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Notable Cases

Early detection of malignant pleural mesothelioma through measurement of soluble mesothelin-related protein and positron emission tomography

Emma L O’Lone, Eun-Kee Park, Alessandra Sandrini, Gerald B Fogarty and Deborah H Yates
MJA 2009; 190 (3): 158-159

A 51-year-old man with no known history of asbestos exposure presented with hydropneumothorax. Soluble mesothelin-related protein testing and combined positron emission tomography and computed tomography were used to diagnose malignant pleural mesothelioma. One year after radical surgery and radiotherapy, there was no clinical recurrence.

Clinical record

A 51-year-old man who was born in South Africa presented with shortness of breath on exertion, increasing lethargy and a dry cough. He had never smoked. Medical history included nephritis at the age of 6 years, sinus drainage 20 years earlier, and psoriasis. He had no history of occupational or non-occupational exposure to asbestos, and had not lived near asbestos mines while in South Africa. He had not performed home renovations or building work in South Africa or Australia. After 12 months of national service in the South African Army, he worked in a plastics business in South Africa, selling perspex and acrylic products; he reported no involvement in plastics manufacturing. Since moving to Australia in 1995, he had worked in sales.

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©The Medical Journal of Australia 2009 www.mja.com.au PRINT ISSN: 0025-729X ONLINE ISSN: 1326-5377