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Post-artesunate delayed haemolysis in severe imported Plasmodium falciparum malaria

Ruchir Chavada, Siong H Hui, Sean O'Connor, Satoshi Akima and Iain B Gosbell
Med J Aust 2015; 203 (9): . || doi: 10.5694/mja15.00565
Published online: 2 November 2015

We report a case of post-artesunate delayed haemolysis (PADH) in severe Plasmodium falciparum malaria.


  • 1 Liverpool Hospital, Sydney, NSW
  • 2 Sydney South West Pathology Service, Sydney, NSW
  • 3 Campbelltown Hospital, Sydney, NSW
  • 4 University of Western Sydney, Sydney, NSW
  • 5 Ingham Institute for Applied Medical Research, Sydney, NSW


Correspondence: ruchirchavda@gmail.com

Competing interests:

No relevant disclosures.

  • 1. Packowski M, Landman K, Arguin P. Update on cases of delayed haemolysis after parenteral artesunate therapy for malaria-United States, 2008 and 2013. MMWR 2014; 63: 753-755.
  • 2. Askling HH, Bruneel F, Burchard G, et al. Management of imported malaria in Europe. Malar J 2012, 11: 328.
  • 3. Rehman K, Lotsch F, Kremsner PG, Ramharter M. Haemolysis associated with the treatment of malaria with artemisinin derivatives: a systematic review of current evidence. Int J Infect Dis. 2014; 29: 268-273.
  • 4. Plewes K, Haider MS, Kingston HW, et al. Severe falciparum malaria treated with artesunate complicated by delayed onset haemolysis and acute kidney injury. Malar J 2015; 14: 246.
  • 5. Lee J, Krajden S, Graham C, et al. Severe delayed haemolysis associated with regulated parenteral antimalarial drug. Emerg Infect Dis 2015; 21: 164-166.

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