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The WHO resolution on sepsis: what action is needed in Australia?

Luregn J Schlapbach, Kelly Thompson and Simon R Finfer
Med J Aust 2019; 211 (9): . || doi: 10.5694/mja2.50279
Published online: 5 August 2019

Australia needs a coordinated nationwide plan to reduce preventable deaths and disability from sepsis


  • 1 Child Health Research Centre, University of Queensland, Brisbane, QLD
  • 2 The George Institute for Global Health, University of New South Wales, Sydney, NSW



Competing interests:

No relevant disclosures.

  • 1. Reinhart K, Daniels R, Kissoon N, et al. Recognizing sepsis as a global health priority – a WHO resolution. N Engl J Med 2017; 377: 414–417.
  • 2. Liu V, Escobar GJ, Greene JD, et al. Hospital deaths in patients with sepsis from 2 independent cohorts. JAMA 2014; 312: 90–92.
  • 3. Kaukonen KM, Bailey M, Suzuki S, et al. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000‐2012. JAMA 2014; 311: 1308–1316.
  • 4. Schlapbach LJ, Straney L, Alexander J, et al. Mortality related to invasive infections, sepsis, and septic shock in critically ill children in Australia and New Zealand, 2002‐13: a multicentre retrospective cohort study. Lancet Infect Dis 2015; 15: 46–54.
  • 5. Churpek MM, Snyder A, Han X, et al. Quick Sepsis‐related Organ Failure Assessment, systemic inflammatory response syndrome, and early warning scores for detecting clinical deterioration in infected patients outside the intensive care unit. Am J Respir Crit Care Med 2017; 195: 906–11.
  • 6. Heldens M, Schout M, Hammond NE, et al. Sepsis incidence and mortality are underestimated in Australian intensive care unit administrative data. Med J Aust 2018; 209: 255–260. https://www.mja.com.au/journal/2018/209/6/sepsis-incidence-and-mortality-are-underestimated-australian-intensive-care-unit
  • 7. Machado FR, Nsutebu E, AbDulaziz S, et al. Sepsis 3 from the perspective of clinicians and quality improvement initiatives. J Crit Care 2017; 40: 315–317.
  • 8. Rudd KE, Delaney A, Finfer S. Counting sepsis, an imprecise but improving science. JAMA 2017; 318: 1228–1229.
  • 9. Prescott HC, Angus DC. Enhancing recovery from sepsis: a review. JAMA 2018; 319: 62–75.
  • 10. Seymour CW, Gesten F, Prescott HC, et al. Time to treatment and mortality during mandated emergency care for sepsis. N Engl J Med 2017; 376: 2235–2244.
  • 11. Parliamentary and Health Service Ombudsman. Time to Act: Severe sepsis – rapid diagnosis and treatment saves lives. London: Parliamentary and Health Service Ombudsman, 2013.
  • 12. Burrell AR, McLaws ML, Fullick M, et al. SEPSIS KILLS: early intervention saves lives. Med J Aust 2016; 204: 73–73.e7. https://www.mja.com.au/journal/2016/204/2/sepsis-kills-early-intervention-saves-lives;
  • 13. Thursky K, Lingaratnam S, Jayarajan J, et al. Implementation of a whole of hospital sepsis clinical pathway in a cancer hospital: impact on sepsis management, outcomes and costs. BMJ Open Quality 2018; 7: e000355.
  • 14. Rhodes A, Evans LE, Alhazzani W, et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Med 2017; 43: 304–377.
  • 15. Launay E, Gras‐Le Guen C, Martinot A, et al. Why children with severe bacterial infection die: a population‐based study of determinants and consequences of suboptimal care with a special emphasis on methodological issues. PLoS One 2014; 9: e107286.
  • 16. Fleischmann C, Scherag A, Adhikari NK, et al. Assessment of global incidence and mortality of hospital‐treated sepsis. Current estimates and limitations. Am J Respir Crit Care Med 2016; 193: 259–272.
  • 17. Ostrowski JA, MacLaren G, Alexander J, et al. The burden of invasive infections in critically ill Indigenous children in Australia. Med J Aust 2017; 206: 78–84. https://www.mja.com.au/journal/2017/206/2/burden-invasive-infections-critically-ill-indigenous-children-australia
  • 18. Einsiedel LJ, Fernandes LA, Woodman RJ. Racial disparities in infection‐related mortality at Alice Springs Hospital, Central Australia, 2000–2005. Med J Aust 2008; 188: 568–571. https://www.mja.com.au/journal/2008/188/10/racial-disparities-infection-related-mortality-alice-springs-hospital-central

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