAC Research Institute, University of Sydney, Sydney, NSW
  • 3 Westmead Hospital, Sydney, NSW
  • 4 Alfred Hospital, Melbourne, VIC
  • 5 Central Clinical School, Monash University, Melbourne, VIC
  • 6 Canberra Hospital, Canberra, ACT


Correspondence: vivien.chen@sydney.edu.au

Acknowledgements: 

This guidance has been produced with ongoing critical review and support from the entire THSANZ VITT advisory group: Vivien Chen (Concord Hospital, Sydney); Huyen Tran (Alfred Hospital, Melbourne); Philip Choi (The Canberra Hospital, ACT); Jennifer Curnow (Westmead Hospital, Sydney); Sanjeev Chunilal (Monash Medical Centre, Melbourne); Christopher Ward (Royal North Shore Hospital, Sydney); Freda Passam (Royal Prince Alfred Hospital, Sydney); Timothy Brighton (Prince of Wales Hospital, Sydney); Beng Chong (St George Hospital, Sydney); Robert Bird (Princess Alexandra Hospital, Brisbane); Anoop Enjeti (John Hunter Hospital, Newcastle); Leonardo Pasalic (ICPMR, Sydney); Emmanuel Favaloro (ICPMR, Sydney); Chee Wee Tan (Royal Adelaide Hospital, Adelaide); Ross Baker (Perth Blood Institute, Murdoch University, WA); Simon McCrae (Launceston Hospital, Tasmania); Ibrahim Tohidi‐Esfahani (ANZAC Research Institute. Sydney); Elizabeth Gardiner (Australian National University, Canberra); Joanne Joseph (St Vincent’s hospital, Sydney); Danny Hsu (Liverpool hospital, Sydney); Laura Young (Auckland City Hospital, NZ); Claire McClintock (Auckland City Hospital, NZ); and Eileen Merriman (Waitemata, NZ). We also thank Haematology Society of Australia and New Zealand contributors Steven Lane and Leanne Berkhan.

Competing interests:

No relevant disclosures.

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