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Clozapine-induced maculopathy

Heather G Mack and RC Andrew Symons
Med J Aust 2017; 207 (7): . || doi: 10.5694/mja17.00384
Published online: 2 October 2017

We thank Tong and colleagues1 for their report on a patient with schizophrenia and clozapine-induced maculopathy, and for highlighting this under-recognised condition.


  • 1 University of Melbourne, Melbourne, VIC
  • 2 Melbourne Health, Melbourne, VIC


Correspondence: hmack@eyesurgery.com.au

Competing interests:

No relevant disclosures.

  • 1. Tong JY, Pai A, Heydon P, Young SH. Clozapine-induced maculopathy. Med J Aust 2017; 206: 246. <MJA full text>
  • 2. Richa S, Yazbek JC. Ocular adverse effects of common psychotropic agents: a review. CNS Drugs 2010; 24: 501-526.
  • 3. Faure C, Audo I, Zeitz C, Letessier JB, Robert MP. Aripiprazole-induced chorioretinopathy: multimodal imaging and electrophysiological features. Doc Ophthalmol 2015; 131: 35-41.
  • 4. Lee MS, Fern AI. Fluphenazine and its toxic maculopathy. Ophthalmic Res 2004; 36: 237-239.
  • 5. Borovik AM, Bosch MM, Watson SL. Ocular pigmentation associated with clozapine. Med J Aust 2009; 190: 210-211. <MJA full text>
  • 6. Clemens CR, Alten F, Loos D, et al. Poppers maculopathy or retinopathy? Eye 2015; 29: 148-149.
  • 7. Ascaso FJ, Rodriguez-Jimenez R, Cabezón L, et al. Retinal nerve fiber layer and macular thickness in patients with schizophrenia: Influence of recent illness episodes. Psychiatry Res 2015; 229: 230-236.

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