Brian McGuirk was born in Newcastle on 4 September 1939. He graduated in medicine from the University of Sydney in 1965. After a period in the United Kingdom at Guy’s Hospital, London, he returned to Australia in 1969 and took up general practice in Sydney.
In 1977, Brian was awarded a special service medal for being the first medical officer to attend victims of the Granville train disaster.

In November 2009, Brian retired at the age of 70. On 3 March 2011, he passed away quietly. His legacy was to show that an insurance doctor could successfully treat patients, rather than contest workers compensation claims.