Thrombophilia screening and adverse pregnancy outcomes associated with uteroplacental insufficiency

Morgans, David

doi:10.5694/j.1326-5377.2002.tb04597.x

Topics

To the Editor: The recent article by the Obstetric Medicine Group of Australasia alluded to the increasing relevance and importance of thrombophilia screening following adverse pregnancy outcomes, namely recurrent miscarriage, stillbirth, retarded intrauterine growth and pre-eclampsia.1 Formerly, these outcomes were generally attributed to "placental insufficiency", where a cause was not readily identified.

Correspondence:

1. Hague WM, North RA, Gallus AS, et al. Anticoagulation in pregnancy and the puerperium. Med J Aust 2001; 175: 258-263.
2. Brenner B. Inherited thrombophilia and pregnancy loss. Thromb Haemost 1999; 82: 634-640.
3. Brenner B, Hoffman R, Blumenfeld Z, et al. Gestational outcome in thrombophilic women with recurrent pregnancy loss treated by Enoxaparin. Thromb Haemost 2000; 83: 693-697.
4. Preston FE, Rosendaal FR, Walker ID, et al. Increased fetal loss in women with heritable thrombophilia. Lancet 1996; 348: 913-916.
5. Rai R, Regun L, Hadley E, et al. Second trimester pregnancy loss is associated with activated protein C resistance. Br J Haematol 1996; 92: 489-490.

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