Beyond the evidence:  is there a place for antidepressant combinations  in the pharmacotherapy of depression?

Walters, Murray J; Unwin, Alston M; Gills, Sean B

doi:10.5694/j.1326-5377.2007.tb01193.x

Topics

To the Editor: Keks et al make a number of important points about the place of combination antidepressant strategies in the pharmacotherapy of depression.1 However, it is important for readers to note that the vigorous repudiation of combination treatments is a peculiarly Australian preoccupation. Our colleagues in Europe and North America are not nearly so troubled.

1 The Pinel Clinic, Brisbane, QLD.
2 The Connelly Clinic, Brisbane, QLD.

Correspondence: murray.walter@healthecare.com.au

1. Keks NA, Burrows GB, Copolov DL, et al. Beyond the evidence: is there a place for antidepressant combinations in the pharmacotherapy of depression? Med J Aust 2007; 186: 142-144. <MJA full text>
2. Horgan D, Dodd S, Berk M. A survey of combination antidepressant use in Australia. Australas Psychiatry 2007; 15: 26-29.
3. Lam R, Wan D, Cohen N, Kennedy S. Combining antidepressants for treatment resistant depression: a review. J Clin Psychiatry 2002; 63: 826-837.
4. Parker G. Evaluating treatments for the mood disorders: time for the evidence to get real. Aust N Z J Psychiatry 2004; 38: 408-414.

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