We treat patients, not levels
The goal of therapy with antiepileptic drugs (AEDs) is to prevent all seizures, using drugs that produce minimal side effects. Success in achieving this goal must be assessed clinically. Routine ordering of tests to measure AED levels is misguided, given that the tests are costly and often unnecessary.1
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- 1. Eadie MJ. The use of antiepileptic drugs in clinical practice. In: Eadie MJ, Vajda FJE, editors. Antiepileptic drugs: pharmacology and therapeutics. Heidelberg: Springer, 1999: 593-614.
- 2. Perucca E. The clinical pharmacology of the new antiepileptic drugs. Epilepsia 1999; 40 Suppl 9: S7-S13.
- 3. Rathmalgoda C, Potter JM, Lueck CJ. Serum sodium valproate testing: is it appropriate? Med J Aust 2007; 187: 582-584.
- 4. Vajda FJE, Proudfoot AD, Phillips J, Rozitis J. Use of an anticonvulsant drug plasma level monitoring service. Aust J Hosp Pharm 1981; 11: 103-107.
- 5. Wilson EA, Brodie MJ. Modern management of epilepsy. In: Brodie MJ, Treiman MD, editors. London: Baillière Tindall, 1996: 723-747.
- 6. McLaughlin D. Epilepsy. Key management issues. Aust Fam Physician 1999; 28: 889-896.
- 7. Glauser TA, Pippenger CE. Controversies in blood level monitoring: re-examining its role in the treatment of epilepsy. Epilepsia 2000; 41 Suppl 8: S6-S15.
- 8. Vajda FJE, Lander CM, Hitchcock A, et al. The case for lamotrigine monitoring in pregnancy. J Clin Neurosci 2006; 13: 103-104.
- 9. International League Against Epilepsy. Guidelines for therapeutic monitoring of antiepileptic drugs. Epilepsia 1993; 34: 585-587.
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I am the Director of the Australian Pregnancy Register of Antiepileptic Drugs, a research initiative supported by the Epilepsy Society of Australia, a National Health and Medical Research Council linkage grant, and all the pharmaceutical companies involved in the anticonvulsant field. These companies include GlaxoSmithKline, Janssen-Cilag, Mayne, Novartis, Pfizer, Sanofi and UCB. I have received honoraria for speaking at or attending international meetings to present data relating to the Register and for attending educational meetings in Australia.