High-density lipoproteins: the next frontier in lipid management

Combined with appropriate lifestyle modification and statin therapy, raising HDL levels may be an important strategy to reduce cardiovascular risk

In the past two decades, we have made significant advances in the management of cardiovascular disease (CVD), with a dramatic reduction in cardiovascular events occurring in parallel with the widespread use of statins to lower low-density lipoprotein (LDL) cholesterol levels. Nevertheless, despite intensive use of statin therapy, a significant patient cohort remains at high risk of cardiovascular events, paving the way for new strategies to reduce their residual cardiovascular risk.