To the Editor: We report a case in which the concurrent administration of colchicine and simvastatin led to significant morbidity with myopathy and intestinal dysfunction.
The full article is accessible to AMA members and paid subscribers. Login to read more or purchase a subscription now.
Please note: institutional and Research4Life access to the MJA is now provided through Wiley Online Library.
- 1. Justiniano M, Dold S, Espinoza LR. Rapid onset of muscle weakness (rhabdomyolysis) associated with the combined use of simvastatin and colchicine. J Clin Rheumatol 2007; 13: 266-268.
- 2. US Food and Drug Administration. FDA drug safety communication: revised dose limitation for Zocor (simvastatin) when taken with amiodarone. http://www.fda.gov/Drugs/DrugSafety/ucm283137.htm (accessed Apr 2012).
- 3. Edholm B. Statin-induced dysphagia [Danish]. Ugeskr Laeger 2010; 172: 544-545.
- 4. Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981; 30: 239-245.
- 5. Marfia GA, Pachatz C, Arciprete F, et al. Intestinal pseudobstruction as presenting event of fatal cerivastatin-induced myopathy. J Neurol 2003; 250: 887-888.
Online responses are no longer available. Please refer to our instructions for authors page for more information.
No relevant disclosures.