Does preoperative radiotherapy improve outcome in patients with resectable rectal cancer?

• Department of Radiation Oncology, Westmead Hospital, Westmead, NSW.

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• 1. Phillips RK, Hittinger R, Blesovsky L, et al. Local recurrence following 'curative' surgery for large bowel cancer. The overall picture. Br J Surg 1984; 71: 12-16.
• 2. Ooi BS, Tjandra JJ, Green MD. Morbidities of adjuvant chemotherapy and radiotherapy for resectable rectal cancer. Dis Colon Rectum 1999; 42: 403-441.
• 3. Stevens G, Firth I, Solomon M, et al. Rectal cancer: changing patterns of referral for radiation therapy 1982–1997. Aust N Z J Surg 2000; 70: 553-559.
• 4. Kockering F, Reymond MA, Altendorf-Hofmann A, et al. Influence of surgery on metachronous distant metastases and survival in rectal cancer. J Clin Oncol 1998; 16: 324-329.
• 5. Kapiteijn E, Marijnen CAM, Nagtegaal ID, et al, for the Dutch Colorectal Cancer Group. Acute side effects and complications after short term preoperative radiotherapy combined with total mesorectal excision in primary rectal cancer: Report of a multicenter randomized trial. J Clin Oncol 2002; 20: 817-825.
• 6. Swedish Rectal Cancer Trial. Improved survival with preoperative radiotherapy in resectable rectal cancer. N Engl J Med 1997; 336: 980- 987.
• 7. Sobin LH, Wittekind C, editors. TMN classification of malignant tumours. UICC International Union Against Cancer. New York: Wiley-Liss, 1997: 67-68.
• 8. National Health and Medical Research Council. Guidelines for the prevention, early detection and management of colorectal cancer. Canberra: NHMRC 1999.
• 9. Krook JE, Moertel CG, Gunderson LL, et al. Effective surgical adjuvant therapy for high risk rectal cancer. N Engl J Med 1991; 324: 709-715.