An Australian study, published in 1998, described histological features of breast cancers occurring in young women with germline mutations in two specific genes.1 In 2000, a multicentre US group conducting molecular analysis of a series of diffuse large B-cell lymphomas reported that, within this group of morphologically indistinguishable tumours, two distinct types of lymphoma could be identified by gene-expression profiles, and that these two types had significantly different prognoses.2
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