In reply: Although our trial1 did not decrease quit rates with an intensive intervention, health professionals should continue to deliver appropriate intensive smoking interventions to pregnant Indigenous women.2 Guidelines advise the exercise of caution with the use of nicotine replacement therapy (NRT) in pregnancy,3 given the lack of trial data supporting its use.4 A recent trial of NRT in pregnancy found similar rates of adverse pregnancy and birth outcomes among women who used NRT and those who did not.5 Our study recommended NRT after at least two attempts to quit without NRT. NRT gum was prescribed by the treating doctors, with a preference for intermittent doses rather than continuous low doses through the use of NRT patches, in line with current guidelines.3 Women were provided with a week’s supply of NRT but, for reasons that were not clear, none returned for repeat supplies. The frequency with which NRT was prescribed, provided and used by women was not recorded with sufficient accuracy to allow interpretation. No definite conclusions about the efficacy of NRT can be drawn from our study and further research is necessary.
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- 1. Eades SJ, Sanson-Fisher RW, Wenitong M, et al. An intensive smoking intervention for pregnant Aboriginal and Torres Strait Islander women: a randomised controlled trial. Med J Aust 2012; 197: 42-46. <MJA full text>
- 2. Lumley J, Chamberlain C, Dowswell T, et al. Interventions for promoting smoking cessation during pregnancy. Cochrane Database Syst Rev 2009; (1): CD001055.
- 3. Zwar N, Richmond R, Borland R, et al. Supporting smoking cessation: a guide for health professionals. Melbourne: Royal Australian College of General Practitioners, 2011.
- 4. Coleman T, Chamberlain C, Cooper S, Leonardi-Bee J. Efficacy and safety of nicotine replacement therapy for smoking cessation in pregnancy: systematic review and meta-analysis. Addiction 2011; 106: 52-61.
- 5. Coleman T, Cooper S, Thornton JG, et al. A randomized trial of nicotine replacement therapy patches in pregnancy. N Engl J Med 2012; 366: 808-818.
We acknowledge our coauthors in the original study: Mark Wenitong, Catherine D’Este, Conor Gilligan and Jessica Stewart.
No relevant disclosures.