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Sentinel lymph node biopsy for melanoma: an important risk-stratification tool

Samuel S Zagarella, Michael Sladden, Catalin Popescu and Michael Bigby
Med J Aust 2015; 202 (2): . || doi: 10.5694/mja14.01569
Published online: 2 February 2015

To the Editor: The article by Gyorki and Henderson1 is misleading and inaccurate. The stated primary outcome of the Multicenter Selective Lymphadenectomy Trial-1 (MSLT-1) was:


  • 1 Concord Hospital, Sydney, NSW.
  • 2 University of Tasmania, Launceston, TAS.
  • 3 Carol Davila University of Medicine and Pharmacy, Bucuresti, Romania.
  • 4 Beth Israel Deaconess Medical Center, Boston, Mass, USA.


Correspondence: samuelzagarella@hotmail.com

Competing interests:

No relevant disclosures.

  • 1. Gyorki DE, Henderson MA. Sentinel lymph node biopsy for melanoma: an important risk-stratification tool. Med J Aust 2014; 201: 442-444. <MJA full text>
  • 2. ClinicalTrials.gov. A service of the U.S. National Institutes of Health. Multicenter Selective Lymphadenectomy Trial (MSLT). http://clinicaltrials.gov/ct2/show/NCT00275496?term=NCT00275496&rank=1 (accessed Nov 2014).
  • 3. Morton DL, Thompson JF, Cochran AJ, et al. Final trial report of sentinel-node biopsy versus nodal observation in melanoma. N Engl J Med 2014; 370: 599-609.
  • 4. Sladden M, Zagarella S, Popescu C, Bigby M. No survival benefit for melanoma patients undergoing sentinel lymph node biopsy: critical appraisal of the multicenter selective lymphadenectomy trial-1 final report. Br J Dermatol 2015. In press.
  • 5. Mitra A, Conway C, Walker C, et al. Melanoma sentinel node biopsy and prediction models for relapse and overall survival. Br J Cancer 2010; 103: 1229-1236.

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