Reducing the impact of colorectal cancer
Colorectal cancer (CRC) is one of the most common cancers in Australia, with a risk in people under the age of 75 years of one in 18 for men and one in 26 for women. Each year, about 15 000 Australians are diagnosed with CRC, and about 4000 die from it.1 the 5-year survival from CRC is 62%, which is considerably worse than, for example, breast cancer, which has a 5-year survival of 88%.2
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- 1. Australian Institute of Health and Welfare. Australian cancer incidence and mortality books: bowel cancer. Canberra: AIHW, 2010. http://www.aihw.gov.au/acim-books/ (accessed Oct 2012).
- 2. Australian Institute of Health and Welfare. Cancer survival and prevalence in Australia: cancers diagnosed from 1982 to 2004. Canberra: AIHW, 2008. (AIHW Cat. No. CAN 38.) http://www.aihw.gov.au/publication-detail/?id=6442468141 (accessed Oct 2012).
- 3. Lichtenstein P, Holm NV, Verkasalo PK, et al. Environmental and heritable factors in the causation of cancer — analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med 2000; 343: 78-85.
- 4. Rustgi AK. the genetics of hereditary colon cancer. Genes Dev 2007; 21: 2525-2538.
- 5. Australasian Colorectal Cancer Family Registry. Melbourne: Cancer Council Victoria, 2012. http://www.pedigree.org.au/pedigree-studies/accfr.aspx (accessed Sep 2012).
- 6. Win AK, Dowty JG, English DR, et al. Body mass index in early adulthood and colorectal cancer risk for carriers and non-carriers of germline mutations in DNA mismatch repair genes. Br J Cancer 2011; 105: 162-169.
- 7. Win AK, Young JP, Lindor NM, et al. Colorectal and other cancer risks for carriers and noncarriers from families with a DNA mismatch repair gene mutation: a prospective cohort study. J Clin Oncol 2012; 30: 958-964.
- 8. Lindor NM, Rabe K, Petersen GM, et al. Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type X. JAMA 2005; 293: 1979-1985.
- 9. Dunlop MG, Tenesa a, Farrington SM, et al. Cumulative impact of common genetic variants and other risk factors on colorectal cancer risk in 42 103 individuals. Gut 2012; May 22 [Epub ahead of print]. doi: 10.1136/gutjnl-2011-300537.
- 10. Jenkins MA, Hayashi S, O’Shea AM, et al. Pathology features in Bethesda guidelines predict colorectal cancer microsatellite instability: a population-based study. Gastroenterology 2007; 133: 48-56.
- 11. Win AK, Lindor NM, Young JP, et al. Risks of primary extracolonic cancers following colorectal cancer in Lynch syndrome. J Natl Cancer Inst 2012; 104: 1363-1372.
- 12. Ait Ouakrim D, Boussioutas a, Lockett T, et al. Screening practices of unaffected people at familial risk of colorectal cancer. Cancer Prev Res (Phila) 2012; 5: 240-247.
- 13. Keogh LA, van Vliet CM, Studdert DM, et al. Is uptake of genetic testing for colorectal cancer influenced by knowledge of insurance implications? Med J Aust 2009; 191: 255-258.
We thank the study coordinators, interviewers and data managers, the many clinicians and scientists, the national and international collaborators, and especially the participants for making the ACCFR and the CCFR a success. Special thanks and honour to the late Professor Jeremy Jass, visionary pathologist and original principal investigator (PI) of the ACCFR, and to Mark Jenkins and John Hopper who have also been PIs of the ACCFR.
No relevant disclosures.