The biology of colorectal cancer provides an important opportunity for cancer prevention, as most cancers in the lower bowel evolve from polyps (adenomas). Removal of adenomas markedly reduces the subsequent risk of disease. Consequently, the rational aim of any prevention program should be not only to detect early cancer but also the precursor adenoma. The strategies to reduce mortality include:
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- 1. National Health and Medical Research Council. Guidelines for the prevention, early detection and management of colorectal cancer. Canberra: NHMRC, 1999.
- 2. Johns LE, Houston RS. A systematic review and meta-analysis of familial colorectal cancer risk. Am J Gastroenterol 2001; 96: 2992-3003.
- 3. Winawer SJ, Zauber AG, Ho MN, et al. Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup. N Engl J Med 1993; 329: 1977-1981.
- 4. Rex DK, Cutler CS, Lemmel GT, et al. Colonoscopic miss rates of adenomas determined by back-to-back colonoscopies. Gastroenterology 1997; 112(1): 24–28.
- 5. Yusoff IF, Hoffman NE, Hooi CE. Colonoscopic surveillance for family history of colorectal cancer: are NHMRC guidelines being followed? Med J Aust 2002; 176: 151-154. <eMJA full text>
- 6. Bampton PA, Sandford JJ, Young GP. Applying evidence-based guidelines improves use of colonoscopy resources in patients with a moderate risk of colorectal neoplasia. Med J Aust 2002; 176: 155-157. <eMJA full text>
- 7. Mandel JS, Bond JH, Church TR, et al. Reducing mortality from colorectal cancer by screening for faecal occult blood. Minnesota Colon Cancer Control Study. N Engl J Med 1993; 328: 1365-1371. >
- 8. Hardcastle JD, Chamberlain JO, Robinson MH, et al. Randomised controlled trial of faecal-occult-blood screening for colorectal cancer. Lancet 1996; 348: 1472-1477.
- 9. Kronborg O, Fenger C, Olsen J, et al. Randomised study of screening for colorectal cancer with faecal-occult-blood test. Lancet 1996; 348: 1467-1471.
- 10. Lieberman DA, Weiss DG. One-time screening for colorectal cancer with combined faecal occult-blood testing and examinations of the distal colon. N Engl J Med 2001; 345: 555- 560.
- 11. Bolin TD, Korman MG, Stanton R, et al. Positive cost effectiveness of early diagnosis of colorectal cancer. Colorectal Dis 1999; 1: 113-122.
- 12. Rex DK, Lieberman DA. Feasibility of colonoscopy screening: discussion of issues and recommendations regarding implementation. Gastrointest Endosc 2001; 54: 662-666.
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None declared.