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Can we really beat cervical cancer?

Suzanne M Garland
Med J Aust 2003; 178 (12): . || doi: 10.5694/j.1326-5377.2003.tb05396.x
Published online: 16 June 2003

Vaccination has the potential to reduce the global burden of disease from genital HPV infection


  • Department of Microbiology and Infectious Diseases, Royal Women's Hospital, Carlton, VIC.


Correspondence: 

  • 1. Ferlay J, Bray F, Pisani P, Parkin DM. GLOBOCAN 2000: cancer incidence, mortality and prevalence worldwide, version 1.0. IARC CancerBase No. 5. Lyon: IARC Press, 2001. Available (in part) at: http://www-dep.iarc.fr/globocan/globocan.html (accessed May 2003).
  • 2. International Agency for Research on Cancer. Monographs on the evaluation of the carcinogenic risks to humans. Vol 64. Human papillomaviruses. Lyon: IARC, 1995.
  • 3. Walboomers JM, Jacobs MV, Manos MM, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 1999; 189: 12-19.
  • 4. Muñoz N, Bosch FX, de Sanjosé S, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 2003; 348: 518-527.
  • 5. Bosch FX, Lorincz A, Muñoz N, et al. The causal relation between human papillomavirus and cervical cancer [review]. J Clin Pathol 2002; 55: 244-265.
  • 6. Kjaer SK, van den Brule AJ, Paull G, et al. Type specific persistence of high-risk human papillomavirus as indicator of high-grade cervical squamous intraepithelial lesions in young women: population based prospective follow up study. BMJ 2002; 325: 572-576.
  • 7. Sherman ME, Lorincz AT, Scott DR, et al. Baseline cytology, human papillomavirus testing, and risk for cervical neoplasia: a 10-year cohort analysis. J Natl Cancer Inst 2003; 95: 46-52.
  • 8. Digene Corporation press release. Digene high-risk HPV DNA test approved by the FDA for adjunctive screening in women age 30 and older. Gaithersburg, Md, USA, 1 April 2003. Available at: http: //www.digene.com/corporate01/press_releases/prelease_frame.html (accessed May 2003).
  • 9. Koutsky LA, Ault KA, Wheeler CM, et al. A controlled trial of a human papillomavirus type 16 vaccine. N Engl J Med 2002; 347: 1645-1651.
  • 10. Zhou J, Sun XY, Stenzel DJ, Frazer IH. Expression of vaccinia recombinant HPV 16 L1 and L2 ORF proteins in epithelial cells is sufficient for assembly of HPV virion-like particles. Virology 1991; 185: 251-257.
  • 11. Bill and Melinda Gates Foundation press release. Alliance for Cervical Cancer Prevention receives $50 million gift from Bill and Melinda Gates. Seattle, Wash, USA, 22 Sept 1999. Available at: http://www.gatesfoundation.org/GlobalHealth/ReproductiveChildHealth/Announcements/Announce-98.htm (accessed May 2003).
  • 12. Steller MA. Update on human papillomavirus vaccines for cervical cancer. Curr Opin Investig Drugs 2002; 3: 37-47.

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