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Does a combined program of dietary modification and physical activity or the use of metformin reduce the conversion from impaired glucose tolerance to type 2 diabetes?

Dorothy EM Mackerras
Med J Aust 2003; 178 (4): . || doi: 10.5694/j.1326-5377.2003.tb05138.x
Published online: 17 February 2003

Trial: Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346: 393-403.


  • Menzies School of Health Research, Casuarina, NT.


Correspondence: 

Competing interests:

None identified.

  • 1. Diabetes Prevention Program Research Group. The Diabetes Prevention Program. Design and methods of a clinical trial in the prevention of type 2 diabetes. Diabetes Care 1999; 22: 623-634.
  • 2. Diabetes Prevention Program. Study documents website: http://www.bsc.gwu.edu/dpp/index.htmlvdoc (accessed Dec 2002).
  • 3. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997; 20: 1183-1197.
  • 4. Dunstan DW, Zimmet PZ, Welborn TA, et al. The rising prevalence of diabetes and impaired glucose tolerance: the Australian Diabetes, Obesity and Lifestyle Study. Diabetes Care 2002; 25: 829-834.
  • 5. Tuomilehto J, Lindstrom J, Eriksson JG, et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001; 344: 1343-1350.
  • 6. Newell D, Simpson J. Regression to the mean. Med J Aust 1990; 153: 166-168.
  • 7. de Courten M, Hodge A, Dowse G, et al. Review of the epidemiology, aetiology pathogenesis and preventability of diabetes in Aboriginal and Torres Strait Islander populations. Canberra: OATSIH, Commonwealth Department of Health and Family Services, 1998.

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