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Pre-eclampsia: a lifelong disorder

Mark A Brown
Med J Aust 2003; 179 (4): . || doi: 10.5694/j.1326-5377.2003.tb05495.x
Published online: 18 August 2003

Some women with pre-eclampsia develop hypertension and cardiovascular disease in later life


  • Department of Renal Medicine, St George Hospital, and University of New South Wales, Sydney, NSW.


Correspondence: 

  • 1. Li DK, Wi S. Changing paternity and the risk of pre-eclampsia/eclampsia in the subsequent pregnancy. Am J Epidemiol 2000; 151: 57-62.
  • 2. Robillard PY, Hulsey TC. Association of pregnancy-induced hypertension, pre-eclampsia and eclampsia with duration of sexual cohabitation before conception. Lancet 1994; 344: 973-975.
  • 3. Maynard SE, Min J-Y, Merchan J, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 2003; 111: 649-658.
  • 4. Savvidou MD, Hingorani AD, Tsikas D, et al. Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia. Lancet 2003; 361: 1511-1517.
  • 5. Knight M, Duley L, Henderson-Smart DJ, King JF. Antiplatelet agents for preventing and treating pre-eclampsia (Cochrane Review). In: The Cochrane Library, Issue 1, 2003. Oxford: Update Software.
  • 6. The Magpie Trial Collaborative Group. Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial. Lancet 2002; 359: 1877-1890.
  • 7. Brennecke SP, Brown MA, Crowther CA, et al. Aspirin and prevention of preeclampsia. Position statement of the use of low-dose aspirin in pregnancy by the Australasian Society for the Study of Hypertension in Pregnancy. Aust N Z J Obstet Gynaecol 1995; 35: 38-41.
  • 8. Irgens HU, Reisaeter L, Irgens LM, Lie RT. Long term mortality of mothers and fathers after pre-eclampsia: population based cohort study. BMJ 2001; 323: 1213-1217.
  • 9. Wilson BJ, Watson MS, Prescott GJ, et al. Hypertensive diseases of pregnancy and risk of hypertension and stroke in later life: results from cohort study. BMJ 2003; 326: 845-851.

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