New assessment and treatment opportunities for people with severe asthma promise better outcomes
“It’s been a long time coming, but I feel great now.” “I feel like I’ve got my life back.” These are statements made by patients with severe asthma who have had positive responses to targeted monoclonal antibody therapy for asthma. Both patients have severe refractory eosinophilic asthma and have experienced many years of persistent symptoms despite daily maintenance prednisone. On monoclonal antibody therapy, they achieved complete symptom control and significant prednisone reduction.
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- 1. Upham JW, Chung LP. Optimising treatment for severe asthma. Med J Aust 2018; 209 (2 Suppl): S22-S27.
- 2. Lindstrom SJ, Silver JD, Sutherland MF, et al. Thunderstorm asthma outbreak of November 2016: a natural disaster requiring planning. Med J Aust 2017; 207: 235-237. <MJA full text>
- 3. McDonald VM, Hiles SA, Jones KA, et al. Health-related quality of life burden in severe asthma. Med J Aust 2018; 209 (2 Suppl): S28-S33.
- 4. Israel E, Reddel HK. Severe and difficult-to-treat asthma in adults. N Engl J Med 2017; 377: 965-976.
- 5. Tay TR, Lee JW-Y, Hew M. Diagnosis of severe asthma. Med J Aust 2018; 209 (2 Suppl): S3-S10.
- 6. Chung LP, Johnson P, Summers Q. Models of care for severe asthma: the role of primary care. Med J Aust 2018; 209 (2 Suppl): S34-S40.
- 7. Bardin PG, Rangaswamy J, Yo SW. Managing comorbid conditions in severe asthma. Med J Aust 2018; 209 (2 Suppl): S11-S17.
- 8. Ramsahai JM, Wark P. Appropriate use of oral steroids in severe asthma. Med J Aust 2018; 209 (2 Suppl): S18-S21.
- 9. Department of Health. An outcomes strategy for people with chronic obstructive pulmonary disease (COPD) and asthma in England. London: Department of Health, 2011. http://www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidance/DH_127974 (accessed May 2018).
- 10. von Bulow A, Kriegbaum M, Backer V, Porsbjerg C. The prevalence of severe asthma and low asthma control among Danish adults. J Allergy Clin Immunol Pract 2014; 2: 759-767.
- 11. Hekking PP, Wener RR, Amelink M, et al. The prevalence of severe refractory asthma. J Allergy Clin Immunol 2015; 135: 896-902.
- 12. Kane B, Cramb S, Hudson V, et al. Specialised commissioning for severe asthma: oxymoron or opportunity? Thorax 2016; 71: 196-198.
I have received honoraria for the delivery of independent medical education and grants from GlaxoSmithKline, AstraZeneca and Novartis. I am also a member of the MJA Editorial Advisory Group.