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HLA-B*5801: a genetic susceptibility to allopurinol-induced DRESS

Augustine N Mugwagwa, Roy Fischer and Izwan Zailan
Med J Aust 2016; 204 (4): . || doi: 10.5694/mja15.01113
Published online: 7 March 2016

Clinical record


  • 1 Lyell McEwin Hospital, Adelaide, SA
  • 2 School of Medicine, University of Adelaide, Adelaide, SA



Competing interests:

No relevant disclosures.

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  • 3. Hung SI, Chung WH, Liou LB, et al. HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol. Proc Natl Acad Sci U S A 2005; 102: 4134-4139.
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  • 7. Saokaew S, Tassaneeyakul W, Maenthaisong R, et al. Cost-effectiveness analysis of HLA-B*5801 testing in preventing allopurinol-induced SJS/TEN in Thai population. PLoS One 2014; 9: e94294.
  • 8. Australian Medicines Handbook. Adelaide: Australian Medicines Handbook Pty Ltd, 2015.
  • 9. Rheumatology Expert Group. Therapeutic guidelines: rheumatology. Version 2. Melbourne: Therapeutic Guidelines Limited, 2010.
  • 10. Australian Government Department of Health. Pharmaceutical Benefits Scheme [website]. http://www.pbs.gov.au (accessed Sep 2015).

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