Case scenario*

A 60-year-old farmer was stung on the neck while driving a truck. After parking, he removed a stinger and found a dying bee. Within 5 minutes he experienced flushing, sweating, fading vision and momentary loss of consciousness. He was too confused to call an ambulance on his mobile phone, but managed to stumble out of the vehicle and lie on the ground, where he was found by a passing motorist 10 minutes later. An ambulance was called.

Paramedics arrived 20 minutes after the sting event and noted the man was wearing a MedicAlert bracelet. He was arousable, showed no respiratory distress or rash, and had a regular pulse rate of 55 beats/min and systolic blood pressure of 80 mmHg. The patient had brief expiratory wheeze and a blood oxygen saturation level of 88%. His condition improved with horizontal posture and with administration of oxygen, intramuscular adrenaline (0.5 mg injected into the lateral thigh) and nebulised salbutamol. On arrival at a hospital emergency department 30 minutes later, he received another intramuscular injection of adrenaline (0.3 mg), and 2 L normal saline was given intravenously over 20 minutes. A transient urticaria was noted.

After another 4 hours’ observation, the patient was discharged with a prescription for an automated adrenaline syringe (EpiPen), an emergency anaphylaxis action plan, and an appointment arranged to visit an allergy clinic.

The man had tolerated bee stings on multiple occasions up to the age of 53 years, when, for the first time, he developed flushing and mild wheezing 15 minutes after a sting. At that time, he was provided with an EpiPen. Five years later, he experienced an uneventful bee sting and decided not to renew the EpiPen. Intercurrent problems included mild chronic airflow obstruction, a history of smoking (until 30 years of age) and borderline hypertension (treated with a thiazide).

Specialist allergy assessment 1 month after discharge demonstrated serum-specific IgE to honeybee venom at 10 kU/L and a positive skin test to the venom at 0.01 μg/mL (intradermal). Based on sighting the insect, the presence of a stinger and demonstration of high-level specific IgE to honeybee venom, the recent events were attributed to allergy to honeybee sting. The patient’s respiratory and cardiac comorbidities may also have contributed to the severity of the reaction (Level IV).

Because of his occupation, the presence of comorbidities, the severe, hypotensive anaphylaxis after the latest sting, and the slow trend to higher failure rates once venom immunotherapy is discontinued,2 the patient was trained in using an EpiPen device and advised to carry one at all times and to undergo honeybee venom immunotherapy indefinitely. He was also given contact numbers for emergency services (dial 000 in Australia, or 112 from a mobile phone anywhere in the world) and advised how to minimise exposure.

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* This is a fictional case scenario based on similar real-life cases.