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Saving money on the PBS: ranibizumab or bevacizumab for neovascular macular degeneration?

Ken J Harvey, Richard O Day, William G Campbell and Wendy Lipworth
Med J Aust 2011; 194 (11): . || doi: 10.5694/j.1326-5377.2011.tb03105.x
Published online: 6 June 2011

The cost differential between these two drugs is no longer defensible

Federal Health Minister Nicola Roxon recently met with an alliance of consumer, industry and other stakeholders to justify the government’s plan to indefinitely delay the listing of seven new medicines on the Pharmaceutical Benefits Scheme (PBS). She argued that, after considering the advice of the Pharmaceutical Benefits Advisory Committee (PBAC), it was the government’s responsibility to decide whether or not to list a new drug, taking into account other priorities across the health portfolio and current fiscal circumstances.1


  • 1 School of Public Health, La Trobe University, Melbourne, VIC.
  • 2 St Vincent’s Hospital and University of New South Wales, Sydney, NSW.
  • 3 Royal Victorian Eye and Ear Hospital, Melbourne, VIC.
  • 4 Australian Institute of Health Innovation, University of New South Wales, Sydney, NSW.


Correspondence: ken.harvey@latrobe.edu.au

Competing interests:

Ken Harvey represented the Chronic Illness Alliance at the Consumers Health Forum PBS Summit. Richard Day is a member of the Ad Hoc Advisory Committee on Drugs in Development for Novartis Australia.

  • 1. Roxon N. Opening address to Consumers Health Forum PBS Summit, 29 Apr 2011. http://www.hirc.health.gov.au/internet/ministers/publishing.nsf/Content/F2D512F124949662CA257881001FC9AD/$File/nrsp290411.pdf (accessed May 2011).
  • 2. Taylor HR, Keeffe JE, Vu HT, et al. Vision loss in Australia. Med J Aust 2005; 182: 565-568. <MJA full text>
  • 3. Rosenfeld PJ, Brown DM, Heier JS, et al. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 2006; 355: 1419-1431.
  • 4. Brown DM, Kaiser PK, Michels M, et al. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med 2006; 355: 1432-1444.
  • 5. Fong DS, Custis P, Howes J, et al. Intravitreal bevacizumab and ranibizumab for age-related macular degeneration: a multicenter, retrospective study. Ophthalmology 2010; 117: 298-302.
  • 6. Rosenfeld PJ, Moshfeghi AA, Puliafito CA. Optical coherence tomography findings after an intravitreal injection of bevacizumab (Avastin) for neovascular age-related macular degeneration. Ophthalmic Surg Lasers Imaging 2005; 36: 331-335.
  • 7. Avery RL, Pieramici DJ, Rabena MD, et al. Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration. Ophthalmology 2006; 113: 363-372.
  • 8. Australian Government Department of Health and Ageing. National Medicines Policy. 2000. Canberra: Commonwealth of Australia, 1999.
  • 9. Australian Government. National Strategy for Quality Use of Medicines. Canberra: Commonwealth of Australia, 2002.
  • 10. The CATT Research Group. Ranibizumab and bevacizumab for neovascular age-related macular degeneration. N Engl J Med 2011; 364: 1966-1967.
  • 11. Australian Government Department of Health and Ageing, Therapeutic Goods Administration. Australian regulatory guidelines for prescription medicines. Canberra: Commonwealth of Australia, 2004. http://www.tga.gov.au/pdf/pm-argpm.pdf (accessed May 2011).

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