Conventional treatment of saphenous vein reflux by surgical ligation or stripping leads to appreciable trauma, disruption of activities, scarring and high late recurrence rates.1 Alternative, non-surgical techniques are gaining increasing acceptance. Endovenous laser therapy (EVLT) provides a percutaneous technique to destroy larger diameter saphenous veins as an outpatient procedure under local anaesthesia, with minimal disruption of activities and no surgical trauma.2-5 In this article, we describe our early results for 404 saphenous veins in 308 patients treated by EVLT and followed up by ultrasound surveillance.
The clinical, aetiological, anatomical, and pathophysiological (CEAP) classification was used to assess the limbs.6 There were 361 limbs with uncomplicated varicose veins (C2–3, 91%) and 35 limbs with complications (C4–6), due to lipodermatosclerosis (n = 26), healed past venous ulceration (n = 6) or active ulceration (n = 3). Primary disease was present in all limbs, and none had features of the post-thrombotic syndrome. There was persistent or recurrent reflux after past saphenous vein surgery by other surgeons in 20 limbs (15 for great saphenous and 5 for small saphenous disease).
Duplex scanning performed by specialist vascular sonographers linked to the surgical units was used to select saphenous veins suitable for EVLT. Limbs were evaluated to detect superficial, deep and perforator reflux, mark the site and extent of disease, and measure the length and diameters of refluxing saphenous veins as previously described.7 All limbs treated had reflux through the corresponding saphenous junction or other major connections to deep veins. The lengths of veins treated ranged from 5 to 55 cm (median, 34 cm) and their diameters from 5 to 20 mm (median, 8 mm).
Follow-up with serial ultrasound scans at the above intervals was used for survival analysis.8 Success was defined as continuing occlusion or obliteration without reflux in any segment of treated vein, as determined by ultrasound.
Univariate Kaplan–Meier life table analysis was used to calculate primary and secondary ultrasound success and failure rates.8 The time to failure was the difference between the date of EVLT and the date that recurrent reflux was demonstrated at follow-up scans. All patients presented for the first post-procedure scan at day 3–7; if failure was noted at this scan, then this was used as the failure date for survival analysis, although it is probable that the procedure had failed from the time it was performed. If a patient noted to have recurrent saphenous reflux had missed a previous scheduled visit, then failure due to recurrent saphenous reflux was dated back to the time of that missed visit.
In 21 limbs, recanalisation was detected on surveillance, usually to a minor degree when compared with the initial reflux. This resulted in a primary ultrasound success rate at 3 years by life table analysis of 80% (95% CI, 69%–87%) (Box 1A). Eleven of these limbs were treated by ultrasound-guided sclerotherapy to obliterate the recurrent vein at intervals from 7 to 570 days after EVLT, and this was successful in all but one, resulting in a secondary ultrasound success rate at 3 years by life table analysis of 88% (95%,CI, 78%–95%) (Box 1B).
Thromboembolic complications can occur with any treatment for varicose veins. In this series, EVLT had a 2.2% incidence of thromboembolic complications. Van Rij and colleagues documented deep vein thrombosis in 5.3% of limbs after varicose vein surgery, although most were localised to the tibial veins.9
EVLT damages a blood-filled vessel by steam formation, leading to endothelial denudation, collagen contraction and vein wall fibrosis,10-13 and in many limbs the vein is no longer visible at the 6–12 month scans. Our results are similar to those in another large series.2 Other studies have reported satisfactory results for the great saphenous3,4 and small saphenous veins.5
An alternative technique using thermal ablation from a radiofrequency probe has also produced good results with low complication rates.14-17 Ultrasound surveillance shows occlusion of most saphenous veins and infrequent development of new veins in the groin with this technique.16 Randomised trials of radiofrequency closure versus surgery found significantly less postoperative pain, faster rehabilitation, lower cost and persisting better quality of life, as well as similar control of the veins.14-17
Outcomes are satisfactory for treatment of saphenous reflux by ultrasound-guided sclerotherapy,18-20 but there is insufficient information to determine the efficacy of ultrasound-guided sclerotherapy for larger saphenous veins.
Ultrasound surveillance detects a high incidence of failure after surgery for varicose veins.1 Van Rij and colleagues found 25% recurrence after great saphenous surgery and 50% recurrence after small saphenous surgery at 3 years.21 A Swedish study of outcome 10 years after great saphenous ligation and stripping found that 86 of 100 limbs had recurrence involving segments of the great saphenous veins.22 Ultrasound studies after small saphenous surgery found that only 39% of 59 operations were successful at early follow-up in a British report,23 and 5 of 28 operations were successful at 3 months in a Dutch study.24 A British review suggests that this may be due to reluctance to strip the small saphenous vein because of fear of nerve injury.25
There is a high incidence of reconnection from the common femoral vein or low abdominal or pelvic veins to thigh tributaries after surgery, due to opening of pre-existing veins.26,27 Traditional teaching is to ligate all tributaries at the saphenofemoral junction, but there is growing concern that this might predispose to reconnections into thigh veins rather than normal drainage through the saphenous junction. Endovenous techniques are not associated with a high incidence of recurrence in the groin,28 suggesting that leaving tributaries from above the groin may be an advantage.
Received 18 April 2005, accepted 20 May 2006
- Kenneth Myers1
- Robert Fris2
- Damien Jolley3
- 1 Epworth Hospital, Melbourne, VIC.
- 2 Northern Vein Centre, Auckland, New Zealand.
- 3 Monash Institute of Health Services Research, Melbourne, VIC.
We thank our sonographers and nursing sister — Amy Clough, Jacqui Kirwan, Michelle Rodeh, Jane Chambers and Penny Koh in Melbourne, and Bronwyn Allen and Daryl Queenin in Auckland — for their invaluable assistance and advice.
None identified.
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Abstract
Objective: To assess the efficacy of endovenous laser therapy (EVLT) for treating varicose veins with saphenous reflux.
Design: A trial of treatment, with results assessed by ultrasound surveillance.
Setting: Outpatient clinics with sonographer and nursing support.
Main outcome measures: Control of reflux; occlusion or obliteration of the saphenous veins assessed by ultrasound.
Results: EVLT was used to treat 404 veins in 308 patients. Univariate life table analysis showed primary success in 80% (95% CI, 69%–87%) and secondary success after further treatment of recurrent saphenous vein reflux by ultrasound-guided sclerotherapy in 88% (95% CI, 78%–95%) at 3 years. On multivariate Cox regression analysis, none of the covariates studied were associated with ultrasound failure.
Conclusions: Early results indicate that EVLT effectively controlled saphenous reflux. Its advantages are that it is performed as an outpatient procedure under local anaesthesia with immediate mobilisation, causes minimal disruption of activities, and avoids surgical trauma.