To the Editor: Bateson and Black1 do a great service in encouraging clinicians to discuss pre‐conception care with women of reproductive age.1 However, in relation to infection prevention, one area not discussed was cytomegalovirus (CMV) infection, which is the most common infectious cause and the second most common aetiology of all causes of severe congenital malformations.2 Mother to child transmission of CMV can result in prematurity, stillbirth, cerebral palsy and neurodevelopmental delay and is the most common infectious cause of hearing loss.2 Discussions about CMV prevention should ideally commence before pregnancy, as maternal CMV infection in the first trimester poses the greatest risk of harm to the fetus if mother to child transmission occurs. Such discussions should continue throughout pregnancy, as secondary maternal infection with a different strain of CMV can also result in mother to child transmission of virus,2 although the risk per infectious event is lower.
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- 1. Bateson DJ, Black KI. Pre‐conception care: an important yet underutilised preventive care strategy. Med J Aust 2018; 209: 389–390. https://www.mja.com.au/journal/2018/209/9/pre-conception-care-important-yet-underutilised-preventive-care-strategy
- 2. Rawlinson WD, Boppana SB, Fowler KB, et al. Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy. Lancet Infect Dis 2018; 17: e177–e188.
- 3. Revello MG, Tibaldi C, Masuelli G, et al. Prevention of primary cytomegalovirus infection in pregnancy. EBioMedicine 2015; 2: 1205–1210.
- 4. Royal Australian and New Zealand College of Obstetricians and Gynaecologists. Prevention of congenital cytomegalovirus (CMV) infection. RANZCOG, 2019. https://www.ranzcog.edu.au/RANZCOG_SITE/media/RANZCOG-MEDIA/Women%27s%20Health/Statement%20and%20guidelines/Clinical-Obstetrics/Prevention-of-congenital-cytomeglovirus(CMV)infection-(C-Obs-64)-New-Statement-March-2019-Amended.pdf?ext=.pdf (viewed Apr 2019).
- 5. Lazzaro A, Vo M, Zeltzer J, et al. Knowledge of congenital cytomegalovirus (CMV) in pregnant women in New South Wales (NSW) is low and improved with education. Aust N Z Obstet Gynaecol 2018; 58: 18.
- 6. Shand AW, Luk W, Nassar N, et al. Cytomegalovirus (CMV) infection and pregnancy‐potential for improvements in Australasian maternity health providers’ knowledge. J Matern Fetal Neonatal Med 2018; 31: 2515–2520.
We thank Hayley Smithers‐Sheedy (Cerebral Palsy Alliance), Kate Daly (CMV Australia), and Lisa Hui (Mercy Hospital Melbourne) for their comments on this manuscript.
No relevant disclosures