To the Editor: O’Leary and colleagues1 rightly point to the need for better evidence on whether low to moderate maternal alcohol intake affects the fetus. Evidence to date is weak and inconsistent, largely because alcohol consumption in pregnancy is generally poorly documented,2 and few studies have recorded data on factors that could potentially modify fetal exposure. Evidence could come from large pregnancy cohort studies, usually designed to address other issues, but there are no published guidelines on how to collect information relevant to fetal alcohol exposure during gestation. There is, therefore, a great need to define a core dataset for research studies, as well as one that is sufficiently simple to use in routine pregnancy care settings.
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- Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, VIC.
- 1. O'Leary CM, Heuzenroeder L, Elliott EJ, Bower C. A review of policies on alcohol use during pregnancy in Australia and other English-speaking countries, 2006. Med J Aust 2007; 186: 466-471. <MJA full text>
- 2. Henderson J, Gray R, Brocklehurst P. Systematic review of effects of low-moderate prenatal alcohol exposure on pregnancy outcome. BJOG 2007; 114: 243-252.
- 3. Savage C, Wray J, Ritchey PN, et al. Current screening instruments related to alcohol consumption in pregnancy and a proposed alternative method. J Obstet Gynecol Neonatal Nurs 2003; 32: 437-446.
- 4. Kalant H. Effects of food and body composition on blood alcohol curves. Alcohol Clin Exp Res 2000; 24: 413-414.
- 5. Warren KR, Li TK. Genetic polymorphisms: impact on the risk of fetal alcohol spectrum disorders. Birth Defects Res A Clin Mol Teratol 2005; 73: 195-203.
- 6. Wentzel P, Rydberg U, Eriksson UJ. Antioxidative treatment diminishes ethanol-induced congenital malformations in the rat. Alcohol Clin Exp Res 2006; 30: 1752-1760.