Connect
MJA
MJA

Hereditary leiomyomatosis and renal cell carcinoma syndrome

Nira Chinniah and Patricia Lowe
Med J Aust 2015; 203 (2): . || doi: 10.5694/mja15.00292
Published online: 20 July 2015

To the Editor: A 52-year-old woman was referred in 2003 for cutaneous examination following excision and radiotherapy of a left tonsillar squamous cell carcinoma in 2000. Her personal history was remarkable for her developing asymptomatic cutaneous nodules since the age of 20 years and uterine fibroids requiring hysterectomy at 28 years; she underwent bilateral oophorectomy for symptomatic ovarian cysts at the age of 48. She had a family history of early-onset uterine fibroids.


  • Royal Prince Alfred Hospital, Sydney, NSW.


Correspondence: patricia.lowe@sydney.edu.au

Competing interests:

No relevant disclosures.

  • 1. Alam NA, Olpin S, Leigh IM. Fumarate hydratase mutations and predisposition to cutaneous leiomyomas, uterine leiomyomas and renal cancer. Br J Dermatol 2005; 153: 11-17.
  • 2. Henley ND, Tokarz VA. Multiple cutaneous and uterine leiomyomatosis in a 36-year-old female, and discussion of hereditary leiomyomatosis and renal cell carcinoma. Int J Dermatol 2012; 51: 1213-1216.
  • 3. Pithukpakorn M, Toro JR. Hereditary leiomyomatosis and renal cell cancer. In: Pagon RA, Adam MP, Ardinger HH, et al, editors, GeneReviews. Seattle (WA): University of Washington. Updated Nov 2010. http://www.ncbi.nlm.nih.gov/books/NBK1252/ (accessed May 2015).
  • 4. Schmidt LS, Linehan WM. Hereditary leiomyomatosis and renal cell carcinoma. Int J Nephrol Renovasc Dis 2014; 7: 253-260.

Author

remove_circle_outline Delete Author
add_circle_outline Add Author

Comment
Do you have any competing interests to declare? *

I/we agree to assign copyright to the Medical Journal of Australia and agree to the Conditions of publication *
I/we agree to the Terms of use of the Medical Journal of Australia *
Email me when people comment on this article

Online responses are no longer available. Please refer to our instructions for authors page for more information.