To the Editor: Pharmacometrics is an emerging field in Australia, with use in a wide range of therapeutic areas including cardiovascular disease, critical patient care, diabetes and paediatrics.1-4 The results of pharmacometric analyses are often referred to in Therapeutic Goods Administration-approved product information; however, for many clinicians, pharmacometrics remains a mysterious area of research. Therefore, we seek to promote the discipline of pharmacometrics in clinical practice.
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- 1. Roberts JA. Using PK/PD to optimize antibiotic dosing for critically ill patients. Curr Pharm Biotechnol 2011; 12: 2070-2079.
- 2. Gulati A, Faed JM, Isbister GK, Duffull SB. Development and evaluation of a prototype of a novel clotting time test to monitor enoxaparin. Pharm Res 2012; 29: 225-235.
- 3. Duong JK, Kumar SS, Kirkpatrick CM, et al. Population pharmacokinetics of metformin in healthy subjects and patients with type 2 diabetes mellitus: simulation of doses according to renal function. Clin Pharmacokinet 2013; 52: 373-384.
- 4. Charles BG, Townsend SR, Steer PA, et al. Caffeine citrate treatment for extremely premature infants with apnea: population pharmacokinetics, absolute bioavailability, and implications for therapeutic drug monitoring. Ther Drug Monit 2008; 30: 709-716.
- 5. Waldman SA, Terzic A. Advancing pharmacometrics and systems pharmacology. Clin Pharmacol Ther 2012; 92: 535-537.
- 6. Ette EI, Williams PJ. Pharmacometrics: the science of quantitative pharmacology. Hoboken, NJ: Wiley, 2006.
- 7. Tett SE, Holford NHG, McLachlan AJ. Population pharmacokinetics and pharmacodynamics: an underutilized resource. Drug Inf J 1998; 32: 693-710.
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