To the Editor: Cyanocobalamin and hydroxycobalamin are synthetically derived preparations of vitamin B12. Allergy to vitamin B12 injection is infrequent, but may be serious. We describe a patient with allergy to hydroxycobalamin, without cross-reaction to cyanocobalamin.
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Correspondence: David_Heyworth-Smith@health.qld.gov.au
- 1. Woodliff HJ. Allergic reaction to cyanocobalamin injection. Med J Aust 1986; 144: 223.
- 2. De Blay F, Sager MF, Hirth C, et al. IgE mediated reaction to hydroxycobalamin injection in a patient with pernicious anaemia. Lancet 1992; 339: 1535-1536.
- 3. Vidal C, Lorenzo A. 1998 Anaphylactoid reaction to hydroxycobalamin with tolerance of cyanocobalamin. Postgrad Med J 1998; 74: 702.
- 4. Cobcroft R, Cobcroft S. Oral vitamin B12 for B12 deficiency [letter]. Med J Aust 1999; 170: 451.
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