Eliminating childhood lead toxicity in Australia: a call to lower the intervention level

In reply: In epidemiology, the weight-of-evidence approach is useful for reaching general conclusions, whereas details from selected studies are useful for understanding nuances. This is particularly important when evidence from human and experimental research is consistent across multiple studies and in populations with different characteristics, including Australia.1-3 There will always be limitations and unmeasured confounders, but, ultimately, we can rely on controlled laboratory studies which show that lead is toxic, even at picomolar concentrations.1,4