A surveillance clinic for children and adolescents with, or at risk of, hereditary cancer predisposition syndromes

Leedman, Nicholas; Princehorn, Murray; Gottardo, Nicholas; Franklin, Claire; D'Souza, Rebecca; Kiraly‐Borri, Catherine E

doi:10.5694/mja2.51002

Topics

To the Editor: Hereditary cancer predisposition syndromes (HCPS) account for at least 10% of paediatric cancers.1 Li‐Fraumeni syndrome (LFS) is a dominant HCPS caused by mutations in the TP53 gene and is associated with an 80–90% lifetime risk of cancer, commencing in infancy.2 Children of affected individuals are at 50% risk of inheriting the family mutation.

1 University of Western Australia, Perth, WA, Australia
2 Perth Children’s Hospital, Perth, WA, Australia
3 Telethon Kids Cancer Centre, Brain tumour Research Program, Telethon Kids Institute, Perth, WA, Australia
4 Genetic Services of Western Australia, Perth, WA, Australia

Correspondence: cathy.kiraly-borri@health.wa.gov.au

Competing interests:

No relevant disclosures.

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