Safety of hormone replacement therapy after mastectomy

Del Mar, Christopher B; Glasziou, Paul P; Spinks, Anneliese B; Sanders, Sharon L; Hilton, Deborah J

doi:10.5694/j.1326-5377.2002.tb04411.x

Topics

After mastectomy, chemotherapy and radiotherapy for high-grade ductal carcinoma with nodal involvement and lymphatic infiltration, a 48-year-old woman had premature menopause, with symptoms of loss of libido. Her general practitioner wanted to know how safe and effective hormone replacement therapy (HRT) would be for this patient.

Centre for General Practice, Medical School, University of Queensland, Herston, QLD.

Correspondence: c.delmar@cgp.uq.edu.au

1. Guidozzi F. Estrogen replacement therapy in breast cancer survivors. Int J Gynaecol Obstet 1999; 64: 59-63.
2. Wile AG, Opfell RW, Margileth DA. Hormone replacement therapy in previously treated breast cancer patients. Am J Surg 1993; 165: 372-375.
3. DiSaia PJ, Grosen EA, Odicino F, et al. Replacement therapy for breast cancer survivors. A pilot study. Cancer 1995; 76: 2075-2078.
4. DiSaia PJ, Grosen EA, Kurosaki T, et al. Hormone replacement therapy in breast cancer survivors: a cohort study. Am J Obstet Gynecol 1996; 164: 1494-1498.
5. Ursic-Vrscaj M, Bebar S. A case-control study of hormone replacement therapy after primary surgical breast cancer treatment. Eur J Surg Oncol 1999; 25: 146-151.

Online responses are no longer available. Please refer to our instructions for authors page for more information.