To the Editor: Nordin and colleagues raised important issues about prescribing for osteoporosis.1 We agree that the Pharmaceutical Benefits Schedule guidelines for therapy are imperfect, but they do not necessarily lead, as Nordin et al claim, to inappropriate prescribing. For historical reasons, osteoporosis is held to be synonymous with vertebral fractures, but this misrepresents the epidemiology of fractures. Non-vertebral fractures account for 80% of all fractures and 90% of the loss of quality of life and economic costs. Vertebral fractures contribute only 20% of the burden.2 Most fractures arise in the large population at moderate risk with osteopenia — the “bell” of the Gaussian bone mineral density (BMD) distribution, not its “tail”, which comprises those with osteoporosis (defined by a bone densitometry T-score less than – 2.5). Concentrating on vertebral fractures and screening for osteoporosis with bone densitometry, as recommended by Nordin et al, is no solution to this public health problem.
The full article is accessible to AMA members and paid subscribers. Login to read more or purchase a subscription now.
Please note: institutional and Research4Life access to the MJA is now provided through Wiley Online Library.
- 1. Nordin BEC, Horowitz M, Chatterton BE. Inappropriate prescribing for osteoporosis [letter]. Med J Aust 2009; 190: 519-520. <MJA full text>
- 2. Johnell O, Kanis JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 2006; 17: 1726-1733.
- 3. Royal Australian College of General Practitioners. Osteoporosis clinical guideline April 2008 draft. http://www.racgp.org.au/Content/NavigationMenu/ClinicalResources/RACGPGuidelines/Arthritis/OPguideline.pdf (accessed Aug 2009).
- 4. Rose G. Sick individuals and sick populations. Int J Epidemiol 1985; 14: 32-38.
- 5. MacLean C, Newberry S, Maglione M, et al. Systematic review: comparative effectiveness of treatments to prevent fractures in men and women with low bone density or osteoporosis. Ann Intern Med 2008; 148: 197-213.
- 6. Seeman E, Devogelaer JP, Lorenc R, et al. Strontium ranelate reduces the risk of vertebral fractures in patients with osteopenia. J Bone Miner Res 2008; 23: 433-438.
- 7. Eisman J, Clapham S, Kehoe L. Osteoporosis prevalence and levels of treatment in primary care: the Australian BoneCare Study. J Bone Miner Res 2004; 19: 1969-1975.
- 8. Chen JS, Hogan JC, Lyubomirsky G, Sambrook PN. Management of osteoporosis in primary care in Australia. Osteoporos Int 2009; 20: 491-496.
Ego Seeman serves on the medical advisory committees of and has received speaker fees from Amgen, Eli Lilly, Merck Sharp and Dohme, Novartis, Procter and Gamble, Sanofi-Aventis and Servier. Mark Kotowicz serves on the Novartis Alcast medical advisory board and has received speaker fees and travel assistance from Merck Sharp and Dohme, Sanofi-Aventis and Servier. Peter Nash received research funding for clinical trials, and honoraria for advice from Eli Lilly, Merck Sharp and Dohme, Novartis, Sanofi and Servier, and has also lectured on their behalf. Philip Sambrook serves on the medical advisory boards of and has received speaker fees from Amgen, Merck Sharp and Dohme, Novartis, Sanofi-Aventis and Servier.