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Is bupropion (Zyban) causing deaths?

Simon C Chapman and Konrad Jamrozik
Med J Aust 2002; 176 (3) || doi: 10.5694/j.1326-5377.2002.tb04323.x
Published online: 21 January 2002

To the Editor: From 1 February to 30 June 2001, 277 602 prescriptions for the smoking cessation drug bupropion hydrochloride (Zyban, GlaxoSmithKline) were processed. The Health Insurance Commission approved 343 737 prescriptions for bupropion between 1 February and 30 June.1 Comparing this figure with the 277 602 processed scripts, some 66 135 (19.2%) scripts went unfilled. One reason for this may have been extensive publicity given to reports of deaths and numerous adverse reactions following bupropion use.

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Correspondence: simonc@health.usyd.edu.au

Competing interests:

SC has received funding from SmithKlineBeecham (now GlaxoSmithKline) for the preparation of professional and public educational material on smoking in Australia.

  • 1. Health Insurance Commission. Prescription data, item 8465M. 2001. <http://www.hic.gov.au/statistics/dyn_pbs/forms/pbs_tab1.shtml#info>. Accessed 22 Jun 2005.
  • 2. ADRAC update on buproprion (Zyban). Therapeutic Goods Administration website. <http://www.tga.gov.au/docs/html/zyban.htm>. Accessed 22 Jun 2005.
  • 3. Wald NJ, Hackshaw AK. Cigarette smoking: an epidemiological overview. Br Med Bull 1996; 52: 3-11.
  • 4. Breslau N, Peterson EL, Schultz LR, et al. Major depression and stages of smoking. A longitudinal investigation. Arch Gen Psychiatry 1998; 55: 161-166.
  • 5. Miller M, Hemenway D, Bell NS, et al Cigarette smoking and suicide: a prospective study of 300,000 male active-duty Army soldiers. Am J Epidemiol 2000; 151: 1060-1063.
  • 6. Beaglehole R, Stewart A, Jackson R, et al. Declining rates of coronary heart disease in New Zealand and Australia, 1983-1993. Am J Epidemiol 1997; 145: 707-713.

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