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Acute liver failure associated with the use of herbal preparations containing black cohosh

Michael Thomsen, Luis Vitetta, Avni Sali and Matthias Schmidt
Med J Aust 2004; 180 (11): . || doi: 10.5694/j.1326-5377.2004.tb06109.x
Published online: 7 June 2004

Michael Thomsen,* Luis Vitetta, Avni Sali, Matthias Schmidt§


  • 1 and Director of Research
  • 2 Graduate School of Integrative Medicine, Swinburne University, 9 Frederick Street, Hawthorn, VIC 3122
  • 3 Society of Nutritional Medicine and Dietetics, Harsewinkel, Germany.



Competing interests:

Michael Thomsen had paid consultancy in 2003 with Phytomedicine Pty Ltd, which has a product containing black cohosh; he has no stock, stock options or other financial interests in Phytomedicine Pty Ltd. Michael Thomsen is a director of HerbResearch Pty Ltd, which sells herbal medicines but does not currently have any products containing black cohosh.

  • 1. Lontos S, Jones RM, Angus PW, Gow PJ. Acute liver failure associated with the use of herbal preparations containing black cohosh. Med J Aust 2003; 179: 390-391. <eMJA full text>
  • 2. Vitetta L, Thomsen M, Sali A. Black cohosh and other herbal remedies associated with acute hepatitis. Med J Aust 2003; 178: 411-412. <eMJA full text>
  • 3. Whiting PW, Clouston A, Kerlin P. Black cohosh and other herbal remedies associated with acute hepatitis. Med J Aust 2002; 177: 440-443.<eMJA full text>
  • 4. Liske E. Therapeutic efficacy and safety of Cimicifuga racemosa for gynecologic disorders. Adv Ther 1998; 15: 45-53.
  • 5. Korn WD. Six-month oral toxicity study with Remifemin granulate in rats followed by an eight-week recovery period. Hanover: International Bioresearch, 1991.

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