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The anti-TNF revolution in ankylosing spondylitis

Lionel Schachna
Med J Aust 2004; 181 (10): . || doi: 10.5694/j.1326-5377.2004.tb06436.x
Published online: 15 November 2004

Patients with severe disease now have access to promising new drugs

To have lived through a revolution, to have seen a new birth of science, a new dispensation of health . . . is not given to every generation.
William Osler (1913)


  • Austin Spondylitis Centre, Austin Health, Heidelberg, VIC.


Correspondence: 

  • 1. Health Insurance Commission. Pharmaceutical Benefits Scheme. Infliximab – for active ankylosing spondylitis. Schedule restriction details. 2004. Available at: www.hic.gov.au/providers/forms/pbs/mp/infliximab_as/schedule_restriction.htm (accessed Oct 2004).
  • 2. Lehtinen K. Mortality and causes of death in 398 patients admitted to hospital with ankylosing spondylitis. Ann Rheum Dis 1993; 52: 174-176.
  • 3. Clegg DO, Reda DJ, Abdellatif M. Comparison of sulfasalazine and placebo for the treatment of axial and peripheral articular manifestations of the seronegative spondylarthropathies: a Department of Veterans Affairs cooperative study. Arthritis Rheum 1999; 42: 2325-2329.
  • 4. Braun J, Bollow M, Neure L, et al. Use of immunohistologic and in situ hybridization techniques in the examination of sacroiliac joint biopsy specimens from patients with ankylosing spondylitis. Arthritis Rheum 1995; 38: 499-505.
  • 5. van der Heijde D, Calin A, Dougados M, et al. Selection of instruments in the core set for DC-ART, SMARD, physical therapy, and clinical record keeping in ankylosing spondylitis. Progress report of the ASAS Working Group. Assessments in ankylosing spondylitis. J Rheumatol 1999; 26: 951-954.
  • 6. Anderson JJ, Baron G, van der Heijde D, et al. Ankylosing spondylitis assessment group preliminary definition of short-term improvement in ankylosing spondylitis. Arthritis Rheum 2001; 44: 1876-1886.
  • 7. Braun J, Pham T, Sieper J, et al. International ASAS consensus statement for the use of anti-tumour necrosis factor agents in patients with ankylosing spondylitis. Ann Rheum Dis 2003; 62: 817-824.
  • 8. Braun J, Brandt J, Listing J, et al. Treatment of active ankylosing spondylitis with infliximab: a randomised controlled multicentre trial. Lancet 2002; 359: 1187-1193.
  • 9. Braun J, Brandt J, Listing J, et al. Long-term efficacy and safety of infliximab in the treatment of ankylosing spondylitis: an open, observational, extension study of a three-month, randomized, placebo-controlled trial. Arthritis Rheum 2003; 48: 2224-2233.
  • 10. Davis JC Jr, van der Heijde D, Braun J, et al. Recombinant human tumor necrosis factor receptor (etanercept) for treating ankylosing spondylitis: a randomized, controlled trial. Arthritis Rheum 2003; 48: 3230-3236.
  • 11. Rudwaleit M, van der Heijde D, Khan MA, et al. How to diagnose axial spondyloarthritis early. Ann Rheum Dis 2004; 63: 535-543.

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