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A possible animal model of naturally occurring multinodular goitre in the Nilgiris of southern India

Biji T Kurien and Jobin T Kurien
Med J Aust 2006; 185 (11): . || doi: 10.5694/j.1326-5377.2006.tb00760.x
Published online: 4 December 2006

Until recently, iodine deficiency had been prevalent for centuries in a number of landlocked mountainous regions of the world.1,2 The Himalayan region3 and the Bernese region of Switzerland4 were especially known for severe endemic goitre as a result of this deficiency. Since the 1920s, the prevalence of goitre has fallen with the widespread use of iodised table salt.4


  • 1 Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Okla, USA.
  • 2 Mustang High School, Mustang, OK, 73064, USA.


Correspondence: biji-kurien@omrf.ouhsc.edu

Competing interests:

None identified.

  • 1. Merke F. History and iconography of endemic goitre and cretinism. Bern: Hans Huber, 1984.
  • 2. Als C, Stüssi Y, Boschung U, et al. Visible signs of illness from the 14th to the 20th century: systematic review of portraits. BMJ 2002; 325: 21-28.
  • 3. Ibberston HK. Goitre and cretinism in the high Himalayas. N Z Med J 1974; 80: 484-488.
  • 4. Als C, Keller A, Minder C, et al. Age- and gender-dependent urinary iodine concentrations in an area-covering population sample from the Bernese region in Switzerland. Eur J Endocrinol 2000; 143: 629-637.
  • 5. Livingston RS, Franklin CL, Lattimer JC, et al. Evaluation of hyperplastic goiter in a colony of Syrian hamsters (Mesocricetus auratus). Lab Anim Sci 1997; 47: 346-350.
  • 6. Schiller CA, Montali RJ, Doi S, Grollman EF. Clinical and morphologic findings of familial goiter in bongo antelope (Tragelaphus eurycerus). Vet Pathol 1995; 32: 242-249.
  • 7. Tassi VP, Di Lauro R, Van Jaarsveld P, Alvino CG. Two abnormal thyroglobulin-like polypeptides are produced from Afrikander cattle congenital goiter mRNA. J Biol Chem 1984; 259: 10507-10510.
  • 8. Taylor BA, Rowe L. The congenital goiter mutation is linked to the thyroglobulin gene in the mouse. Proc Natl Acad Sci U S A 1987; 84: 1986-1990.
  • 9. Fyfe JC, Kampschmidt K, Dang V, et al. Congenital hypothyroidism with goiter in toy fox terriers. J Vet Intern Med 2003; 17: 50-57.
  • 10. Welchman DD, Cranwell MP, Wrathall AE, Christensen P. An inherited congenital goitre in pigs. Vet Rec 1994; 135: 589-593.
  • 11. Jones BR, Gruffydd-Jones TJ, Sparkes AH, Lucke VM. Preliminary studies on congenital hypothyroidism in a family of Abyssinian cats. Vet Rec 1992; 131: 145-148.
  • 12. Baker JR, Wyn-Jones G, Eley JL. Case of equine goitre. Vet Rec 1983; 112: 407-408.
  • 13. Pandav CS, Anand K. Towards the elimination of iodine deficiency disorders in India. Indian J Pediatr 1995; 62: 545-555.
  • 14. Co-operation, Food and Consumer Protection Department, Government of Tamil Nadu. Food and public distribution. Policy note 2003–2004, demand no. 12, chapter XI: Food and public distribution. http://www.tn.gov.in/policynotes/archives/policy2003-04/cfcp2003-04-11.htm (accessed Nov 2006).
  • 15. International Council for Control of Iodine Deficiency Disorders. IDD Newsletter 2005; 21(4). http://indorgs.virginia.edu/iccidd/newsletter/v21n4_1105.pdf (accessed Nov 2006).

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