Young‐onset dementia diagnosis, management and care

Loi, Samantha M; Cations, Monica; Velakoulis, Dennis

doi:10.5694/mja2.51995

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In reply: We thank Bahlo1 for the response to our narrative review2 and agree that the developments in whole genome sequencing (WGS) justify increased use of this technique in determining genetic abnormalities in young‐onset dementia. The C9orf72 repeat expansion is the most important genetic cause of frontotemporal dementia.3

1 University of Melbourne, Melbourne, VIC
2 Royal Melbourne Hospital, Melbourne, VIC
3 Flinders University, Adelaide, SA

Correspondence: samantha.loi@unimelb.edu.au

Competing interests:

No relevant disclosures.

1. Bahlo M. Young‐onset dementia diagnosis, management and care [letter]. Med J Aust 2023; 219: 90.
2. Loi SM, Cations M, Velakoulis D. Young‐onset dementia diagnosis, management and care: a narrative review. Med J Aust 2023; 218: 182‐189. https://www.mja.com.au/journal/2023/218/4/young‐onset‐dementia‐diagnosis‐management‐and‐care‐narrative‐review
3. Olszewska DA, Lonergan R, Fallon EM, Lynch T. Genetics of frontotemporal dementia. Curr Neurol Neurosci Rep 2016; 16: 107.

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