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Severe GHB withdrawal delirium managed with dexmedetomidine

Emma MY Tay, Robert I Graham and Richard O Day
Med J Aust 2016; 205 (6): . || doi: 10.5694/mja16.00269
Published online: 19 September 2016

Clinical record


  • 1 Western Sydney Local Health District, Sydney, NSW
  • 2 St Vincent's Hospital, Sydney, NSW
  • 3 St Vincent's Clinical School, UNSW, Sydney, NSW


Correspondence: emma.tay@svha.org.au

Competing interests:

No relevant disclosures.

  • 1. Schep LJ, Knudsen K, Slaughter RJ, et al. The clinical toxicology of γ-hydroxybutyrate, γ-butyrolactone and 1,4-butanediol. Clin Toxicol (Phila) 2012; 50: 458-470.
  • 2. World Health Organization Expert Committee on Drug Dependence. Gamma-hydroxybutyric acid (GHB): critical review report. WHO, 35th meeting, Hammamet, Tunisia, 4–8 June 2012. http://www.who.int/medicines/areas/quality_safety/4.1GHBcritical_review.pdf (accessed July 2016).
  • 3. Snead OC, Gibson KM. γ-Hydroxybutyric acid. N Engl J Med 2005; 352: 2721-2732.
  • 4. Meyer R, Jenewein J, Boettger S. Management of γ-butyrolactone dependence with assisted self-administration of GBL. Case Rep Neurol Med 2014; 2014: 485178.
  • 5. Reade MC, Finfer S. Sedation and delirium in the intensive care unit. N Engl J Med 2014; 370: 444-454.

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